Amin Rostami-Hodjegan

发表

The Simcyp Population Based Simulator: Architecture, Implementation, and Quality Assurance

Kairui Feng, Masoud Jamei, Steve Marciniak, 2013, In Silico Pharmacology.

Examining the Use of a Mechanistic Model to Generate an In Vivo/In Vitro Correlation: Journey Through a Thought Process

Nikunjkumar Patel, Marilyn N. Martinez, Masoud Jamei, 2016, The AAPS Journal.

Combining the ‘bottom up’ and ‘top down’ approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data

Leon Aarons, Amin Rostami-Hodjegan, Nikolaos Tsamandouras, 2015, British journal of clinical pharmacology.

Assessment of algorithms for predicting drug-drug interactions via inhibition mechanisms: comparison of dynamic and static models.

Amin Rostami-Hodjegan, Aleksandra Galetin, Eleanor J Guest, 2009, British journal of clinical pharmacology.

Past, Present, and Future of Bioequivalence: Improving Assessment and Extrapolation of Therapeutic Equivalence for Oral Drug Products.

Malcolm Rowland, Rodrigo Cristofoletti, Amin Rostami-Hodjegan, 2018, Journal of pharmaceutical sciences.

Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

Amin Rostami-Hodjegan, G. Tucker, A. Rostami-Hodjegan, 2007, Nature Reviews Drug Discovery.

Physiologically based mechanistic modelling to predict complex drug-drug interactions involving simultaneous competitive and time-dependent enzyme inhibition by parent compound and its metabolite in both liver and gut - the effect of diltiazem on the time-course of exposure to triazolam.

Masoud Jamei, Amin Rostami-Hodjegan, Geoffrey T Tucker, 2010, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

The effects of portal shunts on intestinal cytochrome P450 3A activity

Amin Rostami-Hodjegan, Geoffrey T Tucker, G. Tucker, 2002, Hepatology.

Influence of Dose, Cigarette Smoking, Age, Sex, and Metabolic Activity on Plasma Clozapine Concentrations: A Predictive Model and Nomograms to Aid Clozapine Dose Adjustment and to Assess Compliance in Individual Patients

Amin Rostami-Hodjegan, Geoffrey T Tucker, Robert J Flanagan, 2004, Journal of clinical psychopharmacology.

Cytochrome P450 3A expression and activity in the human small intestine

Amin Rostami-Hodjegan, Geoffrey T Tucker, G. Tucker, 2004, Clinical pharmacology and therapeutics.

The impact of experimental design on assessing mechanism-based inactivation of CYP2D6 by MDMA (Ecstasy)

Amir Heydari, Amin Rostami-Hodjegan, Karen Rowland-Yeo, 2006, Journal of psychopharmacology.

Prediction of intestinal first-pass drug metabolism.

Masoud Jamei, Amin Rostami-Hodjegan, Geoffrey T Tucker, 2007, Current drug metabolism.

3.9. Toxicokinetics and Metabolism

Vera Rogiers, Sandra Coecke, Amin Rostami-Hodjegan, 2005, Alternatives to laboratory animals : ATLA.

The effects of dose staggering on metabolic drug-drug interactions.

Amin Rostami-Hodjegan, Geoffrey T Tucker, Maria Kjellsson, 2003, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.

John C Lipscomb, Amin Rostami-Hodjegan, Alan R Boobis, 2007, Current drug metabolism.

Implications of mechanism-based inhibition of CYP2D6 for the pharmacokinetics and toxicity of MDMA

Amir Heydari, Masoud Jamei, Amin Rostami-Hodjegan, 2006, Journal of psychopharmacology.

The use of mechanistic DM-PK-PD modelling to assess the power of pharmacogenetic studies -CYP2C9 and warfarin as an example.

Amin Rostami-Hodjegan, Geoffrey T Tucker, G. Tucker, 2007, British journal of clinical pharmacology.

Incorporating In Vitro Information on Drug Metabolism Into Clinical Trial Simulations to Assess the Effect of CYP2D6 Polymorphism on Pharmacokinetics and Pharmacodynamics: Dextromethorphan as a Model Application

Saeed Rezaee, Amin Rostami-Hodjegan, Geoffrey T Tucker, 2007, Journal of clinical pharmacology.