Rachel Juneau

Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition.

Frédérick A. Mallette, C. Yohn, C. Beauséjour, 2021, Cell metabolism.

Myeloid-resident neuropilin-1 influences brown adipose tissue in obesity

T. Alquier, S. Crespo-Garcia, P. Sapieha, 2021, Scientific Reports.

Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy

Frédérick A. Mallette, G. Andelfinger, J. Côté, 2020, Science.

Early-life peripheral infections reprogram retinal microglia and aggravate neovascular age-related macular degeneration in later life

S. Crespo-Garcia, P. Sapieha, Jean-Sébastien Joyal, 2023, The Journal of clinical investigation.

Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation

T. Langmann, C. Des Rosiers, C. Daneault, 2023, Science.

miR-106b suppresses pathological retinal angiogenesis

V. de Guire, S. Crespo-Garcia, P. Sapieha, 2020, Aging.

HIF1α-dependent hypoxia response in myeloid cells requires IRE1α

Frédérick A. Mallette, S. Crespo-Garcia, E. Affar, 2023, Journal of Neuroinflammation.

Obesity triggers tumoral senescence and renders poorly immunogenic malignancies amenable to senolysis

Frédérick A. Mallette, B. Larrivée, S. Crespo-Garcia, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results.

Pamela R. Tsuruda, P. Sapieha, G. Cagnone, 2024, Nature medicine.