J. Johnston

发表

RYR2 Channel Inhibition Is the Principal Mechanism 0f Flecainide Action in CPVT.

B. Knollmann, D. Laver, Daniel J. Blackwell, 2020, Circulation research.

MDM2 Antagonists Counteract Drug-Induced DNA Damage

G. Ayers, D. Flaherty, Douglas B. Johnson, 2017, EBioMedicine.

Free Radical-Mediated Aryl Amination: A Practical Synthesis of (R)- and (S)-7-Azaindoline α-Amino Acid.

J. Srinivasan, J. N. Johnston, Heather E Burks, 2005, Synthesis.

Nonconventional carbon additions to azomethines. aryl amination/indoline synthesis by direct aryl radical addition to azomethine nitrogen.

E. Prabhakaran, M. Plotkin, J. N. Johnston, 2001, Organic letters.

Catalytic enantioselective Michael additions to unsaturated ester derivatives using chiral copper(II) Lewis acid complexes.

M. Willis, D. Evans, J. N. Johnston, 1999, Organic letters.

Organocatalytic, Diastereo- and Enantioselective Synthesis of Nonsymmetric cis-Stilbene Diamines: A Platform for the Preparation of Single-Enantiomer cis-Imidazolines for Protein–Protein Inhibition

Tyler A. Davis, Jaeki Min, Kristin E. Finch, 2014, The Journal of organic chemistry.

Direct Observation and Analysis of the Halo-Amino-Nitro Alkane Functional Group.

Michael S. Crocker, M. Pink, Kazuyuki Tokumaru, 2019, Chem.

A convergent synthesis of 1,3,4-oxadiazoles from acyl hydrazides under semiaqueous conditions† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc00195a Click here for additional data file.

Kazuyuki Tokumaru, J. N. Johnston, J. Johnston, 2017, Chemical science.

‘Umpolung’ Reactivity in Semiaqueous Amide and Peptide Synthesis

Bo Shen, Bo Shen, Dawn M. Makley, 2010, Nature.

IAN‐Amines: Direct Entry to a Chiral C2‐Symmetric Zirconium(IV) β‐Diketimine Complex

J. N. Johnston, Sarah B. Cortright, J. Johnston, 2002 .

VNI cures acute and chronic experimental Chagas disease.

M. Waterman, P. Nde, Candice A. Johnson, 2013, The Journal of infectious diseases.

Enantioselective Addition of Bromonitromethane to Aliphatic N-Boc Aldimines Using a Homogeneous Bifunctional Chiral Organocatalyst.

Kenneth E. Schwieter, J. N. Johnston, J. Johnston, 2015, ACS catalysis.

Rapid synthesis of cyclic oligomeric depsipeptides with positional, stereochemical, and macrocycle size distribution control

Suzanne M. Batiste, J. N. Johnston, J. Johnston, 2016, Proceedings of the National Academy of Sciences.

Synthesis and biological evaluation of flavonoids and related compounds as gastroprotective agents

J. N. Johnston, J. Ares, P. Outt, 1996 .

To protonate or alkylate? Stereoselective Brønsted acid catalysis of C-C bond formation using diazoalkanes.

J. N. Johnston, H. Muchalski, Timothy L. Troyer, 2010, Angewandte Chemie.

Enantioselective iodolactonization to prepare ε-lactone rings using hypervalent iodine

J. N. Johnston, Jenna L. Payne, Zihang Deng, 2022, Chemical science.

Comparison of testing saliva and serum for detection of antibody to human immunodeficiency virus in Jamaica, West Indies.

W. Brown, A. Delk, B. Bain, 2000, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

Total synthesis of the lycopodium alkaloid (+)-serratezomine A.

J. N. Johnston, Julie A Pigza, A. Chandra, 2009, Journal of the American Chemical Society.

Synthesis of an advanced intermediate en route to the mitomycin natural products.

J. Srinivasan, J. N. Johnston, Amie L. Williams, 2006, Organic letters.

Characterization of Staphylococcus aureus infections in children with Down syndrome.

S. Kaplan, E. Mason, K. Hulten, 2015, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.

Adaptation of a Small-Molecule Hydrogen-Bond Donor Catalyst to an Enantioselective Hetero-Diels–Alder Reaction Hypothesized for Brevianamide Biosynthesis

Daniel J Sprague, J. N. Johnston, Brandon A Vara, 2015, Organic letters.

Enantioselective Synthesis of cis- and trans-Cycloheptyl β-Fluoro Amines by Sequential aza-Henry Addition/Ring-Closing Metathesis.

J. N. Johnston, Jade A Bing, J. Johnston, 2023, Organic letters.

Enantioselective Organocatalytic Amine-Isocyanate Capture-Cyclization: Regioselective Alkene Iodoamination for the Synthesis of Chiral Cyclic Ureas.

Thomas J. Struble, M. Pink, J. N. Johnston, 2018, ACS catalysis.

A case study in biomimetic total synthesis: polyolefin carbocyclizations to terpenes and steroids.

J. N. Johnston, Ryan A. Yoder, J. Johnston, 2005, Chemical reviews.

Continuous Platform to Generate Nitroalkanes On-Demand (in situ) using Peracetic Acid-Mediated Oxidation in a PFA Pipes-in-Series Reactor.

Martin D. Johnson, M. Yates, S. May, 2018, Organic process research & development.

On-Demand Complex Peptide Synthesis: An Aspirational (and Elusive?) Goal for Peptide Synthesis.

Kenneth E. Schwieter, J. Johnston, 2016, Journal of the American Chemical Society.

Biomimetic Desymmetrization of a Carboxylic Acid.

M. Pink, J. N. Johnston, Michael W. Danneman, 2018, Journal of the American Chemical Society.

Chromium(VI) Oxide–3,5‐Dimethylpyrazole

J. N. Johnston, J. Johnston, 2001 .

Enantioselective Synthesis of D‐α‐Amino Amides from Aliphatic Aldehydes.

Kenneth E. Schwieter, J. Johnston, 2015 .

Catalytic, Enantioselective Synthesis of Cyclic Carbamates from Dialkyl Amines by CO2-Capture: Discovery, Development, and Mechanism.

Thomas J. Struble, N. Schley, Mahesh Vishe, 2019, Journal of the American Chemical Society.

Total synthesis of the chlorine-containing hapalindoles K, A, and G.

J. N. Johnston, A. Chandra, J. Johnston, 2011, Angewandte Chemie.

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space

Jared T. Shaw, Derek S. Tan, D. E. Olson, 2018, ACS central science.

Cluster Preface: Alkene Halofunctionalization

T. Rovis, J. N. Johnston, J. Johnston, 2018, Synlett.

Exercise Causes Arrhythmogenic Remodeling of Intracellular Calcium Dynamics in Plakophilin-2–Deficient Hearts

B. Knollmann, A. Lundby, M. Delmar, 2022, Circulation.

Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic

R. Cornea, B. Knollmann, Daniel J. Blackwell, 2019, Proceedings of the National Academy of Sciences.

Silyl Imine Electrophiles in Enantioselective Catalysis: A Rosetta Stone for Peptide Homologation, Enabling Diverse N-Protected Aryl Glycines from Aldehydes in Three Steps

Dawn M. Makley, J. N. Johnston, J. Johnston, 2014, Organic letters.

Discovery of competing anaerobic and aerobic pathways in umpolung amide synthesis allows for site-selective amide 18O-labeling

Bo Shen, J. N. Johnston, Jessica P. Shackleford, 2011, Proceedings of the National Academy of Sciences.

Total synthesis of the Lycopodium alkaloid serratezomine A using free radical-mediated vinyl amination to prepare a β-stannyl enamine linchpin.

M. Pink, J. N. Johnston, Julie A Pigza, 2013, The Journal of organic chemistry.

P-Chiral Phosphoramidates from a Catalytic Asymmetric Halocyclization

M. Pink, B. List, M. Monaco, 2015, Synfacts.

A Preparation of enantiomerically enriched axially chiral beta-diketimines: synthesis of (-)- and (+)-IAN amine.

Sarah Luesse, J. Wilt, Brittany R Perkins, 2008, Organic letters.

Enantioselective small molecule synthesis by carbon dioxide fixation using a dual Brønsted acid/base organocatalyst.

Thomas J. Struble, J. N. Johnston, Weiwei Wang, 2015, Journal of the American Chemical Society.

Enantioenriched axially chiral β-diketimines: Determination of the IAN-amine barrier to atropisomerization

Ryan A. Yoder, Sarah B. Cortright, J. Johnston, 2004 .

A diastereo- and enantioselective synthesis of alpha-substituted anti-alpha,beta-diaminophosphonic acid derivatives.

M. Pink, J. N. Johnston, J. Wilt, 2008, Chemical communications.

Preparation of a protected phosphoramidon precursor via an H-phosphonate coupling strategy.

Matthew G. Donahue, J. N. Johnston, J. Johnston, 2006, Bioorganic & medicinal chemistry letters.

RyR2 Binding of an Antiarrhythmic Cyclic Depsipeptide Mapped Using Confocal Fluorescence Lifetime Detection of FRET

A. Zima, E. Bovo, B. Svensson, 2023, bioRxiv.

Ring Size as an Independent Variable in Cyclooligomeric Depsipeptide Antiarrhythmic Activity.

B. Knollmann, Daniel J. Blackwell, J. N. Johnston, 2021, ACS medicinal chemistry letters.

STUDIES DIRECTED TOWARD THE TOTAL SYNTHESIS OF POLYCAVERNOSIDE A. ENANTIOSELECTIVE SYNTHESIS OF THE DISACCHARIDE COMPONENT

L. Paquette, J. N. Johnston, J. Johnston, 1995 .

The inverted ketene synthon: a double umpolung approach to enantioselective β2,3-amino amide synthesis† †Electronic supplementary information (ESI) available: Complete experimental details and analytical data for all new compounds. See DOI: 10.1039/c8sc04330b

J. N. Johnston, Mahesh Vishe, J. Johnston, 2018, Chemical science.

Chiral proton catalysis: a catalytic enantioselective direct aza-Henry reaction.

J. N. Johnston, Benjamin M. Nugent, Ryan A. Yoder, 2004, Journal of the American Chemical Society.

The Formation of Impossible Rings in Macrocyclooligomerizations for Cyclodepsipeptide Synthesis: The 18-from-12 Paradox.

J. N. Johnston, Abigail N. Smith, J. Johnston, 2021, The Journal of organic chemistry.

Use of comparative triazolinium triflate fragmentation rates as a tool to assay relative competency of Brønsted bases in N-->N proton transfer.

Matthew G. Donahue, J. N. Johnston, K. Hong, 2009, Bioorganic & medicinal chemistry letters.

Stereoselective synthesis of complex polycyclic aziridines: use of the Brønsted acid-catalyzed aza-Darzens reaction to prepare an orthogonally protected mitomycin C intermediate with maximal convergency.

J. Srinivasan, J. Huffman, J. N. Johnston, 2011, Chemical communications.

Fluorine-induced diastereodivergence discovered in an equally rare enantioselective syn-aza-Henry reaction

N. Schley, J. N. Johnston, Jade A Bing, 2022, Chemical science.

Preparation of H,(4) PyrrolidineQuin-BAM (PBAM).

Tyler A. Davis, Aspen C Chun, Kenneth E. Schwieter, 2014, Organic syntheses; an annual publication of satisfactory methods for the preparation of organic chemicals.

Origins of selectivity in Brønsted acid-promoted diazoalkane-azomethine reactions (the aza-Darzens aziridine synthesis).

J. N. Johnston, H. Muchalski, K. Hong, 2011, Organic letters.

On the nature of rate acceleration in the synthesis and fragmentation of triazolines by Brønsted acid: secondary catalysis by water (hydronium triflate).

Matthew G. Donahue, J. N. Johnston, K. Hong, 2008, Journal of the American Chemical Society.

Catalytic, Enantioselective Synthesis of Stilbene cis-Diamines: A Concise Preparation of (-)-Nutlin-3, a Potent p53/MDM2 Inhibitor.

Tyler A. Davis, J. N. Johnston, J. Johnston, 2011, Chemical science.

Development of an Intermittent-Flow Enantioselective Aza-Henry Reaction Using an Arylnitromethane and Homogeneous Brønsted Acid-Base Catalyst with Recycle.

Martin D. Johnson, Michael A. Watkins, Martin D Johnson, 2016, Organic process research & development.

Structure-Activity Relationships for the N-Me- Versus N-H-Amide Modification to Macrocyclic ent-Verticilide Antiarrhythmics.

C. Hopkins, B. Knollmann, N. Schley, 2022, ACS medicinal chemistry letters.

Enantioselective synthesis of d-α-amino amides from aliphatic aldehydes

Kenneth E. Schwieter, J. Johnston, 2015, Chemical science.

Enantioselective synthesis of α-oxy amides via Umpolung amide synthesis.

Bo Shen, J. N. Johnston, Matthew W. Leighty, 2012, Journal of the American Chemical Society.

Alkene diamination using electron-rich amines: hypervalent iodine-promoted inter-/intramolecular C-N bond formation.

J. N. Johnston, K. Hong, J. Johnston, 2014, Organic letters.

Enantioselective and Diastereoselective Mukaiyama—Michael Reactions Catalyzed by Bis(oxazoline) Copper(II) Complexes.

K. Scheidt, Davidr . Evans, M. Willis, 2001 .

ent-Verticilide B1 inhibits type 2 ryanodine receptor channels and is antiarrhythmic in Casq2-/- mice

R. Cornea, B. Knollmann, D. Laver, 2023, bioRxiv.

Bronsted acid-promoted olefin aziridination and formal anti-aminohydroxylation.

J. M. Mahoney, J. N. Johnston, Colin R. Smith, 2005, Journal of the American Chemical Society.

Enantioselective and diastereoselective Mukaiyama-Michael reactions catalyzed by bis(oxazoline) copper(II) complexes.

K. Scheidt, M. Willis, D. Evans, 2001, Journal of the American Chemical Society.

Synthesis of the ABC- and D-ring systems of the indole alkaloid ambiguine G.

J. N. Johnston, R. Viswanathan, A. Chandra, 2007, Organic letters.

Preparation of (-)-Nutlin-3 using enantioselective organocatalysis at decagram scale.

Tyler A. Davis, A. Richmond, A. Vilgelm, 2013, The Journal of organic chemistry.

Preparation of N-Aryl Amides by Epimerization-Free Umpolung Amide Synthesis.

Michael S. Crocker, J. N. Johnston, Michael S Crocker, 2022, Journal of the American Chemical Society.

A one-pot amidation of primary nitroalkanes.

Kenneth E. Schwieter, J. N. Johnston, J. Johnston, 2016, Chemical communications.

Umpolung Amide Synthesis Using Substoichiometric N-Iodosuccinimide (NIS) and Oxygen as a Terminal Oxidant

Bo Shen, Kenneth E. Schwieter, J. N. Johnston, 2014, Organic letters.

Organocatalytic, enantioselective synthesis of VNI: a robust therapeutic development platform for Chagas, a neglected tropical disease.

M. Waterman, F. Villalta, G. Lepesheva, 2012, Organic letters.

Substituted Imidazoline Synthesis: A Diastereo- and Enantioselective aza-Henry Route to a Human Proteasome Modulator.

Daniel J Sprague, J. N. Johnston, J. Johnston, 2020, Organic letters.

PREPARATION OF ISOPROPYL 2-DIAZOACETYL(PHENYL)CARBAMATE.

J. N. Johnston, H. Muchalski, Timothy L. Troyer, 2012, Organic syntheses; an annual publication of satisfactory methods for the preparation of organic chemicals.

Preparation of Benzyl((R )-2-(4-(benzyloxy)phenyl)-2-((tert -Butoxycarbonyl)Amino)Acetyl)-D-Phenylalaninate Using Umpolung Amide Synthesis

S. Tsukanov, Matthew T. Knowe, J. Johnston, 2018, Organic Syntheses.

Brønsted acid-promoted azide–olefin [3 + 2] cycloadditions for the preparation of contiguous aminopolyols: The importance of disiloxane ring size to a diastereoselective, bidirectional approach to zwittermicin A

J. N. Johnston, H. Muchalski, K. Hong, 2010, Beilstein journal of organic chemistry.

Enantioselective Synthesis of β-Fluoro Amines via β-Amino α-Fluoro Nitroalkanes and a Traceless Activating Group Strategy.

J. N. Johnston, Brandon A Vara, J. Johnston, 2016, Journal of the American Chemical Society.

Chiral Brønsted base-promoted nitroalkane alkylation: enantioselective synthesis of sec-alkyl-3-substituted indoles.

J. N. Johnston, Mark C. Dobish, J. Johnston, 2010, Organic letters.

2,6‐Bis[(4S)‐4‐isopropyloxazolin‐2‐yl]pyridine

M. Kozlowski, J. N. Johnston, Alison E. Metz, 2014 .

1,3,4-Oxadiazole and Heteroaromatic-Fused 1,2,4-Triazole Synthesis Using Diverted Umpolung Amide Synthesis

Kazuyuki Tokumaru, K. Bera, J. N. Johnston, 2017, Synthesis.

A Secondary Orbital Effect Involving Fluorine is Responsible for Substrate-Controlled Diastereodivergence in the Catalyzed syn-aza-Henry Reaction of α-Fluoronitroalkanes.

T. Dudding, Ivor Smajlagic, J. Johnston, 2023, Chemistry.

DFT-Based Stereochemical Rationales for the Bifunctional Brønsted Acid/Base-Catalyzed Diastereodivergent and Enantioselective aza-Henry Reactions of α-Nitro Esters.

Thomas J. Struble, T. Dudding, J. N. Johnston, 2021, The Journal of organic chemistry.

The first azacyclopentenyl carbinyl radical isomerizations (ACCRI): independent use of steric and electronic (polarization) effects as gating elements.

J. N. Johnston, R. Viswanathan, Daniel Mutnick, 2003, Journal of the American Chemical Society.

Free radical-mediated vinyl amination: a mild, general pyrrolidinyl enamine synthesis

E. Prabhakaran, J. N. Johnston, Benjamin M. Nugent, 2003 .

Free Radical-Mediated Vinyl Amination: Access to N,N-Dialkyl Enamines and Their β-Stannyl and β-Thio Derivatives

E. Prabhakaran, J. N. Johnston, Kristen E. Nailor, 2002 .

Achiral counterion control of enantioselectivity in a Brønsted acid-catalyzed iodolactonization.

Mark C. Dobish, J. Johnston, 2012, Journal of the American Chemical Society.

A diastereo- and enantioselective synthesis of alpha-substituted syn-alpha,beta-diamino acids.

Anand Singh, J. N. Johnston, J. Johnston, 2008, Journal of the American Chemical Society.

Chiral proton catalysis: enantioselective Brønsted acid catalyzed additions of nitroacetic acid derivatives as glycine equivalents.

Anand Singh, Bo Shen, J. N. Johnston, 2007, Journal of the American Chemical Society.

Brønsted acid activation of alpha-diazo imide: a syn-selective glycolate Mannich reaction.

J. N. Johnston, H. Muchalski, Timothy L. Troyer, 2009, Chemical communications.

Total synthesis of the chlorine-containing hapalindoles K, A, and G.

A. Chandra, J. Johnston, 2011, Angewandte Chemie.

Total synthesis of the lycopodium alkaloid (+)-serratezomine A.

Julie A Pigza, A. Chandra, Jeong-seok Han, 2009, Journal of the American Chemical Society.

Free radical-mediated aryl amination and its use in a convergent [3 + 2] strategy for enantioselective indoline alpha-amino acid synthesis.

E. Prabhakaran, M. Plotkin, J. N. Johnston, 2003, Journal of the American Chemical Society.

Bifunctional asymmetric catalysis: amplification of Brønsted basicity can orthogonally increase the reactivity of a chiral Brønsted acid.

Tyler A. Davis, J. N. Johnston, J. Wilt, 2010, Journal of the American Chemical Society.