Jillian Friedrich

发表

ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism

Maxime W. C. Rousseaux, Elizabeth P. Lackey, H. Zoghbi, 2018, Neuron.

Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model

H. Zoghbi, H. Orr, M. Walters, 2018, Neurobiology of Disease.

Antisense Oligonucleotide Therapeutic Approach for Suppression of Ataxin-1 Expression: A Safety Assessment

H. Orr, C. Henzler, Tracy A. Cole, 2020, Molecular therapy. Nucleic acids.

Antisense oligonucleotide-mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles.

H. Zoghbi, H. Orr, G. Öz, 2018, JCI insight.

Cholecystokinin 1 receptor activation restores normal mTORC1 signaling and is protective to Purkinje cells of SCA mice

S. Pulst, H. Orr, K. Figueroa, 2021, Cell reports.

Cholecystokinin 1 Receptor (Cck1R) Normalizes mTORC1 signaling and is Protective to Purkinje cells of SCA Mice

S. Pulst, H. Orr, K. Figueroa, 2021, bioRxiv.

Cholecystokinin 1 Receptor (Cck1R) Activates mTORC1 Signaling and is Protective to Purkinje Cells in SCA Mice

H. Orr, C. Henzler, Tyler Tschumperlin, 2021, SSRN Electronic Journal.

Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model

H. Zoghbi, H. Orr, M. Walters, 2018, Neurobiology of Disease.

Antisense oligonucleotide-mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles.

H. Zoghbi, H. Orr, G. Öz, 2018, JCI insight.