Claire L McWhirter

发表

Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance

A. Tutt, A. Nussenzweig, S. Boulton, 2021, Nature Communications.

Overcoming mTOR Resistance Mutations with a New Generation mTOR Inhibitor

Elisa de Stanchina, Neal Rosen, Kevan M. Shokat, 2016, Nature.

Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S-Mediated Resistance.

Paul D. Smith, Michal Bista, D. Hargreaves, 2021, Journal of medicinal chemistry.

Kinetic mechanisms of covalent inhibition

Claire L McWhirter, 2021 .

Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.

V. Grinkevich, A. Turnbull, N. Holliday, 2022, Journal of medicinal chemistry.

Cellular Active N-Hydroxyurea FEN1 Inhibitors Block Substrate Entry to the Active Site

J. Debreczeni, J. Nissink, L. Finger, 2016, Nature chemical biology.

Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma.

Nichola L. Davies, A. Ferguson, L. Drew, 2017, Journal of medicinal chemistry.

Development of a High-Throughput Fluorescence Polarization DNA Cleavage Assay for the Identification of FEN1 Inhibitors

Michael Tonge, H. Plant, S. Durant, 2013, Journal of biomolecular screening.

Identification and optimisation of 7-azaindole PAK1 inhibitors with improved potency and kinase selectivity

E. Hennessy, C. Chuaqui, A. Ferguson, 2014 .

Mechanistic study of protein phosphatase-1 (PP1), a catalytically promiscuous enzyme.

A. Hengge, Nicholas H Williams, Q. I. Sheikh, 2008, Journal of the American Chemical Society.

Abstract 2147: Overcoming mTOR resistance mutations with a new generation mTOR inhibitor

M. Berger, K. Shokat, N. Rosen, 2016 .