Craig W Lindsley

发表

CNS Pathogens: A Special Issue of ACS Chemical Neuroscience.

Craig W Lindsley, 2020, ACS chemical neuroscience.

Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics.

Lisa Bastarache, Joshua C Denny, Dan M Roden, 2017, Assay and drug development technologies.

Confronting Racism in Chemistry Journals

Sharon Hammes-Schiffer, Sébastien Lecommandoux, Joan-Emma Shea, 2020, J. Chem. Inf. Model..

Label-free detection of G protein-SNARE interactions and screening for small molecule modulators.

Craig W Lindsley, H. Hamm, C. Lindsley, 2012, ACS chemical neuroscience.

Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375).

Peter Chase, P Jeffrey Conn, Craig W Lindsley, 2013, Journal of medicinal chemistry.

Recent progress in the discovery and development of negative allosteric modulators of mGluR5.

Craig W Lindsley, C. Lindsley, K. A. Emmitte, 2009, Current opinion in drug discovery & development.

Ligand-based virtual screen for the discovery of novel M5 inhibitor chemotypes.

Jens Meiler, P Jeffrey Conn, Craig W Lindsley, 2016, Bioorganic & medicinal chemistry letters.

Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors.

Zhijian Zhao, Craig W Lindsley, J. Huff, 2005, Bioorganic & medicinal chemistry letters.

Small molecule protein-protein inhibitors for the p53-MDM2 interaction.

Craig W Lindsley, C. Lindsley, Anna S Dudkina, 2007, Current topics in medicinal chemistry.

Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs).

P Jeffrey Conn, Craig W Lindsley, Colleen M Niswender, 2009, Journal of medicinal chemistry.

Application of combinatorial chemistry science on modern drug discovery.

Craig W Lindsley, J. P. Kennedy, C. Lindsley, 2008, Journal of combinatorial chemistry.

Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Reveals Chemical and Functional Diversity and In Vivo Activity in Rat Behavioral Models of Anxiolytic and Antipsychotic Activity

P Jeffrey Conn, Craig W Lindsley, Colleen M Niswender, 2010, Molecular Pharmacology.

Identification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site.

Jens Meiler, P Jeffrey Conn, Jeffrey L. Mendenhall, 2014, ACS chemical neuroscience.

Discovery and SAR of a novel series of GIRK1/2 and GIRK1/4 activators.

Kristian Kaufmann, Craig W Lindsley, C. Lindsley, 2013, Bioorganic & medicinal chemistry letters.

Discovery, Synthesis, and Structure Activity Relationship of a Series of N-Aryl- bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener.

Haibo Yu, Meng Wu, Craig W Lindsley, 2011, ACS chemical neuroscience.

Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.

P Jeffrey Conn, Craig W Lindsley, J. Huff, 2004, Journal of medicinal chemistry.

Inhibition of the TRPC5 ion channel protects the kidney filter.

Craig W Lindsley, Antonio Riccio, C. Lindsley, 2013, The Journal of clinical investigation.

Classics in chemical neuroscience: clozapine.

Craig W Lindsley, Cody J. Wenthur, C. Lindsley, 2013, ACS chemical neuroscience.

"Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology.

P Jeffrey Conn, Craig W Lindsley, C. Lindsley, 2011, Biochemistry.

Allosteric modulation of the M1 muscarinic acetylcholine receptor: improving cognition and a potential treatment for schizophrenia and Alzheimer's disease.

Craig W Lindsley, Bruce J. Melancon, Bruce J Melancon, 2013, Drug discovery today.

A Novel Selective Allosteric Modulator Potentiates the Activity of Native Metabotropic Glutamate Receptor Subtype 5 in Rat Forebrain

P Jeffrey Conn, Craig W Lindsley, C. Lindsley, 2004, Journal of Pharmacology and Experimental Therapeutics.

Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-Triazaspiro[4.5]decane Core: discovery of Ml298 and Ml299 that decrease invasive migration in U87-MG glioblastoma cells.

Craig W Lindsley, Paul G Thomas, Sarah A. Scott, 2013, Journal of medicinal chemistry.

Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4)

Peter Hodder, Louis Scampavia, Franck Madoux, 2015, Journal of biomolecular screening.

A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.

P Jeffrey Conn, Craig W Lindsley, Tsing-Bau Chen, 2003, Molecular pharmacology.

Allosteric modulation of kinases and GPCRs: design principles and structural diversity.

Craig W Lindsley, C. Lindsley, E. Lebois, 2008, Current opinion in chemical biology.

Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors.

Zhijian Zhao, Craig W Lindsley, J. Huff, 2005, Bioorganic & medicinal chemistry letters.

Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia.

Craig W Lindsley, C. Lindsley, Carrie K Jones, 2009, Trends in pharmacological sciences.

Phosphodiesterase 10 A Regulates Alcohol and Saccharin Self-Administration in Rats

Robert L Barry, John C Gore, P Jeffrey Conn, 2014 .

Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe.

Charles C Hong, Craig W Lindsley, C. Lindsley, 2013, Bioorganic & medicinal chemistry letters.

Probing the Metabotropic Glutamate Receptor 5 (mGlu5) Positive Allosteric Modulator (PAM) Binding Pocket: Discovery of Point Mutations That Engender a “Molecular Switch” in PAM Pharmacology

Jens Meiler, P Jeffrey Conn, Craig W Lindsley, 2013, Molecular Pharmacology.