Debby Long

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Title Discovery of Oral VEGFR-2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular Degeneration

J. Sivak, Fupeng Ma, P. Tarsa, 2018 .

Discovery of Oral VEGFR-2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular Degeneration.

J. Sivak, B. Jaffee, Fupeng Ma, 2015, Journal of medicinal chemistry.

Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.

Thomas M. Smith, N. Gradoux, Jian Ding, 2020, Journal of medicinal chemistry.

Phase I study of single agent NIZ985, a recombinant heterodimeric IL-15 agonist, in adult patients with metastatic or unresectable solid tumors

Niladri Roy Chowdhury, N. R. Chowdhury, E. L. Potter, 2021, Journal for ImmunoTherapy of Cancer.

Pharmacologic Uncoupling of Angiogenesis and Inflammation during Initiation of Pathological Corneal Neovascularization*

J. Sivak, B. Jaffee, R. Cepeda, 2011, The Journal of Biological Chemistry.

An effective prodrug strategy to selectively enhance ocular exposure of a cannabinoid receptor (CB1/2) agonist.

J. Sivak, M. Mclaughlin, B. Jaffee, 2013, Journal of medicinal chemistry.

The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration.

J. Sivak, B. Jaffee, Fupeng Ma, 2018, Journal of medicinal chemistry.

Long-acting protein drugs for the treatment of ocular diseases

T. Dryja, B. Jaffee, C. Bigelow, 2017, Nature Communications.

Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway.

N. Gradoux, A. Vulpetti, B. Jaffee, 2019, Journal of medicinal chemistry.

Application of Imaging Mass Spectrometry to Assess Ocular Drug Transit

M. Mogi, P. Rudewicz, V. Kansara, 2017, SLAS discovery : advancing life sciences R & D.