Jian‐Sung Wu

发表

Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity.

Ping-Chiang Lyu, Mohane Selvaraj Coumar, Yu-Sheng Chao, 2009, Journal of medicinal chemistry.

Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules

Chi-Ying F. Huang, Yi-Hui Peng, H. Hsieh, 2013, Proceedings of the National Academy of Sciences.

Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor lead identification.

Santhosh Kumar Chittimalla, Yi-Hui Peng, H. Hsieh, 2010, Journal of medicinal chemistry.

Identification, SAR Studies, and X‐ray Co‐crystallographic Analysis of a Novel Furanopyrimidine Aurora Kinase A Inhibitor

H. Hsieh, Y. Chao, J. Hsu, 2010, ChemMedChem.

Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: the role of the DFG motif in the design of epidermal growth factor receptor inhibitors.

P. Lyu, Yi-Hui Peng, H. Hsieh, 2013, Journal of medicinal chemistry.

Synthesis and biological evaluation of 1-(4'-Indolyl and 6'-Quinolinyl) indoles as a new class of potent anticancer agents.

H. Hsieh, Su-Ying Wu, Jian-Sung Wu, 2011, European journal of medicinal chemistry.

Furanylazaindoles: potent anticancer agents in vitro and in vivo.

Su-Ying Wu, Jian-Sung Wu, S. Pan, 2013, Journal of medicinal chemistry.

Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2,3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening.

Yi-Hui Peng, A. Yueh, J. Hsu, 2015, Journal of medicinal chemistry.

Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors.

Y. Chao, Su-Ying Wu, Jian-Sung Wu, 2014, Bioorganic & medicinal chemistry letters.

Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1.

Su-Ying Wu, Jian-Sung Wu, Yi-Hui Peng, 2016, Journal of medicinal chemistry.

Pyrazolylamine Derivatives Reveal the Conformational Switching between Type I and Type II Binding Modes of Anaplastic Lymphoma Kinase (ALK).

P. Lyu, Yi-Hui Peng, Su-Ying Wu, 2016, Journal of medicinal chemistry.

Cancer Cells Acquire Mitotic Drug Resistance Properties Through Beta I-Tubulin Mutations and Alterations in the Expression of Beta-Tubulin Isotypes

H. Hsieh, Su-Ying Wu, Jian-Sung Wu, 2010, PloS one.

Discovery of non-glycoside sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors by ligand-based virtual screening.

Yi-Hui Peng, C. Chen, Y. Chao, 2010, Journal of medicinal chemistry.

Scaffold-hopping strategy: synthesis and biological evaluation of 5,6-fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents.

H. Hsieh, C. Liao, Su-Ying Wu, 2011, Journal of medicinal chemistry.

Structure-based drug design of novel Aurora kinase A inhibitors: structural basis for potency and specificity.

Mohane Selvaraj Coumar, Yu-Sheng Chao, Su-Ying Wu, 2009, Journal of medicinal chemistry.

Aurora kinase A inhibitors: identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold.

H. Hsieh, Y. Chao, J. Hsu, 2008, Bioorganic & medicinal chemistry letters.

Thioether Bonded Nickel(II)‐Azoimidazole Complexes: Structures, Spectra and Electrochemical Oxidation to the Nickel(III) State

Jian-Sung Wu, A. Slawin, C. Sinha, 2009 .

Mutagenesis of Dengue Virus Protein NS2A Revealed a Novel Domain Responsible for Virus-Induced Cytopathic Effect and Interactions between NS2A and NS2B Transmembrane Segments

A. Yueh, Su-Ying Wu, Jian-Sung Wu, 2017, Journal of Virology.

Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules

Chi-Ying F. Huang, Yi-Hui Peng, H. Hsieh, 2013, Proceedings of the National Academy of Sciences.

Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists.

Mohane Selvaraj Coumar, Yu-Sheng Chao, Su-Ying Wu, 2009, Journal of medicinal chemistry.