J. Wei

发表

Peroxisome proliferator‐activated receptor‐γ abrogates Smad‐dependent collagen stimulation by targeting the p300 transcriptional coactivator

Y. Barak, A. Ghosh, S. Bhattacharyya, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs

S. Bhattacharyya, J. Varga, S. Miller, 2022, Nature Communications.

The adipokine adiponectin has potent anti-fibrotic effects mediated via adenosine monophosphate-activated protein kinase: novel target for fibrosis therapy

S. Bhattacharyya, J. Varga, B. Ye, 2012, Arthritis Research & Therapy.

PPARγ Downregulation by TGFß in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis

M. Whitfield, Minghua Wu, A. Ghosh, 2010, PloS one.

Constitutive Smad signaling and Smad-dependent collagen gene expression in mouse embryonic fibroblasts lacking peroxisome proliferator-activated receptor-gamma.

Minghua Wu, A. Ghosh, J. Varga, 2008, Biochemical and biophysical research communications.

Myofibroblasts in Murine Cutaneous Fibrosis Originate From Adiponectin‐Positive Intradermal Progenitors

Tammara A. Wood, M. Whitfield, W. Tourtellotte, 2015, Arthritis & rheumatology.

The non-neuronal cyclin-dependent kinase 5 is a fibrotic mediator potentially implicated in systemic sclerosis and a novel therapeutic target

J. Varga, Wenxia Wang, Feng Fang, 2017, Oncotarget.

Regulation of Matrix Remodeling by Peroxisome Proliferator-Activated Receptor-γ: A Novel Link Between Metabolism and Fibrogenesis

S. Bhattacharyya, J. Varga, Manu Jain, 2012, The open rheumatology journal.

SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis

J. Arbiser, J. Varga, D. Kamp, 2016, Oncotarget.

Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation.

G. Mutlu, J. Varga, S. Russell, 2011, American journal of respiratory cell and molecular biology.

Fibrosis in systemic sclerosis: emerging concepts and implications for targeted therapy.

W. Tourtellotte, S. Bhattacharyya, J. Varga, 2011, Autoimmunity reviews.

The JAK/STAT pathway is activated in systemic sclerosis and is effectively targeted by tofacitinib

S. Bhattacharyya, J. Varga, A. Yeldandi, 2019, Journal of scleroderma and related disorders.

Targeting CD38-dependent NAD+ metabolism to mitigate multiple organ fibrosis

S. Bhattacharyya, J. Varga, S. Miller, 2020, iScience.

Integration of transcriptome and proteome profiles in placenta accreta reveals trophoblast over-migration as the underlying pathogenesis

Caixia Liu, Na Li, Tian Yang, 2021, Clinical Proteomics.

Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells.

R. Atit, M. Whitfield, J. Varga, 2012, Arthritis and rheumatism.

Peroxisome proliferator-activated receptor γ: innate protection from excessive fibrogenesis and potential therapeutic target in systemic sclerosis

Swati Bhattacharyya, John Varga, S. Bhattacharyya, 2010, Current opinion in rheumatology.

Toll‐like Receptor 9 Signaling Is Augmented in Systemic Sclerosis and Elicits Transforming Growth Factor β–Dependent Fibroblast Activation

W. Tourtellotte, S. Bhattacharyya, J. Varga, 2016, Arthritis & rheumatology.

A Synthetic TLR3 Ligand Mitigates Profibrotic Fibroblast Responses by Inducing Autocrine IFN Signaling

S. Bhattacharyya, J. Varga, Xiaoyong Sun, 2013, The Journal of Immunology.

Mutation in LEMD3 (Man1) Associated with Osteopoikilosis and Late-Onset Generalized Morphea: A New Buschke-Ollendorf Syndrome Variant

J. Varga, P. Ferguson, A. Laumann, 2016, Case reports in dermatological medicine.

The Transcriptional Cofactor Nab2 Is Induced by TGF-β and Suppresses Fibroblast Activation: Physiological Roles and Impaired Expression in Scleroderma

J. Milbrandt, S. Bhattacharyya, J. Varga, 2009, PloS one.

The Histone Deacetylase Sirtuin 1 Is Reduced in Systemic Sclerosis and Abrogates Fibrotic Responses by Targeting Transforming Growth Factor β Signaling

J. Varga, Jiucun Wang, M. Hinchcliff, 2015, Arthritis & rheumatology.

Autocrine IFN Signaling Inducing Profibrotic Fibroblast Responses by A Synthetic TLR3 Ligand Mitigates

S. Bhattacharyya, J. Varga, Feng Fang, 2013 .

Identification of Optimal Mouse Models of Systemic Sclerosis by Interspecies Comparative Genomics

Jaclyn N. Taroni, M. Whitfield, M. Greenblatt, 2016, Arthritis & rheumatology.

Myofibroblasts in Cutaneous Fibrosis Originate from Adiponectin-Positive Intradermal Progenitors Running Head: Adipocytemyofibroblast transition (AMT) in skin fibrosis

Tammara A. Wood, M. Whitfield, W. Tourtellotte, 2014 .

Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma?

O. MacDougald, R. Lafyatis, J. Varga, 2011, Arthritis and rheumatism.

A synthetic PPAR-γ agonist triterpenoid ameliorates experimental fibrosis: PPAR-γ-independent suppression of fibrotic responses

J. Varga, Hongyan Zhu, M. Hinchcliff, 2013, Annals of the rheumatic diseases.

The early growth response gene Egr2 (Alias Krox20) is a novel transcriptional target of transforming growth factor-β that is up-regulated in systemic sclerosis and mediates profibrotic responses.

Swati Bhattacharyya, John Varga, Minghua Wu, 2011, The American journal of pathology.

Fibrosis in systemic sclerosis: common and unique pathobiology

W. Tourtellotte, S. Bhattacharyya, J. Varga, 2012, Fibrogenesis & tissue repair.

Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities

S. Bhattacharyya, J. Varga, J. Wei, 2012, Nature Reviews Rheumatology.

Adiponectin is an endogenous anti-fibrotic mediator and therapeutic target

W. Tourtellotte, L. Otvos, J. Varga, 2017, Scientific Reports.

Levels of adiponectin, a marker for PPAR-gamma activity, correlate with skin fibrosis in systemic sclerosis: potential utility as biomarker?

M. Whitfield, J. Varga, M. Hinchcliff, 2012, Arthritis Research & Therapy.