M. Zhu

发表

Identifying potential anti-COVID-19 pharmacological components of traditional Chinese medicine Lianhuaqingwen capsule based on human exposure and ACE2 biochromatography screening

Mingshe Zhu, Yunlong Wu, Caisheng Wu, 2020, Acta Pharmaceutica Sinica B.

Artificial intelligence and network pharmacology based investigation of pharmacological mechanism and substance basis of Xiaokewan in treating diabetes.

Mingshe Zhu, Caisheng Wu, Tingting Cai, 2020, Pharmacological research.

Renal Excretion of Dabigatran: The Potential Role of Multidrug and Toxin Extrusion (MATE) Proteins.

A. D. Rodrigues, P. Marathe, M. Yao, 2019, Molecular pharmaceutics.

Applications of mass spectrometry in drug metabolism: 50 years of progress*

Mingshe Zhu, B. Wen, M. Zhu, 2015, Drug metabolism reviews.

Drug Metabolite Profiling and Identification by High-resolution Mass Spectrometry*

Mingshe Zhu, W Griffith Humphreys, W. Humphreys, 2011, The Journal of Biological Chemistry.

Amlodipine Metabolism in Human Liver Microsomes and Roles of CYP3A4/5 in the Dihydropyridine Dehydrogenation

Mingshe Zhu, Yanlin Zhu, Fen Wang, 2014, Drug Metabolism and Disposition.

Biotransformation of Ilaprazole in Human Liver Microsomes and Human: Role of CYP3A4 in Ilaprazole Clearance and Drug-Drug Interaction

Fen Wang, Wei Tang, Jie Pu, 2018, Drug Metabolism and Disposition.

Analysis of low level radioactive metabolites in biological fluids using high-performance liquid chromatography with microplate scintillation counting: method validation and application.

Weiping Zhao, J. Mitroka, N. Vázquez, 2005, Journal of pharmaceutical and biomedical analysis.

Integrated strategies for assessment of metabolite exposure in humans during drug development: analytical challenges and clinical development considerations.

Mingshe Zhu, Donglu Zhang, Haiying Zhang, 2009, Biopharmaceutics & drug disposition.

High-resolution mass spectrometry-based data acquisition and data-mining technologies for detecting and characterizing drug metabolites and traditional Chinese medicine components

Qian Ruan, Mingshe Zhu, Shuguang Ma, 2020 .

Rapid detection and structural characterization of verapamil metabolites in rats by UPLC-MSE and UNIFI platform.

Mingshe Zhu, Caisheng Wu, Hui Wang, 2019, Biomedical chromatography : BMC.

Mass defect profiles of biological matrices and the general applicability of mass defect filtering for metabolite detection.

Donglu Zhang, Mingshe Zhu, Haiying Zhang, 2008, Rapid communications in mass spectrometry : RCM.

Rapid screening and characterization of drug metabolites using a multiple ion monitoring-dependent MS/MS acquisition method on a hybrid triple quadrupole-linear ion trap mass spectrometer.

W. Humphreys, Mingshe Zhu, M. Yao, 2008, Journal of mass spectrometry : JMS.

Chapter 9 Quantification and structural elucidation of low quantities of radiolabeled metabolites using microplate scintillation counting (msc) techniques in conjunction with lc-ms

Mingshe Zhu, Donglu Zhang, G. Skiles, 2005 .

Detection and characterization of ticlopidine conjugates in rat bile using high-resolution mass spectrometry: applications of various data acquisition and processing tools.

Mingshe Zhu, J. Xing, Q. Ruan, 2013, Journal of mass spectrometry : JMS.

Mass defect filter technique and its applications to drug metabolite identification by high-resolution mass spectrometry.

Donglu Zhang, Mingshe Zhu, Haiying Zhang, 2009, Journal of mass spectrometry : JMS.

An integrated method for metabolite detection and identification using a linear ion trap/Orbitrap mass spectrometer and multiple data processing techniques: application to indinavir metabolite detection.

Scott Peterman, Qian Ruan, Mingshe Zhu, 2008, Journal of mass spectrometry : JMS.

Metabolic disposition of [14C]‐abivertinib, an epidermal growth factor receptor tyrosine kinase inhibitor: Role of glutathione conjugation

Mingshe Zhu, R. Guo, Y. Shu, 2020, British journal of clinical pharmacology.

A novel high-throughput automated chip-based nanoelectrospray tandem mass spectrometric method for PAMPA sample analysis.

S. Chong, Mingshe Zhu, P. Balimane, 2005, Journal of pharmaceutical and biomedical analysis.

Use of Triple Quadrupole–Linear Ion Trap Mass Spectrometry as a Single LC–MS Platform in Drug Metabolism and Pharmacokinetics Studies

Mingshe Zhu, Wenying Jian, M. Yao, 2011 .

An algorithm for thorough background subtraction from high-resolution LC/MS data: application to the detection of troglitazone metabolites in rat plasma, bile, and urine.

Mingshe Zhu, K. He, Haiying Zhang, 2008, Journal of mass spectrometry : JMS.

Chapter 3 Applications of Quadrupole-Linear Ion Trap Mass Spectrometry to the Analysis of Reactive Metabolites in Drug Discovery and Development

Mingshe Zhu, B. Wen, M. Zhu, 2009 .

High-throughput screening and characterization of reactive metabolites using polarity switching of hybrid triple quadrupole linear ion trap mass spectrometry.

Mingshe Zhu, S. Nelson, Li Ma, 2008, Analytical chemistry.

Detection and structural characterization of glutathione-trapped reactive metabolites using liquid chromatography-high-resolution mass spectrometry and mass defect filtering.

Mingshe Zhu, W Griffith Humphreys, W. Humphreys, 2007, Analytical chemistry.

A rapid and sensitive LC/MS/MS assay for quantitative determination of digoxin in rat plasma.

S. Chong, R. Morrison, Hongjiang Zhang, 2003, Journal of pharmaceutical and biomedical analysis.

Quantitative Bioanalysis of Proteins by Mass Spectrometry

Mingshe Zhu, Long Yuan, M. Zhu, 2015 .

Rapid screening and characterization of drug metabolites using multiple ion monitoring dependent product ion scan and postacquisition data mining on a hybrid triple quadrupole-linear ion trap mass spectrometer.

E. Duchoslav, M. Yao, Li Ma, 2009, Rapid communications in mass spectrometry : RCM.

Metabolism of synthetic cannabinoids PB-22 and its 5-fluoro analog, 5F-PB-22, by human hepatocyte incubation and high-resolution mass spectrometry

M. Huestis, K. Scheidweiler, A. Wohlfarth, 2014, Analytical and Bioanalytical Chemistry.

Pentylindole/Pentylindazole Synthetic Cannabinoids and Their 5-Fluoro Analogs Produce Different Primary Metabolites: Metabolite Profiling for AB-PINACA and 5F-AB-PINACA

M. Castaneto, M. Huestis, R. Kronstrand, 2015, The AAPS Journal.

First metabolic profile of XLR-11, a novel synthetic cannabinoid, obtained by using human hepatocytes and high-resolution mass spectrometry.

Marilyn A Huestis, Mingshe Zhu, M. Huestis, 2013, Clinical chemistry.

First Characterization of AKB-48 Metabolism, a Novel Synthetic Cannabinoid, Using Human Hepatocytes and High-Resolution Mass Spectrometry

M. Huestis, K. Scheidweiler, A. Wohlfarth, 2013, The AAPS Journal.

High-resolution mass spectrometric metabolite profiling of a novel synthetic designer drug, N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide (STS-135), using cryopreserved human hepatocytes and assessment of metabolic stability with human liver microsomes.

Mingshe Zhu, M. Castaneto, M. Huestis, 2015, Drug testing and analysis.

In vitro and in vivo human metabolism of a new synthetic cannabinoid NM-2201 (CBL-2201)

Mingshe Zhu, M. Huestis, R. Kronstrand, 2016, Forensic Toxicology.

Metabolism of the new synthetic cannabinoid EG-018 in human hepatocytes by high-resolution mass spectrometry

M. Huestis, X. Diao, J. Carlier, 2018, Forensic Toxicology.

Human Hepatocyte Metabolism of Novel Synthetic Cannabinoids MN-18 and Its 5-Fluoro Analog 5F-MN-18.

Mingshe Zhu, M. Huestis, X. Diao, 2017, Clinical chemistry.

Identification of AB-FUBINACA metabolites in human hepatocytes and urine using high-resolution mass spectrometry

Mingshe Zhu, M. Castaneto, M. Huestis, 2015, Forensic Toxicology.

Strategies to distinguish new synthetic cannabinoid FUBIMINA (BIM-2201) intake from its isomer THJ-2201: metabolism of FUBIMINA in human hepatocytes

Mingshe Zhu, M. Huestis, K. Scheidweiler, 2016, Forensic Toxicology.

Pentylindole/Pentylindazole Synthetic Cannabinoids and Their 5-Fluoro Analogs Produce Different Primary Metabolites: Metabolite Profiling for AB-PINACA and 5F-AB-PINACA

Mingshe Zhu, M. Castaneto, M. Huestis, 2015, The AAPS Journal.

Metabolite profiling of RCS-4, a novel synthetic cannabinoid designer drug, using human hepatocyte metabolism and TOF-MS.

Mingshe Zhu, M. Huestis, K. Scheidweiler, 2014, Bioanalysis.

Metabolism of RCS-8, a synthetic cannabinoid with cyclohexyl structure, in human hepatocytes by high-resolution MS.

Mingshe Zhu, M. Huestis, K. Scheidweiler, 2014, Bioanalysis.

LC‐MS in Drug Metabolism and Pharmacokinetics: A Pharmaceutical Industry Perspective

Mingshe Zhu, Naidong Weng, Wenying Jian, 2012 .

Screening and identification of GSH-trapped reactive metabolites using hybrid triple quadruple linear ion trap mass spectrometry.

W. Humphreys, Mingshe Zhu, T. Olah, 2007, Chemical research in toxicology.

High-Throughput Metabolic Soft-Spot Identification in Liver Microsomes by LC/UV/MS: Application of a Single Variable Incubation Time Approach

Hongliang Jiang, Weiqing Chen, Chang Chen, 2022, Molecules.

Comparative Metabolism of Radiolabeled Muraglitazar in Animals and Humans by Quantitative and Qualitative Metabolite Profiling

W. Humphreys, Haiying Zhang, Litao Zhang, 2007, Drug Metabolism and Disposition.

Amide N-glucuronidation of MaxiPost catalyzed by UDP-glucuronosyltransferase 2B7 in humans.

Mingshe Zhu, V. Roongta, Donglu Zhang, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Protein covalent binding of maxipost through a cytochrome P450-mediated ortho-quinone methide intermediate in rats.

Mingshe Zhu, V. Roongta, M. Ogan, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Drug Metabolism in Drug Design and Development

W. Humphreys, Donglu Zhang, M. Zhu, 2007 .

Fast and Reliable CYP Inhibition Assays

M. Yao, Hong Cai, M. Zhu, 2012 .

Development and full validation of six inhibition assays for five major cytochrome P450 enzymes in human liver microsomes using an automated 96-well microplate incubation format and LC-MS/MS analysis.

A. D. Rodrigues, W. Humphreys, R. Dai, 2007, Journal of pharmaceutical and biomedical analysis.

Recent advances in applications of liquid chromatography-tandem mass spectrometry to the analysis of reactive drug metabolites.

Mingshe Zhu, Shuguang Ma, M. Zhu, 2009, Chemico-biological interactions.

Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s.

Li Ma, B. Wen, M. Zhu, 2008, Chemico-biological interactions.

A strategy for metabolite identification using triple-quadrupole mass spectrometry with enhanced resolution and accurate mass capability.

Zheng Ouyang, Mohammed Jemal, Mingshe Zhu, 2003, Rapid communications in mass spectrometry : RCM.

Rapid screening of glutathione-trapped reactive metabolites by linear ion trap mass spectrometry with isotope pattern-dependent scanning and postacquisition data mining.

Mingshe Zhu, Q. Ruan, Li Ma, 2008, Chemical research in toxicology.

An integrated approach for profiling oxidative metabolites and glutathione adducts using liquid chromatography coupled with ultraviolet detection and triple quadrupole-linear ion trap mass spectrometry.

Hongliang Jiang, Zhongzhe Cheng, Guiying Chen, 2016, Journal of pharmaceutical and biomedical analysis.

Drug Metabolite Identification with High‐resolution Mass Spectrometry

Mingshe Zhu, Haiying Zhang, M. Zhu, 2014 .

An Integrated Approach for Studying Exposure, Metabolism, and Disposition of Multiple Component Herbal Medicines Using High-Resolution Mass Spectrometry and Multiple Data Processing Tools

Mingshe Zhu, Caisheng Wu, Haiying Zhang, 2016, Drug Metabolism and Disposition.

Strategy and its implications of protein bioanalysis utilizing high-resolution mass spectrometric detection of intact protein.

W. Humphreys, Mingshe Zhu, Q. Ruan, 2011, Analytical chemistry.

LC-MS Differential Analysis for Fast and Sensitive Determination of Biotransformation of Therapeutic Proteins

Lingjun Li, M. Yao, Bingming Chen, 2018, Drug Metabolism and Disposition.

Metabolomics-based parallel discovery of xenobiotics and induced endogenous metabolic dysregulation in clinical toxicology.

Mingshe Zhu, Xiaojie Tan, Ziquan Fan, 2018, Biomedical chromatography : BMC.

High‐Resolution LC–MS‐Based Mass Defect Filter Approach: Basic Concept and Application in Metabolite Detection

Haiying Zhang, Donglu Zhang, K. Ray, 2008 .

Discovering drugs through biological transformation: role of pharmacologically active metabolites in drug discovery.

W. Humphreys, A. Fura, Y. Shu, 2004, Journal of medicinal chemistry.

Detection and Characterization of Metabolites in Biological Matrices Using Mass Defect Filtering of Liquid Chromatography/High Resolution Mass Spectrometry Data

Donglu Zhang, Mingshe Zhu, W Griffith Humphreys, 2006, Drug Metabolism and Disposition.

The application of high-resolution mass spectrometry-based data-mining tools in tandem to metabolite profiling of a triple drug combination in humans.

Mingshe Zhu, J. Xing, Haiying Zhang, 2015, Analytica chimica acta.

Software-aided detection and structural characterization of cyclic peptide metabolites in biological matrix by high-resolution mass spectrometry

Mingshe Zhu, E. Duchoslav, Tingting Cai, 2020, Journal of pharmaceutical analysis.

Detection of Novel Reactive Metabolites of Trazodone: Evidence for CYP2D6-Mediated Bioactivation of m-Chlorophenylpiperazine

A. D. Rodrigues, Li Ma, B. Wen, 2008, Drug Metabolism and Disposition.

In vitro screening of 50 highly prescribed drugs for thiol adduct formation--comparison of potential for drug-induced toxicity and extent of adduct formation.

W. Humphreys, Mingshe Zhu, J. Gan, 2009, Chemical research in toxicology.

Bioactivation of coumarin in rat olfactory mucosal microsomes: Detection of protein covalent binding and identification of reactive intermediates through analysis of glutathione adducts.

W. Humphreys, Y. Shu, Weiping Zhao, 2009, Chemico-biological interactions.

Differential mobility spectrometry combined with multiple ion monitoring for bioanalysis of disulfide-bonded peptides with inefficient collision-induced dissociation fragmentation.

Eugene Ciccimaro, Yuan-qing Xia, Naiyu Zheng, 2017, Bioanalysis.

Untargeted screening of unknown xenobiotics and potential toxins in plasma of poisoned patients using high-resolution mass spectrometry: Generation of xenobiotic fingerprint using background subtraction.

Xin Wang, Hongliang Jiang, Yulin Feng, 2016, Analytica chimica acta.

Drug metabolism in drug design and development : basic concepts and practice

W. Humphreys, Mingshe Zhu, Donglu Zhang, 2008 .

Exploration of Q-Marker of Rhubarb Based on Intelligent Data Processing Techniques and the AUC Pooled Method

Mingshe Zhu, Caisheng Wu, Minting Liu, 2022, Frontiers in Pharmacology.

CYP2D6 CATALYZES 5-HYDROXYLATION OF 1-(2-PYRIMIDINYL)-PIPERAZINE, AN ACTIVE METABOLITE OF SEVERAL PSYCHOACTIVE DRUGS, IN HUMAN LIVER MICROSOMES

Mingshe Zhu, Donglu Zhang, Nirmala Raghavan, 2005, Drug Metabolism and Disposition.

Metabolic Pathway of Icotinib In Vitro: The Differential Roles of CYP3A4, CYP3A5, and CYP1A2 on Potential Pharmacokinetic Drug-Drug Interaction.

Chuang Lu, Xiaomei Zhuang, Zheng Li, 2017, Journal of pharmaceutical sciences.

Involvement of Multiple Cytochrome P450 and UDP-Glucuronosyltransferase Enzymes in the in Vitro Metabolism of Muraglitazar

W. Humphreys, Hongjiang Zhang, Donglu Zhang, 2007, Drug Metabolism and Disposition.

Mass Spectrometry in Drug Metabolism and Disposition: Basic Principles and Applications

Mingshe Zhu, Mike S. Lee, M. Zhu, 2011 .

STRUCTURAL ELUCIDATION OF HUMAN OXIDATIVE METABOLITES OF MURAGLITAZAR: USE OF MICROBIAL BIOREACTORS IN THE BIOSYNTHESIS OF METABOLITE STANDARDS

Yande Huang, W. Humphreys, Mingshe Zhu, 2006, Drug Metabolism and Disposition.

Allosteric activation of midazolam CYP3A5 hydroxylase activity by icotinib - Enhancement by ketoconazole.

Mingshe Zhu, Haiying Yang, Chuang Lu, 2016, Biochemical pharmacology.

Reflecting on a decade of metabolite screening and monitoring.

Jian Wang, Mark E Arnold, Anne-Françoise Aubry, 2014, Bioanalysis.

Metabolic characterization of AH-7921, a synthetic opioid designer drug: in vitro metabolic stability assessment and metabolite identification, evaluation of in silico prediction, and in vivo confirmation.

Mingshe Zhu, M. Castaneto, M. Huestis, 2016, Drug testing and analysis.

CYTOCHROME P450 3A-MEDIATED METABOLISM OF BUSPIRONE IN HUMAN LIVER MICROSOMES

Donglu Zhang, Mingshe Zhu, Renke Dai, 2005, Drug Metabolism and Disposition.

Biotransformation of Daclatasvir In Vitro and in Nonclinical Species: Formation of the Main Metabolite by Pyrrolidine δ-Oxidation and Rearrangement

W. Humphreys, L. Hamann, Y. Shu, 2016, Drug Metabolism and Disposition.

Characterization of human metabolism and disposition of levo-tetrahydropalmatine: Qualitative and quantitative determination of oxidative and conjugated metabolites.

Xiaomei Zhuang, Hua Li, Guolin Shen, 2016, Journal of Pharmaceutical and Biomedical Analysis.

In Vitro Characterization and Pharmacokinetics of Dapagliflozin (BMS-512148), a Potent Sodium-Glucose Cotransporter Type II Inhibitor, in Animals and Humans

W. Humphreys, B. Koplowitz, A. Khanna, 2010, Drug Metabolism and Disposition.

Rapid detection and characterization of in vitro and urinary N-acetyl-L-cysteine conjugates using quadrupole-linear ion trap mass spectrometry and polarity switching.

Mingshe Zhu, Wenying Jian, M. Yao, 2009, Chemical research in toxicology.

Identification and quantification of signal peptide variants in an IgG1 monoclonal antibody produced in mammalian cell lines.

Reb J. Russell, R. Ludwig, L. Tao, 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Simultaneous Screening of Glutathione and Cyanide Adducts Using Precursor Ion and Neutral Loss Scans-Dependent Product Ion Spectral Acquisition and Data Mining Tools

Mingshe Zhu, Wenying Jian, Weiping Zhao, 2012, Journal of The American Society for Mass Spectrometry.

Application of physiologically based pharmacokinetic modelling for the prediction of drug–drug interactions involving anlotinib as a perpetrator of cytochrome P450 enzymes

Mingshe Zhu, Xin'an Wu, Zhiping Jin, 2022, Basic & clinical pharmacology & toxicology.

Mass defect profiles of biological matrices and the general applicability of mass defect filtering for metabolite detection.

Haiying Zhang, Donglu Zhang, Li Ma, 2008, Rapid communications in mass spectrometry : RCM.