Iván Díaz

Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons

Robert H. Brown, D. A. Bosco, F. González-Nilo, 2022, Neuron.

Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice

M. Montecino, E. Ampuero, Nur Jury, 2020, Clinical Epigenetics.

BET bromodomain inhibitors PFI-1 and JQ1 are identified in an epigenetic compound screen to enhance C9ORF72 gene expression and shown to ameliorate C9ORF72-associated pathological and behavioral abnormalities in a C9ALS/FTD model

Robert H. Brown, M. Montecino, Nur Jury, 2021, Clinical epigenetics.

Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice

M. Montecino, E. Ampuero, Nur Jury, 2020, Clinical Epigenetics.

Mature iPSC-derived astrocytes of an ALS/FTD patient carrying the TDP43 A90V mutation display a mild reactive state and release polyP toxic to motoneurons

M. Montecino, E. Ampuero, Rodrigo Aguilar, 2023, Frontiers in cell and developmental biology.