A. P. Gomes

发表

Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy

D. Sinclair, A. Rosenzweig, C. Palmeira, 2010, Aging.

Dibenzofuran-induced mitochondrial dysfunction: Interaction with ANT carrier.

C. Palmeira, A. Moreno, A. Rolo, 2013, Toxicology in vitro : an international journal published in association with BIBRA.

Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38

D. Sinclair, T. White, E. Chini, 2013, Diabetes.

Measuring PGC-1α and its acetylation status in mouse primary myotubes.

D. Sinclair, A. P. Gomes, 2015, Methods in molecular biology.

Regulation of mitochondrial biogenesis in metabolic syndrome.

C. Palmeira, A. Rolo, A. P. Gomes, 2011, Current drug targets.

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

Dudley Lamming, D. Sinclair, K. Howitz, 2013, Science.

SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function.

R. de Cabo, D. Sinclair, R. Coppari, 2012, Cell metabolism.

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

E. Mercken, D. Sinclair, N. Price, 2013, Cell.

Geroncogenesis: metabolic changes during aging as a driver of tumorigenesis.

David A Sinclair, D. Sinclair, Lindsay E. Wu, 2014, Cancer cell.

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

E. Mercken, R. de Cabo, K. Becker, 2014, Aging cell.

Metformin improves healthspan and lifespan in mice

E. Mercken, R. de Cabo, D. Ingram, 2013, Nature Communications.

CORRIGENDUM: SRT1720 improves survival and healthspan of obese mice

E. Mercken, R. de Cabo, M. Gorospe, 2013, Scientific Reports.

Uncovering the beginning of diabetes: the cellular redox status and oxidative stress as starting players in hyperglycemic damage

C. Palmeira, A. Rolo, J. Teodoro, 2013, Molecular and Cellular Biochemistry.

Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome. Diabetes 2013;62:1084–1093

D. Sinclair, T. White, E. Chini, 2014, Diabetes.

Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis.

D. Sinclair, C. Palmeira, B. Hubbard, 2012, Biochimica et biophysica acta.

Indirubin-3'-oxime prevents hepatic I/R damage by inhibiting GSK-3beta and mitochondrial permeability transition.

C. Palmeira, A. Rolo, A. Varela, 2010, Mitochondrion.

SIRT1 activator SRT3025 provides atheroprotection in ApoE/ mice by increasing hepatic LDL receptor

J. Auwerx, D. Sinclair, T. Lüscher, 2019 .

The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression

J. Auwerx, D. Sinclair, T. Lüscher, 2014, European heart journal.

Indirubin and NAD+ prevent mitochondrial ischaemia/reperfusion damage in fatty livers

C. Palmeira, A. Rolo, A. Varela, 2018, European journal of clinical investigation.

Adenosine receptors: regulatory players in the preservation of mitochondrial function induced by ischemic preconditioning of rat liver

R. Cunha, C. Palmeira, A. Rolo, 2017, Purinergic Signalling.

SRT1720 improves survival and healthspan of obese mice

E. Mercken, R. de Cabo, M. Gorospe, 2011, Scientific reports.

Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: a possible role for SirT3 activation.

Francisco M. Peixoto, C. Palmeira, A. Rolo, 2013, Mitochondrion.

Enhancement of brown fat thermogenesis using chenodeoxycholic acid in mice

P. Flachs, J. Kopecký, K. Bardova, 2014, International Journal of Obesity.

SRT1720 improves survival and healthspan of obese mice

E. Mercken, R. de Cabo, M. Gorospe, 2011, Scientific reports.

Hepatic and skeletal muscle mitochondrial toxicity of chitosan oligosaccharides of normal and diabetic rats

C. Palmeira, A. Rolo, A. Gomes, 2016, Toxicology mechanisms and methods.

Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism

D. Sinclair, B. Hubbard, Jun Li, 2013, Cell cycle.

Killing by Bactericidal Antibiotics Does Not Depend on Reactive Oxygen Species

D. Sinclair, K. Howitz, J. Moss, 2022 .

Uncovering the beginning of diabetes: the cellular redox status and oxidative stress as starting players in hyperglycemic damage

C. Palmeira, A. Rolo, J. Teodoro, 2013, Molecular and Cellular Biochemistry.

Indirubin-3'-oxime impairs mitochondrial oxidative phosphorylation and prevents mitochondrial permeability transition induction.

C. Palmeira, A. Rolo, A. Varela, 2008, Toxicology and applied pharmacology.

Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance

D. Sinclair, T. Osborne, J. Ayala, 2017, Molecular metabolism.

Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: a possible role for SirT3 activation.

C. Palmeira, A. Rolo, J. Teodoro, 2013, Mitochondrion.

Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome. Diabetes 2013;62:1084–1093

D. Sinclair, T. White, E. Chini, 2014, Diabetes.

Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38

D. Sinclair, T. White, E. Chini, 2013, Diabetes.