Julio Brito

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Nitric Oxide and Superoxide Anion Balance in Rats Exposed to Chronic and Long Term Intermittent Hypoxia

F. Léon-Velarde, P. Siques, S. Arribas, 2014, BioMed research international.

Oxidative Stress, Kinase Activation, and Inflammatory Pathways Involved in Effects on Smooth Muscle Cells During Pulmonary Artery Hypertension Under Hypobaric Hypoxia Exposure

P. Siques, E. Pena, Samia El Alam, 2021, Frontiers in Physiology.

Time course of cardiovascular and hematological responses in rats exposed to chronic intermittent hypobaric hypoxia (4600 m).

F. Léon-Velarde, P. Siques, J. Brito, 2006, High altitude medicine & biology.

AMPK and the Challenge of Treating Hypoxic Pulmonary Hypertension

P. Siques, J. Brito, S. Arribas, 2022, International journal of molecular sciences.

Chronic kidney disease in older adults

J. Brito, C. G. Gutierrez, C. Cruz, 2020, Urology & Nephrology Open Access Journal.

Involvement of overweight and lipid metabolism in the development of pulmonary hypertension under conditions of chronic intermittent hypoxia

P. Siques, J. Brito, E. Pena, 2020, Pulmonary circulation.

Nox2 Upregulation and p38α MAPK Activation in Right Ventricular Hypertrophy of Rats Exposed to Long-Term Chronic Intermittent Hypobaric Hypoxia

F. Léon-Velarde, P. Siques, J. Brito, 2020, International journal of molecular sciences.

Chronic intermittent hypoxia at high altitude exposure for over 12 years: assessment of hematological, cardiovascular, and renal effects.

J. J. de la Cruz, F. Léon-Velarde, P. Siques, 2007, High altitude medicine & biology.

Oxidative Stress, Kinase Activity and Inflammatory Implications in Right Ventricular Hypertrophy and Heart Failure under Hypobaric Hypoxia

P. Siques, E. Pena, Samia El Alam, 2020, International journal of molecular sciences.

Oxidative Stress and Diseases Associated with High-Altitude Exposure

P. Siques, J. Brito, E. Pena, 2022, Antioxidants.

Inflammation in Pulmonary Hypertension and Edema Induced by Hypobaric Hypoxia Exposure

P. Siques, J. Brito, E. Pena, 2022, International journal of molecular sciences.

Reactive Oxygen Species and Pulmonary Vasculature During Hypobaric Hypoxia

P. Siques, J. Brito, E. Pena, 2018, Front. Physiol..

Impact of Zinc on Oxidative Signaling Pathways in the Development of Pulmonary Vasoconstriction Induced by Hypobaric Hypoxia

P. Siques, J. Brito, E. Pena, 2022, International journal of molecular sciences.

Reactive Oxygen Species at High Altitude (Hypobaric Hypoxia) on the Cardiovascular System

P. Siques, J. Brito, E. Pena, 2017 .

Long-term chronic intermittent hypoxia: a particular form of chronic high-altitude pulmonary hypertension

P. Siques, J. Brito, E. Pena, 2020, Pulmonary circulation.

Lower Body Weight in Rats Under Hypobaric Hypoxia Exposure Would Lead to Reduced Right Ventricular Hypertrophy and Increased AMPK Activation

F. Léon-Velarde, P. Siques, E. Pena, 2020, Frontiers in Physiology.

Adventitial Alterations Are the Main Features in Pulmonary Artery Remodeling due to Long-Term Chronic Intermittent Hypobaric Hypoxia in Rats

F. Léon-Velarde, P. Siques, S. Arribas, 2015, BioMed research international.

Asymmetric Dimethylarginine at Sea Level Is a Predictive Marker of Hypoxic Pulmonary Arterial Hypertension at High Altitude

J. J. de la Cruz, F. Léon-Velarde, P. Siques, 2019, Front. Physiol..

Long-Term Chronic Intermittent Hypobaric Hypoxia Induces Glucose Transporter (GLUT4) Translocation Through AMP-Activated Protein Kinase (AMPK) in the Soleus Muscle in Lean Rats

F. Léon-Velarde, P. Siques, E. Pena, 2018, Front. Physiol..

Upregulation of arginase expression and activity in hypertensive rats exposed to chronic intermittent hypobaric hypoxia.

F. Léon-Velarde, P. Siques, J. Brito, 2009, High altitude medicine & biology.

Obesity as a Conditioning Factor for High-Altitude Diseases

Julio Brito, F. Léon-Velarde, P. Siques, 2017, Obesity Facts.

Blood pressure responses in young adults first exposed to high altitude for 12 months at 3550 m.

F. Léon-Velarde, J. Banegas, P. Siques, 2009, High altitude medicine & biology.

Long-Term Chronic Intermittent Hypobaric Hypoxia in Rats Causes an Imbalance in the Asymmetric Dimethylarginine/Nitric Oxide Pathway and ROS Activity: A Possible Synergistic Mechanism for Altitude Pulmonary Hypertension?

F. Léon-Velarde, H. Klose, P. Siques, 2016, Pulmonary medicine.

Association of Genes of the NO Pathway with Altitude Disease and Hypoxic Pulmonary Hypertension

P. Siques, R. Böger, J. Hannemann, 2021, Journal of clinical medicine.

Sustained acclimatization in Chilean mine workers subjected to chronic intermittent hypoxia.

P. Siques, J. Farías, J. Reyes, 2006, High altitude medicine & biology.

Hematological and lipid profile changes in sea-level natives after exposure to 3550-m altitude for 8 months.

J. J. de la Cruz, F. Léon-Velarde, P. Siques, 2007, High altitude medicine & biology.

Pre-Analytical and Clinical Validation of a Dried Blood Spot Assay for Asymmetric Dimethylarginine and L-Arginine

P. Siques, J. Brito, R. Böger, 2020, Journal of clinical medicine.

Intermittent work at high altitude: a new epidemiological situation

F. Léon-Velarde, P. Siques, Julio Brito, 2007 .

Long-Term Intermittent Work at High Altitude: Right Heart Functional and Morphological Status and Associated Cardiometabolic Factors

F. Léon-Velarde, P. Siques, R. Böger, 2018, Front. Physiol..

Effects of Zinc on the Right Cardiovascular Circuit in Long-Term Hypobaric Hypoxia in Wistar Rats

P. Siques, S. Arribas, M. R. López, 2023, International journal of molecular sciences.

Long-Term Intermittent Exposure to High Altitude Elevates Asymmetric Dimethylarginine in First Exposed Young Adults

J. J. de la Cruz, F. Léon-Velarde, P. Siques, 2017, High altitude medicine & biology.

Varying exposure regimes to long term chronic intermittent hypoxia exert different outcomes and morphological effects on Wistar rats at 4600 m

F. Léon-Velarde, P. Siques, R. Herruzo, 2008 .

Plasma and liver lipid profiles in rats exposed to chronic hypobaric hypoxia: changes in metabolic pathways.

P. Siques, SiquesPatricia, BritoJulio, 2014, High altitude medicine & biology.

Relation of Breast Cancer and Malathion Aerial Spraying in Arica, Chile

P. Siques, E. Parra, Gertrudis Cabello, 2013 .