T. Louie

A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6.

S. Ely, S. Chen‐Kiang, P. Toogood, 2006, Cancer research.

Prolonged early G(1) arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4.

W. Hahn, L. Staudt, A. Shaffer, 2012, Blood.

A Novel Orally Active Small Molecule Potently Induces G1 Arrest in Primary Myeloma Cells and Prevents Tumor Growth by Specific Inhibition of Cdk4/6.

S. Ely, S. Chen‐Kiang, P. Toogood, 2006 .

Targeting Cdk4/6 in combination therapy of chemoresistant multiple myeloma

S. Ely, S. Chen‐Kiang, M. Moore, 2008 .

Targeting Cdk4/6 in Combination Therapy Overcomes Proteasome Inhibitor Resistance in Multiple Myeloma through Synergistic Mitochondria Depolarization.

S. Chen‐Kiang, P. Toogood, M. Palladino, 2007 .