Guilian Xu

发表

Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase

Joanna L. Jankowsky, Nancy A. Jenkins, D. Borchelt, 2004 .

Cytosolic proteins lose solubility as amyloid deposits in a transgenic mouse model of Alzheimer-type amyloidosis.

D. Borchelt, S. Stevens, B. Moore, 2013, Human molecular genetics.

Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy

L. Petrucelli, D. Borchelt, D. Dickson, 2013, Acta Neuropathologica.

Lipid Receptor G2A-Mediated Signal Pathway Plays a Critical Role in Inflammatory Response by Promoting Classical Macrophage Activation

Mingyao Liu, Dali Li, B. Zheng, 2021, The Journal of Immunology.

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.

D. Borchelt, S. Younkin, L. Younkin, 2004, Human molecular genetics.

High Molecular Weight Complexes of Mutant Superoxide Dismutase 1: Age-Dependent and Tissue-Specific Accumulation

D. Borchelt, Jiou Wang, Guilian Xu, 2002, Neurobiology of Disease.

Reversible Pathologic and Cognitive Phenotypes in an Inducible Model of Alzheimer-Amyloidosis

D. Borchelt, A. Savonenko, T. Golde, 2013, The Journal of Neuroscience.

Normal cognitive behavior in two distinct congenic lines of transgenic mice hyperexpressing mutant APPSWE

D. Borchelt, D. Price, A. Savonenko, 2003, Neurobiology of Disease.

BACE1, a Major Determinant of Selective Vulnerability of the Brain to Amyloid-β Amyloidogenesis, is Essential for Cognitive, Emotional, and Synaptic Functions

H. Cai, H. Wen, D. Borchelt, 2005, The Journal of Neuroscience.

Experimental transmissibility of mutant SOD1 motor neuron disease

Jacob I. Ayers, D. Borchelt, Guilian M. Xu, 2014, Acta Neuropathologica.

Mapping superoxide dismutase 1 domains of non‐native interaction: roles of intra‐ and intermolecular disulfide bonding in aggregation

D. Borchelt, Jiou Wang, Guilian Xu, 2006, Journal of neurochemistry.

Fibrillar Inclusions and Motor Neuron Degeneration in Transgenic Mice Expressing Superoxide Dismutase 1 with a Disrupted Copper-Binding Site

D. Borchelt, N. Jenkins, V. Gonzales, 2002, Neurobiology of Disease.

Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions

D. Borchelt, T. Golde, P. Cruz, 2013, Brain Research.

Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease

D. Borchelt, B. Giasson, Jada Lewis, 2018, Acta Neuropathologica.

Vulnerability of newly synthesized proteins to proteostasis stress

D. Borchelt, Amrutha Pattamatta, Hilda H. Brown, 2016, Journal of Cell Science.

Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy

D. Borchelt, M. Swanson, Jada Lewis, 2018, Scientific Reports.

Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgenic SPAM mice

D. Borchelt, T. Golde, M. Tansey, 2022, Communications Biology.

Correction: Identification of Proteins Sensitive to Thermal Stress in Human Neuroblastoma and Glioma Cell Lines

D. Borchelt, M. Gold, S. Stevens, 2012, PLoS ONE.

Deficiency of CD40 Reveals an Important Role for LIGHT in Anti-Leishmania Immunity

yang-xin fu, Haidong Tang, Guilian M. Xu, 2015, The Journal of Immunology.

Leishmania Role for LIGHT in Anti-Deficiency of CD40 Reveals an Important

yang-xin fu, Haidong Tang, Guilian M. Xu, 2015 .

Immunity Leishmania Role for LIGHT in Anti-Deficiency of CD 40 Reveals an Important

yang-xin fu, Haidong Tang, Guilian M. Xu, 2015 .

LIGHT Is Critical for IL-12 Production by Dendritic Cells, Optimal CD4+ Th1 Cell Response, and Resistance to Leishmania major1

yang-xin fu, S. Kung, Guilian M. Xu, 2007, The Journal of Immunology.

Lymphotoxin αβ2 (Membrane Lymphotoxin) Is Critically Important for Resistance to Leishmania major Infection in Mice1

yang-xin fu, Guilian M. Xu, Yijun Fan, 2007, The Journal of Immunology.

Environmental Enrichment Mitigates Cognitive Deficits in a Mouse Model of Alzheimer's Disease

D. Borchelt, A. Savonenko, S. Younkin, 2005, The Journal of Neuroscience.

Environmental Enrichment Exacerbates Amyloid Plaque Formation in a Transgenic Mouse Model of Alzheimer Disease

D. Borchelt, V. Gonzales, J. Jankowsky, 2003, Journal of neuropathology and experimental neurology.

Coincident thresholds of mutant protein for paralytic disease and protein aggregation caused by restrictively expressed superoxide dismutase cDNA

D. Borchelt, N. Jenkins, V. Gonzales, 2005, Neurobiology of Disease.

The Histone Methyltransferase Smyd2 Is a Negative Regulator of Macrophage Activation by Suppressing Interleukin 6 (IL-6) and Tumor Necrosis Factor α (TNF-α) Production

Xi Chen, S. Xiong, B. Zheng, 2015, The Journal of Biological Chemistry.

Receptor-Associated Protein (RAP) Plays a Central Role in Modulating Aβ Deposition in APP/PS1 Transgenic Mice

D. Borchelt, Nianwei Lin, Ning Li, 2008, PloS one.

Combinatorial model of amyloid β and tau reveals synergy between amyloid deposits and tangle formation

Kristen R. Ibanez, Paramita Chakrabarty, B. Giasson, 2021, Neuropathology and applied neurobiology.

Aberrant accrual of BIN1 near Alzheimer’s disease amyloid deposits in transgenic models

Richard C. Rice, D. Borchelt, D. Nicholson, 2018, Brain pathology.

Amyloid precursor protein increases cortical neuron size in transgenic mice

D. Borchelt, A. Savonenko, J. Troncoso, 2009, Neurobiology of Aging.

Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: Relationships to β-amyloid deposition and neurotransmitter abnormalities

D. Borchelt, A. Savonenko, V. Gonzales, 2005, Neurobiology of Disease.

Alzheimer's-Type Amyloidosis in Transgenic Mice Impairs Survival of Newborn Neurons Derived from Adult Hippocampal Neurogenesis

C. Rampon, D. Borchelt, J. Jankowsky, 2007, The Journal of Neuroscience.

Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits

D. Borchelt, T. Golde, Guilian M. Xu, 2015, Acta neuropathologica communications.

Transgenic mouse models of neurodegenerative disease: Opportunities for therapeutic development

Alena Savonenko, D. Borchelt, A. Savonenko, 2002, Current neurology and neuroscience reports.

Abeta deposition does not cause the aggregation of endogenous tau in transgenic mice.

D. Borchelt, V. Gonzales, Guilian M. Xu, 2002, Alzheimer disease and associated disorders.

A Deposition Does Not Cause the Aggregation of Endogenous Tau in Transgenic Mice

D. Borchelt, V. Gonzales, Guilian M. Xu, 2002 .

TAPPing into the potential of inducible tau/APP transgenic mice

D. Borchelt, Jada Lewis, Guilian M. Xu, 2022, Neuropathology and applied neurobiology.

Soluble brain homogenates from diverse human and mouse sources preferentially seed diffuse Aβ plaque pathology when injected into newborn mouse hosts.

Hunter S. Futch, D. Borchelt, T. Golde, 2021, Free neuropathology.

Deficiency of LIGHT signaling pathway exacerbates Chlamydia psittaci respiratory tract infection in mice.

Guilian M. Xu, Lili Chen, Chunxue Lu, 2016, Microbial pathogenesis.

Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative.

D. Borchelt, Andrew T. N. Tebbenkamp, R. Mandel, 2011, Human molecular genetics.

Proteostasis and Secondary Proteinopathy in Alzheimer's Disease

D. Borchelt, L. Notterpek, Jada Lewis, 2014 .

Identification of Proteins Sensitive to Thermal Stress in Human Neuroblastoma and Glioma Cell Lines

D. Borchelt, M. Gold, S. Stevens, 2012, PloS one.

Somatodendritic accumulation of misfolded SOD1-L126Z in motor neurons mediates degeneration: alphaB-crystallin modulates aggregation.

D. Borchelt, N. Jenkins, Hong Li, 2005, Human molecular genetics.

Impact of APOE genotype on prion-type propagation of tauopathy

D. Borchelt, Paramita Chakrabarty, B. Giasson, 2022, Acta neuropathologica communications.

Behavioral abnormalities in APPSwe/PS1dE9 mouse model of AD-like pathology: comparative analysis across multiple behavioral domains

D. Borchelt, C. Janus, Guilian Xu, 2015, Neurobiology of Aging.

Substantially elevating the levels of αB‐crystallin in spinal motor neurons of mutant SOD1 mice does not significantly delay paralysis or attenuate mutant protein aggregation

D. Borchelt, Zoe B Siemienski, Keith W Crosby, 2015, Journal of neurochemistry.

Modeling the Competition between Misfolded Aβ Conformers That Produce Distinct Types of Amyloid Pathology in Alzheimer’s Disease

D. Borchelt, Guilian M. Xu, S. Fromholt, 2022, Biomolecules.

Bcl6 modulates innate immunity by controlling macrophage activity and plays critical role in experimental autoimmune encephalomyelitis

Mingyao Liu, Dali Li, Lei Zhou, 2020, European journal of immunology.

Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases

Jacob I. Ayers, D. Borchelt, J. Troncoso, 2014, Acta Neuropathologica Communications.

Lactic Acid Induces Aberrant Amyloid Precursor Protein Processing by Promoting Its Interaction with Endoplasmic Reticulum Chaperone Proteins

Guilian M. Xu, Kirsten A Weigel-Van Aken, Y. Xiang, 2010, Alzheimer's & Dementia.

Reduction of low-density lipoprotein receptor-related protein (LRP1) in hippocampal neurons does not proportionately reduce, or otherwise alter, amyloid deposition in APPswe/PS1dE9 transgenic mice

D. Borchelt, S. Fromholt, Guilian Xu, 2012, Alzheimer's Research & Therapy.

Novel SOD1 monoclonal antibodies against the electrostatic loop preferentially detect misfolded SOD1 aggregates

Jacob I. Ayers, D. Borchelt, B. Giasson, 2020, Neuroscience Letters.

Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence

Jacob I. Ayers, D. Borchelt, Guilian M. Xu, 2021, Acta Neuropathologica Communications.

Direct and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice.

D. Borchelt, Guilian M. Xu, S. Fromholt, 2015, Human molecular genetics.

Complement and the Alternative Pathway Play an Important Role in LPS/D-GalN-Induced Fulminant Hepatic Failure

Yuzhang Wu, Yusen Zhou, Guangyu Zhao, 2011, PloS one.

Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology

D. Borchelt, B. Giasson, Jada Lewis, 2018, Molecular neurodegeneration.

Experimental mutagenesis of huntingtin to map cleavage sites: different outcomes in cell and mouse models.

D. Borchelt, Andrew T. N. Tebbenkamp, L. Tessarollo, 2014, Journal of Huntington's disease.

Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases

D. Borchelt, J. Troncoso, P. Hart, 2014, Acta neuropathologica communications.

Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid β peptide in APPswe transgenic mice

D. Borchelt, D. Price, V. Koliatsos, 2003, Neurobiology of Disease.

Comment on “ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models”

D. Borchelt, T. Golde, K. Felsenstein, 2013, Science.

Diversity in Aβ deposit morphology and secondary proteome insolubility across models of Alzheimer-type amyloidosis

D. Borchelt, T. Golde, Paramita Chakrabarty, 2020, Acta Neuropathologica Communications.

Hyper-expression of human apolipoprotein E4 in astroglia and neurons does not enhance amyloid deposition in transgenic mice.

D. Borchelt, D. Price, P. Wong, 2001, Human molecular genetics.

Multiple Factors Influence the Incubation Period of ALS Prion-like Transmission in SOD1 Transgenic Mice

Jacob I. Ayers, D. Borchelt, S. Fromholt, 2023, Viruses.

Rapid detection of protein aggregates in the brains of Alzheimer patients and transgenic mouse models of amyloidosis.

D. Borchelt, V. Gonzales, Guilian Xu, 2002, Alzheimer disease and associated disorders.

Amyloid precursor protein increases cortical neuron size in transgenic mice

D. Borchelt, A. Savonenko, J. Troncoso, 2009, Neurobiology of Aging.

Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease

D. Borchelt, B. Giasson, Jada Lewis, 2018, Acta Neuropathologica.