Jian‐Xiong Chen

发表

Emerging Role of Pericytes and Their Secretome in the Heart

Shai-hong Zhu, H. Zeng, Aubrey C Cantrell, 2021, Cells.

Apelin-13 increases myocardial progenitor cells and improves repair postmyocardial infarction.

Lanfang Li, H. Zeng, Jian-Xiong Chen, 2012, American journal of physiology. Heart and circulatory physiology.

Notch3 deficiency impairs coronary microvascular maturation and reduces cardiac recovery after myocardial ischemia.

H. Zeng, X. He, Xue-Jiao Xie, 2017, International journal of cardiology.

Emerging role of SIRT3 in endothelial metabolism, angiogenesis, and cardiovascular disease

H. Zeng, Xiaochen He, Jian‐Xiong Chen, 2018, Journal of cellular physiology.

Inhibition of prolyl hydroxylases alters cell metabolism and reverses pre-existing diastolic dysfunction in mice.

R. Roman, H. Zeng, X. He, 2018, International journal of cardiology.

Microvascular Rarefaction and Heart Failure With Preserved Ejection Fraction

H. Zeng, Jian‐Xiong Chen, 2019, Front. Cardiovasc. Med..

Caveolae and Caveolin-1 Integrate Reverse Cholesterol Transport and Inflammation in Atherosclerosis

Xi-Long Zheng, Neng Zhu, Chan Liu, 2016, International journal of molecular sciences.

HSP90 and Akt modulate Ang-1-induced angiogenesis via NO in coronary artery endothelium.

B. Meyrick, B. Christman, Jian-Xiong Chen, 2004, Journal of applied physiology.

Ablation of endothelial prolyl hydroxylase domain protein‐2 promotes renal vascular remodelling and fibrosis in mice

H. Zeng, X. He, Q. Tuo, 2017, Journal of cellular and molecular medicine.

Ferritinophagy activation and sideroflexin1-dependent mitochondria iron overload is involved in apelin-13-induced cardiomyocytes hypertrophy.

Lanfang Li, Linxi Chen, Jiuchang Zhong, 2019, Free radical biology & medicine.

Dual functional roles of Tie-2/angiopoietin in TNF-α-mediated angiogenesis

L. Debusk, P. C. Lin, Jian-Xiong Chen, 2004 .

Dual functional roles of Tie-2/angiopoietin in TNF-alpha-mediated angiogenesis.

L. Debusk, P. C. Lin, Jian-Xiong Chen, 2004, American journal of physiology. Heart and circulatory physiology.

IL-12α deficiency attenuates pressure overload-induced cardiac inflammation, hypertrophy, dysfunction, and heart failure progression

R. Xu, Umesh Bhattarai, Xiaochen He, 2023, Frontiers in Immunology.

NADPH oxidase modulates myocardial Akt, ERK1/2 activation, and angiogenesis after hypoxia-reoxygenation.

J. Aschner, B. Meyrick, H. Zeng, 2007, American journal of physiology. Heart and circulatory physiology.

SIRT3 Deficiency Sensitizes Angiotensin-II-Induced Renal Fibrosis

H. Zeng, Jian-Xiong Chen, Xiaochen He, 2020, Cells.

Ablation of SIRT3 causes coronary microvascular dysfunction and impairs cardiac recovery post myocardial ischemia.

H. Zeng, Xiaochen He, Jian‐Xiong Chen, 2016, International journal of cardiology.

Endothelial prolyl hydroxylase 2 is necessary for Angiotensin II-mediated renal fibrosis and injury.

H. Zeng, X. He, Jian-Xiong Chen, 2020, American journal of physiology. Renal physiology.

Apelin gene therapy increases myocardial vascular density and ameliorates diabetic cardiomyopathy via upregulation of sirtuin 3.

Lanfang Li, H. Zeng, X. He, 2014, American journal of physiology. Heart and circulatory physiology.

Ang-1 Gene Therapy Inhibits Hypoxia-Inducible Factor-1α (HIF-1α)-Prolyl-4-Hydroxylase-2, Stabilizes HIF-1α Expression, and Normalizes Immature Vasculature in db/db Mice

Jian-Xiong Chen, Amanda M Stinnett, Jian‐Xiong Chen, 2008, Diabetes.

Hypoxia increases Hsp90 binding to eNOS via PI3K-Akt in porcine coronary artery endothelium

B. Meyrick, Jian-Xiong Chen, Jian‐Xiong Chen, 2004, Laboratory Investigation.

Sirtuin 3 Alleviates Diabetic Cardiomyopathy by Regulating TIGAR and Cardiomyocyte Metabolism

Lanfang Li, H. Zeng, Xiaochen He, 2021, Journal of the American Heart Association.

Glutathione mediates LPS‐stimulated COX‐2 expression via early transient p42/44 MAPK activation

B. Meyrick, B. Christman, L. Berry, 2003, Journal of cellular physiology.

Loss of Sirt3 Limits Bone Marrow Cell-Mediated Angiogenesis and Cardiac Repair in Post-Myocardial Infarction

Lanfang Li, H. Zeng, Jian-Xiong Chen, 2014, PloS one.

Myocardial Injection of Apelin-Overexpressing Bone Marrow Cells Improves Cardiac Repair via Upregulation of Sirt3 after Myocardial Infarction

Lanfang Li, H. Zeng, X. He, 2013, PloS one.

Overexpression of Angiopoietin-1 Increases CD133+/c-kit+ Cells and Reduces Myocardial Apoptosis in db/db Mouse Infarcted Hearts

Lanfang Li, H. Zeng, Jian-Xiong Chen, 2012, PloS one.

P53 Acetylation Exerts Critical Roles In Pressure Overload Induced Coronary Microvascular Dysfunction and Heart Failure

W. Gu, H. Zeng, Xiaochen He, 2023, bioRxiv.

Knockout of TIGAR enhances myocardial phosphofructokinase activity and preserves diastolic function in heart failure

H. Zeng, Jian-Xiong Chen, Xiaochen He, 2022, Journal of cellular physiology.

Regulatory role of TIGAR on endothelial metabolism and angiogenesis

H. Zeng, Jian-Xiong Chen, Xiaochen He, 2021, Journal of cellular physiology.

Curcumin enhances vascular contractility via induction of myocardin in mouse smooth muscle cells

Xiao-yong Lei, Q. Tuo, D. Liao, 2017, Acta Pharmacologica Sinica.

PINK1/Parkin‐mediated mitophagy promotes apelin‐13‐induced vascular smooth muscle cell proliferation by AMPKα and exacerbates atherosclerotic lesions

Lanfang Li, Linxi Chen, Jiuchang Zhong, 2018, Journal of cellular physiology.

Critical role of angiopoietins/Tie-2 in hyperglycemic exacerbation of myocardial infarction and impaired angiogenesis.

J. Aschner, H. Zeng, Q. Tuo, 2008, American journal of physiology. Heart and circulatory physiology.

SIRTUIN 3, ENDOTHELIAL METABOLIC REPROGRAMMING AND HEART FAILURE WITH PRESERVED EJECTION FRACTION.

H. Zeng, Jian-Xiong Chen, Jian‐Xiong Chen, 2019, Journal of cardiovascular pharmacology.

A Sex-Specific Role of Endothelial Sirtuin 3 on Blood Pressure and Diastolic Dysfunction in Female Mice

H. Zeng, Jian-Xiong Chen, Xiaochen He, 2020, International journal of molecular sciences.

Nitric oxide donors regulate nitric oxide synthase in bovine pulmonary artery endothelium

B. Meyrick, L. Berry, M. Tanner, 2001, Journal of cellular physiology.

Apelin Gene Therapy Increases Autophagy via Activation of Sirtuin 3 in Diabetic Heart

H. Zeng, Q. Tuo, X. Hou, 2015, Diabetes research.

High density lipoprotein 3 inhibits oxidized low density lipoprotein-induced apoptosis via promoting cholesterol efflux in RAW264.7 cells

Xiao-yong Lei, D. Liao, W. Yin, 2006, Acta Pharmacologica Sinica.

High density lipoprotein 3 inhibits oxidized low density lipoprotein-induced apoptosis via promoting cholesterol efflux in RAW 264 . 7 cells 1

Xiao-yong Lei, D. Liao, W. Yin, 2006 .

Endothelial specific SIRT3 deletion impairs glycolysis and angiogenesis and causes diastolic dysfunction.

J. Aschner, R. Roman, H. Zeng, 2017, Journal of molecular and cellular cardiology.

Endothelial Sirtuin 3 Dictates Glucose Transport to Cardiomyocyte and Sensitizes Pressure Overload‐Induced Heart Failure

H. Zeng, Jian-Xiong Chen, Xiaochen He, 2020, Journal of the American Heart Association.

Loss of prolyl hydroxylase domain protein 2 in vascular endothelium increases pericyte coverage and promotes pulmonary arterial remodeling

J. Aschner, R. Roman, H. Zeng, 2016, Oncotarget.

LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2α/Notch3 pathways

H. Zeng, X. He, Q. Tuo, 2016, Scientific Reports.

Angiopoietin-1-induced angiogenesis is modulated by endothelial NADPH oxidase.

B. Meyrick, T. Blackwell, H. Zeng, 2006, American journal of physiology. Heart and circulatory physiology.

Regulatory Role of Endothelial PHD2 in the Hepatic Steatosis

H. Zeng, Jian-Xiong Chen, Liying Zhou, 2018, Cellular Physiology and Biochemistry.

Oleate inhibits hepatic autophagy through p38 mitogen-activated protein kinase (MAPK).

J. Ning, D. Liao, Jian-Xiong Chen, 2019, Biochemical and biophysical research communications.

Overexpression of angiopoietin-2 impairs myocardial angiogenesis and exacerbates cardiac fibrosis in the diabetic db/db mouse model.

J. Aschner, B. Meyrick, H. Zeng, 2012, American journal of physiology. Heart and circulatory physiology.

Sirtuin 3 is essential for hypertension‐induced cardiac fibrosis via mediating pericyte transition

H. Zeng, Jian-Xiong Chen, Bo Liu, 2020, Journal of Cellular and Molecular Medicine.

High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss

G. Booz, H. Zeng, X. He, 2015, Journal of cellular and molecular medicine.

Sirt3 is essential for apelin-induced angiogenesis in post-myocardial infarction of diabetes

H. Zeng, Xiaochen He, X. Hou, 2014, Journal of cellular and molecular medicine.

Conditional Knockout of Prolyl Hydroxylase Domain Protein 2 Attenuates High Fat-Diet-Induced Cardiac Dysfunction in Mice

H. Zeng, Jian-Xiong Chen, Jian‐Xiong Chen, 2014, PloS one.

Critical role of the NADPH oxidase subunit p47phox on vascular TLR expression and neointimal lesion formation in high-fat diet-induced obesity

Jian-Xiong Chen, Amanda M Stinnett, Jian‐Xiong Chen, 2008, Laboratory Investigation.

Isoprostanes as physiological mediators of transition to newborn life: novel mechanisms regulating patency of the term and preterm ductus arteriosus

J. Aschner, B. Paria, J. Slaughter, 2012, Pediatric Research.

Histone Acetyltransferase p300 Inhibitor Improves Coronary Flow Reserve in SIRT3 (Sirtuin 3) Knockout Mice

Shai-hong Zhu, H. Zeng, Jian-Xiong Chen, 2020, Journal of the American Heart Association.

High Glucose Activates Prolyl Hydroxylases and Disrupts HIF-α Signaling via the P53/TIGAR Pathway in Cardiomyocyte

Lanfang Li, H. Zeng, Aubrey C Cantrell, 2023, Cells.

Disruption of Ang-1/Tie-2 Signaling Contributes to the Impaired Myocardial Vascular Maturation and Angiogenesis in Type II Diabetic Mice

Jian-Xiong Chen, Amanda M Stinnett, Jian‐Xiong Chen, 2008, Arteriosclerosis, thrombosis, and vascular biology.

Cholesterol in LDL receptor recycling and degradation.

Hui-xian Yang, Q. Tuo, D. Liao, 2019, Clinica chimica acta; international journal of clinical chemistry.

IDOL, inducible degrader of low-density lipoprotein receptor, serves as a potential therapeutic target for dyslipidemia.

Min Zhang, Jian-xiong Chen, Min Zhang, 2016, Medical hypotheses.

SIRT3 Deficiency Enhances Ferroptosis and Promotes Cardiac Fibrosis via p53 Acetylation

H. Zeng, Aubrey C Cantrell, Han Su, 2023, Cells.

Cardiac pericyte is promising target for ischemic heart diseases: Role of Notch3.

Sean T. Chen, Y. Tao, Jian‐Xiong Chen, 2017, International journal of cardiology.

Probucol inhibits oxidized-low density lipoprotein-induced adhesion of monocytes to endothelial cells by reducing P-selectin synthesis in vitro.

D. Liao, Li-xin Li, L. Li, 1998, Endothelium : journal of endothelial cell research.

Inhibition of Protein Tyrosine Phosphatase Improves Angiogenesis via Enhancing Ang-1/Tie-2 Signaling in Diabetes

H. Zeng, Q. Tuo, D. Liao, 2012, Experimental diabetes research.

Angiopoietin-1 protects myocardial endothelial cell function blunted by angiopoietin-2 and high glucose condition

H. Zeng, Q. Tuo, D. Liao, 2011, Acta Pharmacologica Sinica.

TIGAR deficiency sensitizes angiotensin‐II‐induced renal fibrosis and glomerular injury

H. Zeng, Jian-Xiong Chen, Xiaochen He, 2022, Physiological reports.

Inhibition of NK1.1 signaling attenuates pressure overload-induced heart failure, and consequent pulmonary inflammation and remodeling

Michael E. Hall, H. Zeng, Umesh Bhattarai, 2023, Frontiers in immunology.

The Therapeutic Potential of Targeting Ferroptosis in the Treatment of Mitochondrial Cardiomyopathies and Heart Failure

H. Zeng, Aubrey C Cantrell, Jian‐Xiong Chen, 2023, Journal of cardiovascular pharmacology.

Heme Oxygenase, Ginkgo Biloba Extract and its Terpenoids Protect Myocytes Against Oxidative Injury

H. Zeng, Jian-Xiong Chen, C. Su, 2002 .

Endothelial specific prolyl hydroxylase domain-containing protein 2 deficiency attenuates aging-related obesity and exercise intolerance

H. Zeng, Xiaochen He, J. Clemmer, 2024, GeroScience.

TIGAR Deficiency Blunts Angiotensin-II-Induced Cardiac Hypertrophy in Mice

H. Zeng, Xiaochen He, Aubrey C Cantrell, 2024, International journal of molecular sciences.

Ferrostatin-1 specifically targets mitochondrial iron-sulfur clusters and aconitase to improve cardiac function in Sirtuin 3 cardiomyocyte knockout mice.

H. Zeng, Jian‐Xiong Chen, Ngoc Hoang, 2024, Journal of molecular and cellular cardiology.

Endothelial Cell-Specific Prolyl Hydroxylase-2 Deficiency Augments Angiotensin II-Induced Arterial Stiffness and Cardiac Pericyte Recruitment in Mice.

H. Zeng, Bo Liu, Han Su, 2024, Journal of the American Heart Association.