K. Christopher Garcia

发表

Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling

Hans Clevers, Junlei Chang, Claudia y. Janda, 2017, Nat..

De novo design of potent and selective mimics of IL-2 and IL-15

Brian D. Weitzner, Brian D. Weitzner, David Baker, 2019, Nature.

Author response: Deconstruction of the beaten Path-Sidestep interaction network provides insights into neuromuscular system development

Siamak K Sorooshyari, Hanqing Li, K. Christopher Garcia, 2017 .

Exploiting a natural conformational switch to engineer an Interleukin-2 superkine

Vijay S. Pande, K. Christopher Garcia, Gregory R. Bowman, 2012, Nature.

Stress-testing the relationship between T cell receptor/peptide-MHC affinity and cross-reactivity using peptide velcro

K. Christopher Garcia, Michael E. Birnbaum, Xinbo Yang, 2018, Proceedings of the National Academy of Sciences.

Structure of the immunodominant surface antigen from the Toxoplasma gondii SRS superfamily

K. Christopher Garcia, K. Garcia, J. Boothroyd, 2002, Nature Structural Biology.

Structural basis for chemokine recognition and activation of a viral G protein–coupled receptor

A. J. Venkatakrishnan, Ron O. Dror, John S. Burg, 2014, Science.

Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding

William A. Goddard, Jay T. Groves, Ronald D. Vale, 2018, Cell.

Structural Comparison of Allogeneic and Syngeneic T Cell Receptor–Peptide-Major Histocompatibility Complex Complexes

Vasso Apostolopoulos, Markus G. Rudolph, Mingdong Huang, 2002, The Journal of experimental medicine.

How the T Cell Receptor Sees Antigen—A Structural View

K. Christopher Garcia, Erin J. Adams, E. Adams, 2005, Cell.

Distinct CDR3 Conformations in TCRs Determine the Level of Cross-Reactivity for Diverse Antigens, but Not the Docking Orientation1

David M. Kranz, Jennifer D. Stone, K. Christopher Garcia, 2008, The Journal of Immunology.

Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem cell self-renewal

Irving L. Weissman, Junlei Chang, Tarjei S. Mikkelsen, 2017, Nature.

Kinetics and thermodynamics of T cell receptor– autoantigen interactions in murine experimental autoimmune encephalomyelitis

Raimund J. Ober, K. Christopher Garcia, K. Garcia, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Engineered SIRPα Variants as Immunotherapeutic Adjuvants to Anticancer Antibodies

Jens-Peter Volkmer, Irving L. Weissman, K. Christopher Garcia, 2013, Science.

Two-step binding mechanism for T-cell receptor recognition of peptide–MHC

Mark M. Davis, K. Christopher Garcia, Delphine S. Tuot, 2002, Nature.

Data publication with the structural biology data grid supports live analysis

Oleg V. Tsodikov, Stephen C. Blacklow, Amedeo Caflisch, 2016, Nature Communications.

Mechanistic and structural insights into the proteolytic activation of Vibrio cholera MARTX toxin

K. Christopher Garcia, Matthew Bogyo, Aimee Shen, 2009, Nature chemical biology.

Control of Synaptic Connectivity by a Network of Drosophila IgSF Cell Surface Proteins

Hugo J. Bellen, K. Christopher Garcia, Michael E. Birnbaum, 2015, Cell.

The Structure of Interleukin-2 Complexed with Its Alpha Receptor

K. Christopher Garcia, Martin J. Boulanger, K. Garcia, 2005, Science.

Human LilrB2 Is a β-Amyloid Receptor and Its Murine Homolog PirB Regulates Synaptic Plasticity in an Alzheimer’s Model

Bradley T. Hyman, Carla J. Shatz, K. Christopher Garcia, 2013, Science.

Structural interplay between germline and adaptive recognition determines TCR-peptide-MHC cross-reactivity

David M. Kranz, Sachdev S. Sidhu, K. Christopher Garcia, 2015, Nature Immunology.

Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes

Purvesh Khatri, David Baltimore, Mark M. Davis, 2017, Cell.

Tuning Cytokine Receptor Signaling by Reorienting Dimer Geometry with Surrogate Ligands Graphical

Irving L. Weissman, Samuel Demharter, Jacob Piehler, 2015 .

An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

Robyn L. Stanfield, K. Christopher Garcia, Ian A. Wilson, 1996, Science.

Solution mapping of T cell receptor docking footprints on peptide-MHC

David M. Kranz, K. Christopher Garcia, Joseph D. Puglisi, 2007, Proceedings of the National Academy of Sciences.

Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity

Byoung Choul Kim, Cheng Zhu, Taekjip Ha, 2017, Science.

Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency

Jacob Piehler, K. Christopher Garcia, Christoph Thomas, 2015, Science Signaling.

Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands

Irving L. Weissman, Samuel Demharter, Jacob Piehler, 2015, Cell.

Structural elucidation of the m157 mouse cytomegalovirus ligand for Ly49 natural killer cell receptors

K. Christopher Garcia, Martin J. Boulanger, Lewis L. Lanier, 2007, Proceedings of the National Academy of Sciences.

In vivo molecular imaging for immunotherapy using ultra-bright near-infrared-IIb rare-earth nanoparticles

Yijun Yang, Zhuoran Ma, Xi Wang, 2019, Nature Biotechnology.

Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System

K. Christopher Garcia, Achsah D. Keegan, K. Garcia, 2008, Cell.

Structure of a γδ T Cell Receptor in Complex with the Nonclassical MHC T22

K. Christopher Garcia, Erin J. Adams, E. Adams, 2005, Science.