Clay W Scott

发表

Figure 5: [Definition of beat parameters. RTCA...].

Sarah D. Lamore, Clay W Scott, Matthew F. Peters, 2015 .

Table 1: [Definition of beat parameters. RTCA...].

Sarah D. Lamore, Clay W Scott, Matthew F. Peters, 2015 .

Label-free whole-cell assays: expanding the scope of GPCR screening.

Clay W Scott, M. F. Peters, C. Scott, 2010, Drug discovery today.

Comparing label-free biosensors for pharmacological screening with cell-based functional assays.

Clay W Scott, Matthew F Peters, François Vaillancourt, 2010, Assay and drug development technologies.

Development of a plate-based optical biosensor fragment screening methodology to identify phosphodiesterase 10A inhibitors.

Patrik Johansson, Rob Horsefield, Clay W Scott, 2013, Journal of medicinal chemistry.

Evaluation of Cellular Dielectric Spectroscopy, a Whole-Cell, Label-Free Technology for Drug Discovery on Gi-Coupled GPCRs

Clay W Scott, M. F. Peters, Jianwei Liu, 2007, Journal of biomolecular screening.

Human Stem Cell-Derived Cardiomyocytes in Cellular Impedance Assays: Bringing Cardiotoxicity Screening to the Front Line

Clay W Scott, Matthew F. Peters, Liang Guo, 2014, Cardiovascular Toxicology.

Evaluating Cellular Impedance Assays for Detection of GPCR Pleiotropic Signaling and Functional Selectivity

Clay W Scott, M. F. Peters, C. Scott, 2009, Journal of biomolecular screening.

Human induced pluripotent stem cells and their use in drug discovery for toxicity testing.

Clay W Scott, Y. Dragan, M. F. Peters, 2013, Toxicology letters.

Cellular impedance assays for predictive preclinical drug screening of kinase inhibitor cardiovascular toxicity.

Clay W Scott, Y. Dragan, M. F. Peters, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

A homogeneous in vitro functional assay for estrogen receptors: coactivator recruitment.

Clay W Scott, C. Scott, K. S. Knappenberger, 2003, Molecular endocrinology.

A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models

Clay W Scott, Ronald S. Reiserer, Clayton M. Britt, 2022, PLoS biology.

Biological Regulation by Protein Phosphorylation

Clay W Scott, R. Bhat, C. Scott, 2006 .

Mechanism of inhibition of fatty acid amide hydrolase by sulfonamide-containing benzothiazoles: long residence time derived from increased kinetic barrier and not exclusively from thermodynamic potency.

Clay W Scott, C. Scott, G. Tian, 2011, Biochemistry.

Human 3D Gastrointestinal Microtissue Barrier Function As a Predictor of Drug-Induced Diarrhea

Clay W Scott, M. F. Peters, T. Landry, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

Toward β-Secretase-1 Inhibitors with Improved Isoform Selectivity.

Clay W Scott, R. Bürli, J. Holenz, 2018, Journal of medicinal chemistry.

Deconvoluting Kinase Inhibitor Induced Cardiotoxicity

Godfrey L. Smith, Clay W Scott, Jonna C. Stålring, 2017, Toxicological sciences : an official journal of the Society of Toxicology.

Novel Small Molecule Inhibitors of Caspase-3 Block Cellular and Biochemical Features of Apoptosis

Clay W Scott, R. Bhat, C. Scott, 2003, Journal of Pharmacology and Experimental Therapeutics.

An impedance-based cellular assay using human iPSC-derived cardiomyocytes to quantify modulators of cardiac contractility.

Clay W Scott, M. F. Peters, Y. Abassi, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Microplate gel-filtration method for radioligand-binding assays.

Clay W Scott, A. Zacco, C. Scott, 2002, Analytical biochemistry.

Mechanism of γ-secretase cleavage activation: Is γ-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?

Clay W Scott, B. Greenberg, C. Scott, 2004 .

Developing in vitro assays to transform gastrointestinal safety assessment: potential for microphysiological systems.

Clay W Scott, K. Kolaja, M. F. Peters, 2020, Lab on a chip.

Mechanism of gamma-secretase cleavage activation: is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?

Clay W Scott, B. Greenberg, C. Scott, 2004, Biochemistry.

Interactions between GSK3β and caspase signalling pathways during NGF deprivation induced cell death

Clay W Scott, R. Bhat, Chi-Ming Lee, 2002 .

2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity.

Clay W Scott, Magnus J. Johansson, Jennifer R. Krumrine, 2011, Bioorganic & medicinal chemistry letters.

C3 activation is inhibited by analogs of compstatin but not by serine protease inhibitors or peptidyl alpha-ketoheterocycles.

Clay W Scott, C. W. Scott, P. Edwards, 2000, Immunopharmacology.

Fragment-assisted hit investigation involving integrated HTS and fragment screening: Application to the identification of phosphodiesterase 10A (PDE10A) inhibitors.

Clay W Scott, S. Geschwindner, N. Dekker, 2016, Bioorganic & medicinal chemistry letters.

Biochemical characterization and in vitro activity of AZ513, a noncovalent, reversible, and noncompetitive inhibitor of fatty acid amide hydrolase.

Clay W Scott, Xiao Hong Yu, P. Edwards, 2011, European journal of pharmacology.

Comparing label-free biosensors for pharmacological screening with cell-based functional assays.

Clay W Scott, M. F. Peters, M. Valiquette, 2010, Assay and drug development technologies.

Human Stem Cell-Derived Cardiomyocytes in Cellular Impedance Assays: Bringing Cardiotoxicity Screening to the Front Line

Clay W Scott, K. Kolaja, M. F. Peters, 2015, Cardiovascular Toxicology.

Cardiomyocyte Impedance Assays

Clay W Scott, C. Scott, Sarah D. Lamore, 2015 .

Evaluation of cellular impedance measures of cardiomyocyte cultures for drug screening applications.

Clay W Scott, Y. Dragan, M. F. Peters, 2012, Assay and drug development technologies.

A medium-throughput functional assay of KCNQ2 potassium channels using rubidium efflux and atomic absorption spectrometry.

Clay W Scott, D. Crankshaw, S. Trivedi, 2003, Analytical biochemistry.

Human ileal organoid model recapitulates clinical incidence of diarrhea associated with small molecule drugs.

Clay W Scott, K. Kolaja, M. F. Peters, 2020, Toxicology in vitro : an international journal published in association with BIBRA.

Parkin suppresses wild-type α-synuclein-induced toxicity in SHSY-5Y cells

Clay W Scott, J. Arriza, C. Scott, 2003 .

Development of a plate-based optical biosensor fragment screening methodology to identify phosphodiesterase 10A inhibitors.

Clay W Scott, S. Geschwindner, R. Horsefield, 2013, Journal of medicinal chemistry.

Discovery of spirofused piperazine and diazepane amides as selective histamine-3 antagonists with in vivo efficacy in a mouse model of cognition.

Clay W Scott, D. Labrecque, P. Bernstein, 2014, Journal of medicinal chemistry.