Vi Pham

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Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures.

J. Åqvist, H. Gutiérrez‐de‐Terán, P. Artursson, 2016, ACS chemical neuroscience.

Identification and characterization of a new cognitive enhancer based on inhibition of insulin‐regulated aminopeptidase

Michael W Parker, Vi Pham, David B Ascher, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Insights into Interactions between the α-Helical Region of the Salmon Calcitonin Antagonists and the Human Calcitonin Receptor using Photoaffinity Labeling*

P. Sexton, M. Parker, C. Morton, 2005, Journal of Biological Chemistry.

Nesfatin‐1 is an inhibitor of the growth hormone‐insulin‐like growth factor axis in goldfish (Carassius auratus)

A. Blanco, S. Unniappan, J. Pemberton, 2021, Journal of neuroendocrinology.

Nesfatin-1 Stimulates the Hypothalamus-Pituitary-Interrenal Axis Hormones in Goldfish.

A. Blanco, S. Unniappan, J. Pemberton, 2021, American journal of physiology. Regulatory, integrative and comparative physiology.

Mu and Delta Opioid Receptors Are Coexpressed and Functionally Interact in the Enteric Nervous System of the Mouse Colon

A. Christopoulos, D. Massotte, R. A. Ceredig, 2019, Cellular and molecular gastroenterology and hepatology.

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a

Mehdi Mobli, Glenn F. King, Vi Pham, 2017, Proceedings of the National Academy of Sciences.

Interaction of the Akt substrate, AS160, with the glucose transporter 4 vesicle marker protein, insulin-regulated aminopeptidase.

S. L. Macaulay, S. Ye, A. Albiston, 2006, Molecular endocrinology.

Distinct distribution of GLUT4 and insulin regulated aminopeptidase in the mouse kidney

S. Fuller, S. Diwakarla, A. Albiston, 2011, Regulatory Peptides.

Reproduction and maternal behavior in insulin-regulated aminopeptidase (IRAP) knockout mice

P. Burns, S. Diwakarla, A. Albiston, 2009, Peptides.

Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance

D. Holtzman, S. Paul, Hong Jiang, 2009, Neuron.

Binding to and Inhibition of Insulin-Regulated Aminopeptidase by Macrocyclic Disulfides Enhances Spine Density

J. Åqvist, H. Gutiérrez‐de‐Terán, T. Lundbäck, 2016, Molecular Pharmacology.

Identification and characterization of a new cognitive enhancer based on inhibition of insulinâ•’regulated aminopeptidase

C. Morton, S. Ye, D. Ascher, 2008 .

Lack of Intra-cellular Signalling by Angiotensin IV in IRAP Transfected Cells

A. Albiston, S. Chai, Vi Pham, 2008, International Journal of Peptide Research and Therapeutics.

Identification and development of specific inhibitors for insulin‐regulated aminopeptidase as a new class of cognitive enhancers

M. Parker, J. Holien, P. Thompson, 2011, British journal of pharmacology.

Neuronal electrophysiological function and control of neurite outgrowth on electrospun polymer nanofibers are cell type dependent.

Vi Pham, J. Forsythe, H. Coleman, 2014, Tissue engineering. Part A.

Application of photoaffinity crosslinking in determining the interaction between calcitonin and its receptor

P. Sexton, J. Wade, V. Pham, 2003, Letters in Peptide Science.

Application of photoaffinity crosslinking in determining the interaction between calcitonin and its receptor

P. Sexton, J. Wade, V. Pham, 2003, Letters in Peptide Science.

Deconvoluting the Molecular Control of Binding and Signaling at the Amylin 3 Receptor: RAMP3 Alters Signal Propagation through Extracellular Loops of the Calcitonin Receptor.

P. Sexton, A. Christopoulos, C. Reynolds, 2019, ACS pharmacology & translational science.

Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy

P. Sexton, A. Christopoulos, C. Reynolds, 2018, Biochemical pharmacology.

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

P. Sexton, A. Christopoulos, A. Tobin, 2023, eLife.

Structural basis of efficacy-driven ligand selectivity at GPCRs

S. Paul, P. Sexton, A. Christopoulos, 2023, Nature Chemical Biology.

Spatial Proximity between a Photolabile Residue in Position 19 of Salmon Calcitonin and the Amino Terminus of the Human Calcitonin Receptor*

P. Sexton, J. Wade, V. Pham, 2004, Journal of Biological Chemistry.

Biased Profile of Xanomeline at the Recombinant Human M4 Muscarinic Acetylcholine Receptor.

S. Paul, A. Christopoulos, C. Felder, 2022, ACS chemical neuroscience.

Structure–activity relationship of pyrazol-4-yl-pyridine derivatives and identification of a radiofluorinated probe for imaging the muscarinic acetylcholine receptor M4

Steven H. Liang, J. Daunais, A. Christopoulos, 2022, Acta pharmaceutica Sinica. B.

Photoaffinity scanning in the mapping of the peptide receptor interface of class II G protein—coupled receptors

Patrick M Sexton, P. Sexton, V I Pham, 2004, Journal of peptide science : an official publication of the European Peptide Society.

Insulin-regulated aminopeptidase deficiency provides protection against ischemic stroke in mice.

P. Crack, Connie H. Y. Wong, S. Diwakarla, 2012, Journal of neurotrauma.

Phenylalanine-544 Plays a Key Role in Substrate and Inhibitor Binding by Providing a Hydrophobic Packing Point at the Active Site of Insulin-Regulated Aminopeptidase

M. Parker, C. Morton, J. Holien, 2010, Molecular Pharmacology.

Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR

P. Sexton, A. Christopoulos, R. Danev, 2023, Nature communications.

Social behaviour is altered in the insulin-regulated aminopeptidase knockout mouse

P. Burns, A. Albiston, S. Chai, 2019, Behavioural Brain Research.

The Design, Synthesis, and Evaluation of Novel 9-Arylxanthenedione-Based Allosteric Modulators for the δ-Opioid Receptor.

A. Christopoulos, P. Scammells, C. Valant, 2022, Journal of medicinal chemistry.

Distinct distribution of GLUT4 and insulin regulated aminopeptidase in the mouse kidney

S. Fuller, S. Diwakarla, A. Albiston, 2011, Regulatory Peptides.

Gene knockout of insulin-regulated aminopeptidase: Loss of the specific binding site for angiotensin IV and age-related deficit in spatial memory

P. Burns, S. Diwakarla, A. Albiston, 2010, Neurobiology of Learning and Memory.

Positive allosteric modulation of endogenous delta opioid receptor signaling in the enteric nervous system is a potential treatment for gut motility disorders.

A. Christopoulos, J. Fichna, N. Veldhuis, 2021, American journal of physiology. Gastrointestinal and liver physiology.

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

P. Sexton, A. Christopoulos, C. Lindsley, 2022, bioRxiv.

Phenylalanine-544 Plays a Key Role in Substrate and Inhibitor Binding by Providing a Hydrophobic Packing Point at the Active Site of Insulin-Regulated Aminopeptidase

M. Parker, C. Morton, J. Holien, 2010, Molecular Pharmacology.

Identification and characterization of a new cognitive enhancer based on inhibition of insulin‐regulated aminopeptidase

C. Morton, D. Ascher, A. Albiston, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Role of Conserved Tyrosine Lid Residues in the Activation of the M2 Muscarinic Acetylcholine Receptor

A. Christopoulos, L. Heitman, C. Valant, 2023, Molecular Pharmacology.

Inhibition of insulin-regulated aminopeptidase confers neuroprotection in a conscious model of ischemic stroke

R. Widdop, Claudia A. McCarthy, Vi Pham, 2023, Scientific reports.