Shigekazu Sasaki

发表

Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders.

H. Oki, K. Nakashima, T. Taniguchi, 2017, Journal of medicinal chemistry.

Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders.

H. Kokubo, H. Oki, T. Taniguchi, 2017, Journal of medicinal chemistry.

Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d.

S. Sogabe, Tomoya Sameshima, M. Kamaura, 2017, ACS medicinal chemistry letters.

Investigation of the structural requirements of K-Ras(G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging.

Kotaro Sakamoto, Tomoya Sameshima, M. Kamaura, 2017, Bioorganic & medicinal chemistry letters.

Design and synthesis of a novel series of orally active, selective somatostatin receptor 2 agonists for the treatment of type 2 diabetes.

J. Kunitomo, Masanori Watanabe, N. Amano, 2017, Bioorganic & medicinal chemistry.

K-Ras(G12D)-selective inhibitory peptides generated by random peptide T7 phage display technology.

Kotaro Sakamoto, S. Ohkubo, Tomoya Sameshima, 2017, Biochemical and biophysical research communications.

Reductively Cleavable Nanocaplets for siRNA Delivery by Template-Assisted Oxidative Polymerization.

T. Aida, P. K. Hashim, Yasutaka Hoashi, 2015, Journal of the American Chemical Society.

Melanin-concentrating hormone receptor 1 antagonists. Synthesis and structure-activity relationships of novel 3-(aminomethyl)quinolines.

Koki Kato, Y. Nakano, Toshio Tanaka, 2012, Journal of medicinal chemistry.

Discovery of Novel 5-(Piperazine-1-carbonyl)pyridin-2(1H)-one Derivatives as Orally eIF4A3-Selective Inhibitors.

K. Fukuda, Y. Imaeda, Y. Kosugi, 2017, ACS medicinal chemistry letters.

Potent ectopic bone-inducing activity of bone morphogenetic protein-4/7 heterodimer.

A. Aono, Y. Fujisawa, K. Notoya, 1995, Biochemical and biophysical research communications.

Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders.

H. Oki, S. Mikami, O. Ujikawa, 2017, Journal of medicinal chemistry.

Discovery of a novel series of medium-sized cyclic enteropeptidase inhibitors.

Sachiko Itono, K. Fukuda, Naohiro Taya, 2023, Bioorganic & medicinal chemistry.