Bai‐Yu Lee

发表

Francisella tularensis Enters Macrophages via a Novel Process Involving Pseudopod Loops

M. Horwitz, Bai-Yu Lee, D. Clemens, 2005, Infection and Immunity.

Redox-Triggered Release of Moxifloxacin from Mesoporous Silica Nanoparticles Functionalized with Disulfide Snap-Tops Enhances Efficacy Against Pneumonic Tularemia in Mice.

J. Zink, M. Horwitz, D. Clemens, 2016, Small.

pH-Responsive Isoniazid-Loaded Nanoparticles Markedly Improve Tuberculosis Treatment in Mice.

Jeffrey I Zink, J. Zink, M. Horwitz, 2015, Small.

The Francisella Type VI Secretion System

M. Horwitz, Bai-Yu Lee, D. Clemens, 2018, Front. Cell. Infect. Microbiol..

Atomic Structure of T6SS Reveals Interlaced Array Essential to Function

Z. Zhou, P. Ge, M. Horwitz, 2015, Cell.

Virulent and Avirulent Strains of Francisella tularensis Prevent Acidification and Maturation of Their Phagosomes and Escape into the Cytoplasm in Human Macrophages

M. Horwitz, Bai-Yu Lee, D. Clemens, 2004, Infection and Immunity.

Francisella tularensis Phagosomal Escape Does Not Require Acidification of the Phagosome

M. Horwitz, D. Clemens, Daniel L. Clemens, 2009, Infection and Immunity.

Identification, Recombinant Expression, Immunolocalization in Macrophages, and T-Cell Responsiveness of the Major Extracellular Proteins of Francisella tularensis

M. Horwitz, Bai-Yu Lee, D. Clemens, 2006, Infection and Immunity.

Intracellular Photothermal Delivery for Suspension Cells Using Sharp Nanoscale Tips in Microwells.

M. Teitell, P. Weiss, A. Patananan, 2019, ACS nano.

AI-Enabled Parabolic Response Surface Approach Identifies Ultra Short-Course Near-Universal TB Drug Regimens

M. Horwitz, D. Clemens, Bai‐Yu Lee, 2019, Advanced Therapeutics.

Drug regimens identified and optimized by output-driven platform markedly reduce tuberculosis treatment time

Chih-Ming Ho, M. Horwitz, Xianting Ding, 2017, Nature Communications.

Output-driven feedback system control platform optimizes combinatorial therapy of tuberculosis using a macrophage cell culture model

Chih-Ming Ho, Xianting Ding, Aleidy Silva, 2016, Proceedings of the National Academy of Sciences.

The Mycobacterium bovis Bacille Calmette-Guérin Phagosome Proteome*

B. Gibson, M. Horwitz, B. Schilling, 2009, Molecular & Cellular Proteomics.

Francisella tularensis Live Vaccine Strain deficient in capB and overexpressing the fusion protein of IglA, IglB, and IglC from the bfr promoter induces improved protection against F. tularensis respiratory challenge.

M. Horwitz, Qingmei Jia, R. Bowen, 2016, Vaccine.

A Francisella tularensis Live Vaccine Strain (LVS) Mutant with a Deletion in capB, Encoding a Putative Capsular Biosynthesis Protein, Is Significantly More Attenuated than LVS yet Induces Potent Protective Immunity in Mice against F. tularensis Challenge

M. Horwitz, Bai-Yu Lee, Qingmei Jia, 2010, Infection and Immunity.

Identification of Fur, Aconitase, and Other Proteins Expressed by Mycobacterium tuberculosis under Conditions of Low and High Concentrations of Iron by Combined Two-Dimensional Gel Electrophoresis and Mass Spectrometry

B. Gibson, M. Horwitz, Diane K. Wong, 1999, Infection and Immunity.

Mesoporous Silica Nanoparticles with pH-Sensitive Nanovalves for Delivery of Moxifloxacin Provide Improved Treatment of Lethal Pneumonic Tularemia.

J. Zink, M. Horwitz, D. Clemens, 2015, ACS nano.

Mycobacterium tuberculosis and Legionella pneumophila Phagosomes Exhibit Arrested Maturation despite Acquisition of Rab7

M. Horwitz, Daniel L. Clemens, Bai‐Yu Lee, 2000, Infection and Immunity.

Deviant Expression of Rab5 on Phagosomes Containing the Intracellular Pathogens Mycobacterium tuberculosis andLegionella pneumophila Is Associated with Altered Phagosomal Fate

M. Horwitz, Daniel L. Clemens, Bai‐Yu Lee, 2000, Infection and Immunity.

Massively parallel delivery of large cargo into mammalian cells with light pulses

Ting-Hsiang Wu, Michael A Teitell, Pei-Yu Chiou, 2015, Nature Methods.

Recombinant attenuated Listeria monocytogenes vaccine expressing Francisella tularensis IglC induces protection in mice against aerosolized Type A F. tularensis.

M. Horwitz, Bai-Yu Lee, D. Clemens, 2009, Vaccine.

O-Antigen-Deﬁcient Francisella tularensis Live Vaccine Strain Mutants Are Ingested via an Aberrant Form of Looping Phagocytosis and Show Altered Kinetics of Intracellular Trafﬁcking in Human Macrophages

M. Horwitz, Bai-Yu Lee, Daniel L. Clemens, 2012 .

O-Antigen-Deficient Francisella tularensis Live Vaccine Strain Mutants Are Ingested via an Aberrant Form of Looping Phagocytosis and Show Altered Kinetics of Intracellular Trafficking in Human Macrophages

M. Horwitz, Bai-Yu Lee, D. Clemens, 2011, Infection and Immunity.

Facile Strategy Enabling Both High Loading and High Release Amounts of the Water-Insoluble Drug Clofazimine Using Mesoporous Silica Nanoparticles.

J. Zink, Wei Chen, M. Horwitz, 2018, ACS applied materials & interfaces.

Targeted Intracellular Delivery of Antituberculosis Drugs to Mycobacterium tuberculosis-Infected Macrophages via Functionalized Mesoporous Silica Nanoparticles

Jeffrey I. Zink, Courtney R. Thomas, Huan Meng, 2012, Antimicrobial Agents and Chemotherapy.

Atomic Structure of IglD Demonstrates Its Role as a Component of the Baseplate Complex of the Francisella Type VI Secretion System

Z. Zhou, M. Horwitz, Bai-Yu Lee, 2022, mBio.

Atomic Structure of the Francisella T6SS Central Spike Reveals a Unique α-Helical Lid and a Putative Cargo.

Z. Zhou, M. Horwitz, D. Clemens, 2019, Structure.

Photothermal nanoblades for delivery of large-sized cargo into mammalian cells at high throughput

M. Teitell, M. Horwitz, Bai-Yu Lee, 2016, 2016 IEEE 16th International Conference on Nanotechnology (IEEE-NANO).

The Mycobacterium tuberculosis Phagosome in Human Macrophages Is Isolated from the Host Cell Cytoplasm

M. Horwitz, Bai-Yu Lee, D. Clemens, 2002, Infection and Immunity.

A Pathogen-Specific Cargo Delivery Platform Based on Mesoporous Silica Nanoparticles.

J. Zink, M. Horwitz, Bai-Yu Lee, 2017, Journal of the American Chemical Society.

Ultra-rapid near universal TB drug regimen identified via parabolic response surface platform cures mice of both conventional and high susceptibility

Chih-Ming Ho, M. Horwitz, Bai-Yu Lee, 2018, PloS one.

Efficacy and safety of an innovative short-course regimen containing clofazimine for treatment of drug-susceptible tuberculosis: a clinical trial

Chih-Ming Ho, M. Horwitz, Xianting Ding, 2023, Emerging microbes & infections.

High-Level Heterologous Expression and Secretion in Rapidly Growing Nonpathogenic Mycobacteria of Four Major Mycobacterium tuberculosis Extracellular Proteins Considered To Be Leading Vaccine Candidates and Drug Targets

M. Horwitz, G. Harth, Bai‐Yu Lee, 1998, Infection and Immunity.

T-Cell Epitope Mapping of the Three Most Abundant Extracellular Proteins of Mycobacterium tuberculosis in Outbred Guinea Pigs

M. Horwitz, Bai-Yu Lee, Bai‐Yu Lee, 1999, Infection and Immunity.

Nanoparticle Formulation of Moxifloxacin and Intramuscular Route of Delivery Improve Antibiotic Pharmacokinetics and Treatment of Pneumonic Tularemia in a Mouse Model.

J. Zink, M. Horwitz, Bai-Yu Lee, 2018, ACS infectious diseases.

The metabolic activity of Mycobacterium tuberculosis, assessed by use of a novel inducible GFP expression system, correlates with its capacity to inhibit phagosomal maturation and acidification in human macrophages

M. Horwitz, Bai-Yu Lee, D. Clemens, 2008, Molecular microbiology.

Artificial intelligence enabled parabolic response surface platform identifies ultra-rapid near-universal TB drug treatment regimens comprising approved drugs

Chih-Ming Ho, M. Horwitz, Xianting Ding, 2019, PloS one.

Novel insights into the genetics, biochemistry, and immunocytochemistry of the 30-kilodalton major extracellular protein of Mycobacterium tuberculosis

M. Horwitz, J. Wang, D. Clemens, 1996, Infection and immunity.

Output-driven feedback system control platform optimizes combinatorial therapy of tuberculosis using a macrophage cell culture model

Chih-Ming Ho, M. Horwitz, Xianting Ding, 2016, Proceedings of the National Academy of Sciences.

High-level heterologous expression and secretion in rapidly growing nonpathogenic mycobacteria of four major Mycobacterium tuberculosis extracellular proteins considered to be leading vaccine candidates and drug targets

G. Harth, Bai‐Yu Lee, Marcus A. Horwitz, 1997 .

Redox-Triggered Release of Moxifloxacin from Mesoporous Silica Nanoparticles Functionalized with Disulfide Snap-Tops Enhances Efficacy Against Pneumonic Tularemia in Mice.

J. Zink, M. Horwitz, D. Clemens, 2016, Small.

Identification of macrophage and stress-induced proteins of Mycobacterium tuberculosis.

M. Horwitz, B. Y. Lee, Bai‐Yu Lee, 1995, The Journal of clinical investigation.

Purification, characterization, and genetic analysis of Mycobacterium tuberculosis urease, a potentially critical determinant of host-pathogen interaction

M. Horwitz, D. Clemens, B Y Lee, 1995, Journal of bacteriology.

Characterization of the major membrane protein of virulent Mycobacterium tuberculosis

P. Brennan, S. Hefta, B. Y. Lee, 1992, Infection and immunity.