T. J. Buchholz

发表

Clinical Activity of CC-90009, a Cereblon E3 Ligase Modulator and First-in-Class GSPT1 Degrader, As a Single Agent in Patients with Relapsed or Refractory Acute Myeloid Leukemia (R/R AML): First Results from a Phase I Dose-Finding Study

J. Esteve, P. Vyas, M. Minden, 2019, Blood.

Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits

J. Weissman, P. Walter, Chunaram Choudhary, 2015, eLife.

Avadomide monotherapy in relapsed/refractory DLBCL: Safety, efficacy, and a predictive gene classifier.

G. Salles, A. Salar, J. Sancho, 2020, Blood.

Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome.

S. Demo, M. Aujay, M. Bennett, 2007, Cancer research.

The immunoproteasome β5i subunit is a key contributor to ictogenesis in a rat model of chronic epilepsy

P. Kloetzel, U. Heinemann, A. Vezzani, 2015, Brain, Behavior, and Immunity.

Immunoproteasome functions explained by divergence in cleavage specificity and regulation

A. Sali, C. Craik, Peter Cimermancic, 2017, eLife.

Paradoxical role of the 19 S proteasomal regulator 1 Paradoxical resistance of multiple myeloma to proteasome inhibitors 1 by decreased levels of 19 S proteasomal subunits 2 3

Jonathan, Choudhary, O. Simakova, 2015 .

Biochemical and structural characterization of germicidin synthase: analysis of a type III polyketide synthase that employs acyl-ACP as a starter unit donor.

Janet L. Smith, G. Chlipala, D. Sherman, 2012, Journal of the American Chemical Society.

In vivo and in vitro trans-acylation by BryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont.

David H Sherman, Kristina Håkansson, Christopher M Thomas, 2008, Chemistry & biology.

Protein-Protein Interactions During Acyl Transfer In Polyketide Biosynthesis.

T. Buchholz, T. J. Buchholz, 2010 .

Substrate Profile Analysis and ACP‐Mediated Acyl Transfer in Streptomyces coelicolor Type III Polyketide Synthases

J. Dordick, D. Sherman, W. Seufert, 2007, Chembiochem : a European journal of chemical biology.

Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains.

David H Sherman, K. Reynolds, Janet L. Smith, 2009, ACS chemical biology.

Modular Polyketide Synthases

D. Sherman, J. D. Kittendorf, Jeffrey D. Kittendorf, 2012 .

Polyketide Biosynthesis: Modular Polyketide Synthases

D. Sherman, J. D. Kittendorf, Jeffrey D. Kittendorf, 2008 .

Polyketide β-branching in bryostatin biosynthesis: identification of surrogate acetyl-ACP donors for BryR, an HMG-ACP synthase.

D. Sherman, K. Håkansson, C. Rath, 2010, Chemistry & biology.

Interrogating the molecular basis for multiple macrolactone ring formation by the pikromycin polyketide synthase.

D. Sherman, W. Seufert, J. D. Kittendorf, 2007, Chemistry & biology.

Clinical Activity of CC-99282, a Novel, Oral Small Molecule Cereblon E3 Ligase Modulator (CELMoD) Agent, in Patients (Pts) with Relapsed or Refractory Non-Hodgkin Lymphoma (R/R NHL) - First Results from a Phase 1, Open-Label Study

S. Ferrari, S. Carrancio, J. Kuruvilla, 2021, Blood.

Development of a capillary electrophoresis platform for identifying inhibitors of protein-protein interactions.

R. Kennedy, J. Gestwicki, J. N. Rauch, 2013, Analytical chemistry.

Parallel synthesis of glycomimetic libraries: targeting a C-type lectin.

L. Kiessling, W. Thomas, D. Mann, 2003, Organic letters.

In vivo and in vitro trans-acylation by BryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont.

Christopher M Thomas, D. Sherman, K. Håkansson, 2008, Chemistry & biology.