Stefan Knapp

发表

Structural genomics of histone tail recognition

Matthieu Schapira, Minghua Wang, Brian D. Marsden, 2010, Bioinform..

Document S1. Tables S1–S7 and Data S1 and S2

Jun Qi, Lang, Stefan Knapp, 2012 .

The promise and peril of chemical probes.

John P. Overington, Jian Jin, Matthieu Schapira, 2015, Nature chemical biology.

Donated chemical probes for open science

Anton Simeonov, Steve Hitchcock, Stefan Laufer, 2018, eLife.

Document S2. Article plus Supplemental Information

Jun Qi, Lang, Stefan Knapp, 2012 .

Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis

Vassilios Myrianthopoulos, Emmanuel Mikros, Stefan Knapp, 2016, Journal of medicinal chemistry.

Statistical Analysis on the Performance of Molecular Mechanics Poisson–Boltzmann Surface Area versus Absolute Binding Free Energy Calculations: Bromodomains as a Case Study

Philip C Biggin, Matteo Aldeghi, Stefan Knapp, 2017, J. Chem. Inf. Model..

Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitors.

Stefan Knapp, Panagis Filippakopoulos, Jenny Bain, 2009, Journal of medicinal chemistry.

Kinase inhibitor selectivity profiling using differential scanning fluorimetry.

Stefan Knapp, Oleg Fedorov, S. Knapp, 2012, Methods in molecular biology.

Structure and Substrate Specificity of the Pim-1 Kinase*

Stefan Knapp, Benjamin E. Turk, Judit Debreczeni, 2005, Journal of Biological Chemistry.

Recently targeted kinases and their inhibitors-the path to clinical trials.

Stefan Knapp, S. Knapp, M. Sundström, 2014, Current opinion in pharmacology.

Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain

Chris Abell, Stefan Knapp, Frank von Delft, 2013, Journal of medicinal chemistry.

A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced-Fit Pocket Stabilized by a Cation–π Interaction**

Stefan Knapp, Robert S Paton, Susanne Müller, 2014, Angewandte Chemie.

Effect of Single Amino Acid Substitution Observed in Cancer on Pim-1 Kinase Thermodynamic Stability and Structure

Stefan Knapp, S. Knapp, A. Pasquo, 2013, PloS one.

Inhibition of protein–protein interactions: The discovery of druglike β‐catenin inhibitors by combining virtual and biophysical screening

Cornel Catana, Jean-Yves Trosset, Stefan Knapp, 2006, Proteins.

High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.

Randall W King, Xianming Deng, Stefan Knapp, 2011, Chemistry & biology.

Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites

Stefan Knapp, Laurence H Pearl, L. Pearl, 2008, The EMBO journal.

Small‐Molecule Modulators for Epigenetics Targets

Stefan Knapp, Hilmar Weinmann, S. Knapp, 2013, ChemMedChem.

Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome

Wen Hwa Lee, Stefan Knapp, Susanne Müller, 2009, Cell.

Crystal structure of the tetrameric Mad1–Mad2 core complex: implications of a ‘safety belt’ binding mechanism for the spindle checkpoint

Andrea Musacchio, Stefan Knapp, S. Knapp, 2002, The EMBO journal.

Structure of the SOCS4-ElonginB/C Complex Reveals a Distinct SOCS Box Interface and the Molecular Basis for SOCS-Dependent EGFR Degradation

Stefan Knapp, Zhou Songyang, S. Knapp, 2007, Structure.

Dissection of PIM serine/threonine kinases in FLT3-ITD–induced leukemogenesis reveals PIM1 as regulator of CXCL12–CXCR4-mediated homing and migration

Stefan Knapp, Andrea Biondi, Antonello Villa, 2009, The Journal of experimental medicine.

Druggability Analysis and Structural Classification of Bromodomain Acetyl-lysine Binding Sites

Nathan Brown, Lewis R. Vidler, Stefan Knapp, 2012, Journal of medicinal chemistry.

Diverse levels of sequence selectivity and catalytic efficiency of protein-tyrosine phosphatases.

Xianwen Chen, Stefan Knapp, S. Knapp, 2014, Biochemistry.

The Global Cancer Genomics Consortium: interfacing genomics and cancer medicine.

Masakazu Toi, Sudeep Gupta, Stefan Knapp, 2012, Cancer research.

A public-private partnership to unlock the untargeted kinome.

Julian Blagg, Paul Workman, Bernhard Kuster, 2013, Nature chemical biology.

1 STRUCTURE AND REGULATION OF THE HUMAN NEK 2 CENTROSOMAL KINASE

Stefan Knapp, Andrew M. Fry, Oleg Fedorov, 2006 .

SH2 domains: modulators of nonreceptor tyrosine kinase activity

Stefan Knapp, Susanne Müller, Panagis Filippakopoulos, 2009, Current opinion in structural biology.

Structure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site

Stefan Knapp, Eric D. Scheeff, Gerard Manning, 2009, Structure.

A Comparison of Protein Kinases Inhibitor Screening Methods Using Both Enzymatic Activity and Binding Affinity Determination

Lars Juhl Jensen, Stefan Knapp, L. Jensen, 2014, PloS one.

Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases

Daniel Cappel, Vassilios Myrianthopoulos, Emmanuel Mikros, 2012, ACS medicinal chemistry letters.

Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing

Damian Szklarczyk, Doriano Fabbro, Stefan Knapp, 2011, Chemistry & biology.

Hot Spots in Tcf4 for the Interaction with β-Catenin*

Jean-Yves Trosset, Stefan Knapp, Udo Oppermann, 2003, Journal of Biological Chemistry.

The bromodomain interaction module

Stefan Knapp, Panagis Filippakopoulos, S. Knapp, 2012, FEBS letters.

Accurate calculation of the absolute free energy of binding for drug molecules

Michael J. Bodkin, Philip C. Biggin, Matteo Aldeghi, 2015, Chemical science.

Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B

Lewis R. Vidler, Stefan Knapp, Susanne Müller, 2015, Journal of medicinal chemistry.

Bromo-deaza-SAH: a potent and selective DOT1L inhibitor.

Matthieu Schapira, Wenyu Yu, Wolfram Tempel, 2013, Bioorganic & medicinal chemistry.

7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes

Doriano Fabbro, Stefan Knapp, Jörg Trappe, 2011, Journal of medicinal chemistry.

A chemical toolbox for the study of bromodomains and epigenetic signaling

Shili Duan, Mathieu Lupien, Stefan Knapp, 2018, bioRxiv.

The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins

Brian D. Marsden, Wen Hwa Lee, Stefan Knapp, 2007, Journal of Structural and Functional Genomics.

Bromodomains as therapeutic targets

Stefan Knapp, Panagis Filippakopoulos, Susanne Muller, 2011, Expert Reviews in Molecular Medicine.

Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib.

Alexander Pautsch, Stefan Knapp, Roman Fischer, 2016, ACS chemical biology.

Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk.

Christoph Bock, Giulio Superti-Furga, Johannes Zuber, 2016, Nature chemical biology.

Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.

Jules C Hancox, Stefan Knapp, Jennifer Batson, 2017, ACS chemical biology.

Critical Residues for Structure and Catalysis in Short-chain Dehydrogenases/Reductases*

Erik Nordling, Stefan Knapp, Udo Oppermann, 2002, The Journal of Biological Chemistry.

Crystal structure of the SOCS2–elongin C–elongin B complex defines a prototypical SOCS box ubiquitin ligase

Stefan Knapp, Aled M. Edwards, S. Knapp, 2006, Proceedings of the National Academy of Sciences of the United States of America.

High-throughput NMR-based screening with competition binding experiments.

Stefan Knapp, Marina Veronesi, Claudio Dalvit, 2002, Journal of the American Chemical Society.

Inhibition of BET Bromodomain Targets Genetically Diverse Glioblastoma

Reid C Thompson, Stefan Knapp, Susanne Muller, 2013, Clinical Cancer Research.

Architecture of nonspecific protein–DNA interactions in the Sso7d–DNA complex

Stefan Knapp, S. Knapp, R. Ladenstein, 1998, Nature Structural Biology.

Predictions of Ligand Selectivity from Absolute Binding Free Energy Calculations

Philip C Biggin, Matteo Aldeghi, Stefan Knapp, 2016, Journal of the American Chemical Society.

Structurally sophisticated octahedral metal complexes as highly selective protein kinase inhibitors.

Gernot Frenking, Ronen Marmorstein, Stefan Knapp, 2011, Journal of the American Chemical Society.

Defined PEG smears as an alternative approach to enhance the search for crystallization conditions and crystal-quality improvement in reduced screens

Stefan Knapp, Frank von Delft, S. Knapp, 2015, Acta crystallographica. Section D, Biological crystallography.

Structure of the CaMKIIδ/Calmodulin Complex Reveals the Molecular Mechanism of CaMKII Kinase Activation

Wen Hwa Lee, Stefan Knapp, Frank von Delft, 2010, PLoS biology.

PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers

Stefan Knapp, Kilian Huber, S. Knapp, 2010, Haematologica.

Structure and Regulation of the Human Nek2 Centrosomal Kinase*

Stefan Knapp, Andrew M Fry, Oleg Fedorov, 2007, Journal of Biological Chemistry.

Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans Progressiva*

Stefan Knapp, Frank von Delft, S. Knapp, 2012, The Journal of Biological Chemistry.

Doing more than just the structure-structural genomics in kinase drug discovery.

Stefan Knapp, Brian D Marsden, S. Knapp, 2008, Current opinion in chemical biology.

Small Molecule Kinase Inhibitors Provide Insight into Mps1 Cell Cycle Function

Taebo Sim, Stefan Knapp, Panagis Filippakopoulos, 2010, Nature chemical biology.

Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B

Stefan Knapp, Susanne Müller, Chun-Wa Chung, 2015, Journal of medicinal chemistry.

Insights for the development of specific kinase inhibitors by targeted structural genomics.

Stefan Knapp, Oleg Fedorov, S. Knapp, 2007, Drug discovery today.

NMR-Based screening with competition water-ligand observed via gradient spectroscopy experiments: detection of high-affinity ligands.

Stefan Knapp, Marina Veronesi, Claudio Dalvit, 2002, Journal of medicinal chemistry.

Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography

Julien Rossignol, Steven V. Ley, Stefan Knapp, 2014 .

Novel approaches for targeting kinases: allosteric inhibition, allosteric activation and pseudokinases.

Wolfgang Jahnke, Stefan Knapp, W. Jahnke, 2014, Future medicinal chemistry.