J. Trujillo

发表

Facile esterification of sulfonic acids and carboxylic acids with triethylorthoacetate

A. Gopalan, J. I. Trujillo, J. Trujillo, 1993 .

Design, synthesis and biological evaluation of carbohydrate-based mimetics of cRGDFV

K. Chibale, K. Nicolaou, J. I. Trujillo, 1997 .

Design, synthesis and biological evaluation of nonpeptide integrin antagonists.

K. Chibale, K. Nicolaou, S. Goodman, 1998, Bioorganic & medicinal chemistry.

Novel tetrahydro-beta-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2).

David R. Anderson, D. Reitz, M. J. Meyers, 2007, Bioorganic & medicinal chemistry letters.

Effect of the acidic component on the Mitsunobu inversion of a sterically hindered alcohol

J. Dodge, J. I. Trujillo, Misti Presnell, 1994 .

PF-06651600, a Dual JAK3/TEC Family Kinase Inhibitor.

R. Everley, J. Telliez, Liang Xue, 2019, ACS chemical biology.

Macrocyclic Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonists.

F. Vajdos, M. Schnute, M. Vazquez, 2023, ACS medicinal chemistry letters.

Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist.

David C. Wood, K. Fennell, R. Kurumbail, 2018, Journal of medicinal chemistry.

Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): a tale of two waters.

Wei Huang, Atli Thorarensen, James R Kiefer, 2012, Bioorganic & medicinal chemistry letters.

Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors.

J. Bauman, J. Telliez, J. Chrencik, 2018, Journal of medicinal chemistry.

Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841).

Li Xing, Eddine Saiah, David Lin, 2018, Journal of medicinal chemistry.

Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans.

M. Hegen, J. Telliez, J. Chrencik, 2017, Journal of medicinal chemistry.

Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition.

J. Bauman, J. D. Clark, M. Hegen, 2016, ACS chemical biology.

Cine-Substitutions of Five-Membered Hetarenes via Sulfonium Salts

V. Snieckus, J. Trujillo, 2020 .

Aminopyrazole Carboxamide Bruton's Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning.

Daniel P. Walker, Dean M. Messing, A. Wittwer, 2018, ACS medicinal chemistry letters.

Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1.

J. D. Clark, M. Hegen, Betsy S. Pierce, 2020, Bioorganic & medicinal chemistry.

Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS).

D. Rohrer, C. Carron, C. Wegner, 2010, ACS medicinal chemistry letters.

Efforts towards Rh(II)-catalyzed N-alkoxyazomethine ylide generation: Disparate reactivities of O-tethered α-diazo keto and -β-ketoester oximes

S. Wright, Andrew C Flick, Doris C. Chen, 2020, Tetrahedron.

The Olefin Metathesis Approach to Epothilone A and Its Analogues

K. Nicolaou, D. Vourloumis, Zhen Yang, 1997 .

Elucidation of a Sequential Iminium Ion Cascade Reaction Triggered by a Silica Gel-Promoted Aza-Peterson Reaction.

S. Wright, Stefan France, Doris C. Chen, 2020, The Journal of organic chemistry.

MEK inhibitors: a patent review 2008 – 2010

J. I. Trujillo, J. Trujillo, 2011, Expert opinion on therapeutic patents.

CorrigendumCorrigendum to “Novel tetrahydro-β-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)” [Bioorg. Med. Chem. Lett. 17 (2007) 4657–4663]

David R. Anderson, D. Reitz, Matthew W. Mahoney, 2009 .

An Efficient and RegioselectiveDifluoromethylation of 3-Iodoindazole with Chlorodifluoromethane

A. Thorarensen, M. Pelc, S. R. Turner, 2010 .

Nickel-Mediated Enantioselective Piperidine Synthesis

P. Richardson, J. Trujillo, 2021, Synfacts.

Synthesis of ( R )- and ( S )-α-trifluoromethyl propanoic acids via asymmetric hydrogenation followed by salt resolution

N. Sach, O. Fadeyi, R. Unwalla, 2016 .

Design and synthesis of novel CCR2 antagonists: investigation of non-aryl/heteroaryl binding motifs.

D. J. Rogier, Wei Huang, R. Devraj, 2011, Bioorganic & medicinal chemistry letters.

2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: design and synthesis of a potent and isoform selective PKC-zeta inhibitor.

R. Compton, Wei Huang, A. Thorarensen, 2009, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of pyrazinones containing novel P1 needles as inhibitors of TF/VIIa.

D. J. Garland, D. Reitz, Wei Huang, 2007, Bioorganic & medicinal chemistry letters.