Jonathan D. Powell

Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug

Liang Zhao, T. Seiwert, A. Pal, 2022, Science advances.

Recombinant BCG overexpressing STING agonist elicits trained immunity and improved antitumor efficacy in non-muscle invasive bladder cancer

Liang Zhao, W. Bishai, D. Pardoll, 2020 .

Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis

Liang Zhao, W. Bishai, R. Leone, 2023, bioRxiv.

mTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis

M. Horton, A. Scott, W. Mitzner, 2017, Nature Communications.

Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis

W. Bishai, R. Leone, B. Slusher, 2023, Nature communications.

Metabolic Reprogramming of Tumor-Associated Macrophages Using Glutamine Antagonist JHU083 Drives Tumor Immunity in Myeloid-Rich Prostate and Bladder Cancers

R. Leone, Jelani C. Zarif, B. Slusher, 2024, Cancer immunology research.

GOT1 constrains T_H17 cell differentiation, while promoting iT_reg cell differentiation

Liang Zhao, A. Tam, Chirag H. Patel, 2023, Nature.