J. Whitney

发表

Pharmacokinetics and Disposition of Momelotinib Revealed a Disproportionate Human Metabolite—Resolution for Clinical Development

M. Warr, R. Subramanian, Y. Xin, 2018, Drug Metabolism and Disposition.

Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical- basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein

M. Balda, M. Cereijido, J. A. Whitney, 1996, The Journal of cell biology.

Momelotinib inhibits ACVR1/ALK2, decreases hepcidin production, and ameliorates anemia of chronic disease in rodents.

M. Warr, K. Wagner, C. Burns, 2017, Blood.

tyrosine protein kinase. the amino-terminal domain of the p56lck domains of CD4 and CD8 mediate binding to Short related sequences in the cytoplasmic

A. Shaw, J. Rose, K. Amrein, 2013 .

Discovery of GS-9973, a selective and orally efficacious inhibitor of spleen tyrosine kinase.

H. Rong, K. Currie, J. Kropf, 2014, Journal of medicinal chemistry.

Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis.

Brandon J. Bravo, L. Diehl, S. Hymowitz, 2011, Nature chemical biology.

Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation.

J. Connolly, J. Banchereau, I. Mellman, 2007, Immunity.

Reference systems for kinase drug discovery: chemical genetic approaches to cell-based assays.

J. Whitney, 2004, Assay and drug development technologies.

Cytoplasmic coat proteins involved in endosome function

I. Mellman, D. Sheff, T. Kreis, 1995, Cell.

Common signals control low density lipoprotein receptor sorting in endosomes and the Golgi complex of MDCK cells

I. Mellman, J. A. Whitney, K. Matter, 1993, Cell.

Biogenesis of the apical endosome-lysosome complex during differentiation of absorptive epithelial cells in rat ileum.

J. Wilson, M. Neutra, J. A. Whitney, 1991, Journal of cell science.

Identification of an endosomal antigen specific to absorptive cells of suckling rat ileum

J. Wilson, M. Neutra, J. A. Whitney, 1987, The Journal of cell biology.

Brefeldin A and the endocytic pathway Possible implications for membrane traffic and sorting

I. Mellman, W. Hunziker, J. A. Whitney, 1992, FEBS letters.

P. Kavathas, A. Shaw, J. Rose, 1990, Molecular and cellular biology.

Chemical genetic transcriptional fingerprinting for selectivity profiling of kinase inhibitors.

T. Awad, M. Velleca, K. Currie, 2007, Assay and drug development technologies.

Fc receptor phosphorylation during receptor-mediated control of B-cell activation

I. Mellman, W. Hunziker, J. A. Whitney, 1990, Nature.

Intracellular Distribution of Arf Proteins in Mammalian Cells

R. Kahn, I. Mellman, M. Cavenagh, 1996, The Journal of Biological Chemistry.

Selective inhibition of transcytosis by brefeldin A in MDCK cells

I. Mellman, W. Hunziker, J. A. Whitney, 1991, Cell.

Molecular sorting in polarized and non-polarized cells: common problems, common solutions

I. Mellman, W. Hunziker, K. Matter, 1993, Journal of Cell Science.

Cloning, expression, and localization of a novel γ‐adaptin‐like molecule

J. Bonifacino, I. Mellman, D. Sheff, 1998 .

Cloning, expression, and localization of a novel gamma-adaptin-like molecule.

J. Bonifacino, I. Mellman, D. Sheff, 1998, FEBS Letters.

COPI vesicles accumulating in the presence of a GTP restricted arf1 mutant are depleted of anterograde and retrograde cargo.

R. Pepperkok, T. Kreis, M. Gomez, 2000, Journal of cell science.

Preclinical Modeling of ACVR1-Dependent Hepcidin Production and Anemia By Momelotinib

M. Warr, G. Weiss, I. Theurl, 2016 .

P294 AMT-101, a gut selective oral IL-10 fusion: results from a Phase 1b study in patients with active Ulcerative Colitis

S. Schreiber, M. Garovoy, M. Posch, 2021 .

P. Kavathas, A. Shaw, K. Amrein, 2022 .

Cell growth modulates nitric oxide synthase expression in fetal pulmonary artery endothelial cells.

I. Yuhanna, P. Shaul, J. A. Whitney, 2000, American journal of physiology. Lung cellular and molecular physiology.