Ya-min Tian

发表

The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases

R. Klose, P. Ratcliffe, Eleanor A. L. Bagg, 2011, EMBO reports.

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.

P. Ratcliffe, A. Conejo-García, C. Pugh, 2013, ACS chemical biology.

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

Frederik De Smet, Elisabetta Dejana, Sonja Loges, 2009, Cell.

Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia

Anton J. Enright, Martin Reczko, Carme Camps, 2014, Molecular Cancer.

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation

Michael I. Wilson, M. Mukherji, P. Jaakkola, 2001, Science.

Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family*

Christopher J Schofield, Neil J Oldham, S. Bhattacharya, 2002, The Journal of Biological Chemistry.

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

Michael I. Wilson, M. Mukherji, R. Barstead, 2001, Cell.

Oxygen-regulated and Transactivating Domains in Endothelial PAS Protein 1: Comparison with Hypoxia-inducible Factor-1α*

P. Ratcliffe, C. Pugh, J. O'rourke, 1999, The Journal of Biological Chemistry.

Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor*

A. Harris, P. Ratcliffe, H. Turley, 2004, Journal of Biological Chemistry.

Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer

P. Ratcliffe, R. Salama, D. Mole, 2015, PloS one.

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates

P. Ratcliffe, R. Fischer, W. Figg, 2019, eLife.

Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma.

Jan Lubinski, Salwati Shuib, C. Ricketts, 2009, Anticancer research.

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases

I. Landrieu, P. Ratcliffe, C. Domene, 2016, Nature Communications.

Differential Sensitivity of Hypoxia Inducible Factor Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors*

P. Ratcliffe, C. Pugh, B. Kessler, 2011, The Journal of Biological Chemistry.

Crosstalk between Autophagy and Apoptosis Modulates T-2 Toxin-Induced Toxicity in Liver Cells

Ya-Min Tian, Jingshu Chen, Naidong Wang, 2018 .

Leu‐574 of human HIF‐1α is a molecular determinant of prolyl hydroxylation

P. Ratcliffe, L. Huang, K. To, 2004 .

Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain

P. Ratcliffe, C. Pugh, C. Schofield, 2015, PloS one.

Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.

P. Ratcliffe, M. Mackeen, C. Schofield, 2013, Organic & biomolecular chemistry.

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity

Rachelle S. Singleton, P. Ratcliffe, B. Kessler, 2012, EMBO reports.

Genetic Analysis of the Role of the Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-inducible Factor (HIF) in Regulating HIF Transcriptional Target Genes*

C. Wykoff, P. Ratcliffe, H. Turley, 2004, Journal of Biological Chemistry.

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.

P. Ratcliffe, C. Pugh, C. Schofield, 2003, Bioorganic & medicinal chemistry letters.

A photoreactive small-molecule probe for 2-oxoglutarate oxygenases.

A. Mai, P. Ratcliffe, M. Mackeen, 2011, Chemistry & biology.

Peptide blockade of HIFα degradation modulates cellular metabolism and angiogenesis

Michael I. Wilson, P. Ratcliffe, K. Eckardt, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Novel Mechanism of Action for Hydralazine: Induction of Hypoxia-Inducible Factor-1 &agr;, Vascular Endothelial Growth Factor, and Angiogenesis by Inhibition of Prolyl Hydroxylases

A. Harris, H. Knowles, D. Mole, 2004, Circulation research.

The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin

J. Vandekerckhove, P. Ratcliffe, C. Pugh, 2004, FEBS letters.

Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors.

Michael A McDonough, Christopher J Schofield, P. Ratcliffe, 2012, Angewandte Chemie.

Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].

C. Wykoff, P. Ratcliffe, H. Turley, 2004, The Journal of biological chemistry.

Gene regulation by hypoxia

P. Ratcliffe, C. Pugh, P. Maxwell, 2000 .

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.

P. Ratcliffe, K. Eckardt, W. Bernhardt, 2006, Journal of molecular and cellular cardiology.

Determination and comparison of specific activity of the HIF‐prolyl hydroxylases

P. Ratcliffe, C. Pugh, D. Mole, 2004, FEBS letters.

Photoactivable peptides for identifying enzyme-substrate and protein-protein interactions.

A. Mai, P. Ratcliffe, B. Kessler, 2011, Chemical communications.

Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation.

P. Ratcliffe, D. Mole, Ya-Min Tian, 2006, The Biochemical journal.

Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation.

P. Ratcliffe, L. Huang, K. To, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Comparative analysis of N-terminal cysteine dioxygenation and prolyl-hydroxylation as oxygen sensing pathways in mammalian cells

P. Ratcliffe, Thomas P. Keeley, T. To, 2023, bioRxiv.