Y. Xie

发表

Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease

Lisa M Anderson, L. Raymond, M. Hayden, 2018, Science Translational Medicine.

Inflammatory Response Associated with Axonal Injury to Spinal Motoneurons in Newborn Rats

Wutian Wu, K. So, Q. Yuan, 2003, Developmental Neuroscience.

Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression.

D. Ehrnhoefer, M. Hayden, B. Leavitt, 2010, Human molecular genetics.

Altered adult hippocampal neurogenesis in the YAC128 transgenic mouse model of Huntington disease

B. Christie, M. Hayden, M. Pouladi, 2011, Neurobiology of Disease.

Delayed implantation of a peripheral nerve graft reduces motoneuron survival but does not affect regeneration following spinal root avulsion in adult rats.

Wutian Wu, Yuanyun Xie, H. Gu, 2004, Journal of neurotrauma.

Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.

D. Ehrnhoefer, Bibiana K Y Wong, M. Hayden, 2012, Human molecular genetics.

Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin.

M. Hayden, M. Pouladi, R. Graham, 2008, Brain : a journal of neurology.

NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease

D. Ehrnhoefer, M. Hayden, M. Pouladi, 2012, Neurobiology of Disease.

Potential roles of Alzheimer precursor protein A4 and β‐amyloid in survival and function of aged spinal motor neurons after axonal injury

Wutian Wu, Z. Yao, Yuanyun Xie, 2003, Journal of neuroscience research.

Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression

M. Hayden, B. Leavitt, J. Collins, 2015, Scientific Reports.

Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease

M. Hayden, Janaki Veeraraghavan, A. Jonason, 2015, Neurobiology of Disease.

Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease

C. Calaminus, M. Hayden, K. Chuang, 2016, Human molecular genetics.

The Interaction of Aging and Cellular Stress Contributes to Pathogenesis in Mouse and Human Huntington Disease Neurons

M. Hayden, V. Mattis, N. Caron, 2020, Frontiers in Aging Neuroscience.

The interaction of aging and oxidative stress contributes to pathogenesis in mouse and human Huntington disease neurons

M. Hayden, V. Mattis, N. Caron, 2019, bioRxiv.

A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles

M. Hayden, M. Pouladi, X. Gu, 2017, Human molecular genetics.

An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes.

Lisa M Anderson, L. Raymond, M. Hayden, 2016, Human molecular genetics.

In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides.

S. Freier, M. Hayden, C. Bennett, 2014, Molecular therapy : the journal of the American Society of Gene Therapy.

A fully humanized transgenic mouse model of Huntington disease.

M. Hayden, J. Collins, M. Pouladi, 2013, Human molecular genetics.

Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice.

M. Hayden, S. Butland, L. Shihabuddin, 2012, Human molecular genetics.

Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease

M. Hayden, Ji-Joon Song, I. Seong, 2020, The Journal of Neuroscience.

Skin-Derived Precursors Generate Myelinating Schwann Cells That Promote Remyelination and Functional Recovery after Contusion Spinal Cord Injury

F. Miller, J. Biernaskie, W. Tetzlaff, 2007, The Journal of Neuroscience.

GDNF and BDNF alter the expression of neuronal NOS, c-Jun, and p75 and prevent motoneuron death following spinal root avulsion in adult rats.

R. Oppenheim, Wutian Wu, Yuanyun Xie, 2003, Journal of neurotrauma.

Cerebrospinal fluid mutant huntingtin is a biomarker for huntingtin lowering in the striatum of Huntington disease mice

Lisa M Anderson, M. Hayden, N. Caron, 2022, Neurobiology of Disease.

HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo

Lisa M Anderson, D. Ehrnhoefer, M. Hayden, 2018, Human molecular genetics.

Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease

M. Hayden, S. V. van Deventer, N. Caron, 2019, Nucleic acids research.

A04 Caspase 6 resistant mutant huntingtin does not rescue the toxic effects of caspase cleavable mutant huntingtin in vivo

M. Hayden, M. Pouladi, R. Graham, 2010, Journal of Neurology, Neurosurgery & Psychiatry.

Expression and Role of Low-Affinity Nerve Growth Factor Receptor (p75) in Spinal Motor Neurons of Aged Rats following Axonal Injury

Wutian Wu, Z. Yao, Yuanyun Xie, 2003, Developmental Neuroscience.

Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin.

M. Hayden, M. Pouladi, R. Graham, 2008, Brain : a journal of neurology.

Altered adult hippocampal neurogenesis in the YAC128 transgenic mouse model of Huntington disease

B. Christie, M. Hayden, M. Pouladi, 2011, Neurobiology of Disease.

Transient sublethal hypoxia in neonatal rats causes reduced dendritic spines, aberrant synaptic plasticity, and impairments in memory

M. O'Connor, H. Man, Xiaoming Xin, 2020, Journal of neuroscience research.