Shou-wu Ma

发表

The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety.

V. Hruby, H. Yamamura, T. Vanderah, 2009, Bioorganic & medicinal chemistry.

The cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues.

V. Hruby, A. Mollica, Cristina Campestre, 2012, Journal of medicinal chemistry.

cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues: part 2.

V. Hruby, A. Mollica, L. Mannina, 2012, Journal of medicinal chemistry.

The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.

V. Hruby, E. Navratilova, H. Yamamura, 2008, Journal of medicinal chemistry.

Synthesis of Stable and Potent δ/μ Opioid Peptides: Analogues of H-Tyr-c[d-Cys-Gly-Phe-d-Cys]-OH by Ring-Closing Metathesis

V. Hruby, A. Mollica, L. Mannina, 2007 .

Synthesis and biological activity of the first cyclic biphalin analogues.

V. Hruby, A. Mollica, F. Porreca, 2006, Bioorganic & medicinal chemistry letters.

Dynorphin A activates bradykinin receptors to maintain neuropathic pain

Qingmin Chen, F. Porreca, M. Ossipov, 2006, Nature Neuroscience.

Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors.

V. Hruby, F. Porreca, J. Lai, 2007, Journal of medicinal chemistry.

Design, Synthesis, and Biological Evaluation of Novel Bifunctional C-Terminal-Modified Peptides for δ/μ Opioid Receptor Agonists and Neurokinin-1 Receptor Antagonists

V. Hruby, E. Navratilova, H. Yamamura, 2007 .

Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists.

V. Hruby, E. Navratilova, H. Yamamura, 2007, Journal of medicinal chemistry.

Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists.

V. Hruby, E. Navratilova, H. Yamamura, 2009, Journal of medicinal chemistry.

Development of potent μ and δ opioid agonists with high lipophilicity.

V. Hruby, T. Vanderah, F. Porreca, 2011, Journal of medicinal chemistry.

Pharmacological characterization of the cloned kappa opioid receptor as a kappa1b subtype

R. Rothman, F. Porreca, J. Lai, 1994, Neuroreport.

‘Knock-down’ of spinal CB1 receptors produces abnormal pain and elevates spinal dynorphin content in mice

F. Porreca, M. Ossipov, J. Lai, 2002, Pain.

PII: S0304-3959(02)00302-0

F. Porreca, M. Ossipov, J. Lai, 2002 .

Synthesis of constrained analogues of cholecystokinin/opioid chimeric peptides.

James P. Cain, J. Ndungu, V. Hruby, 2006, Tetrahedron letters.

Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.

V. Hruby, H. Yamamura, T. Vanderah, 2011, Journal of medicinal chemistry.

Development of Novel Enkephalin Analogues that Have Enhanced Opioid Activities at Both μ and δ Opioid Receptors

V. Hruby, Chad K. Park, F. Porreca, 2007 .

Effect of anchoring 4-anilidopiperidines to opioid peptides.

V. Hruby, T. Vanderah, F. Porreca, 2013, Bioorganic & medicinal chemistry letters.

Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain.

R. Gillies, V. Hruby, F. Porreca, 2010, Bioorganic & medicinal chemistry letters.

Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at μ and δ opioid receptors

V. Hruby, F. Porreca, J. Lai, 2007 .

Design and Synthesis of Novel Hydrazide-Linked Bifunctional Peptides as δ/μ Opioid Receptor Agonists and CCK-1/CCK-2 Receptor Antagonists

V. Hruby, F. Porreca, J. Lai, 2006 .

Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines.

V. Hruby, E. Navratilova, H. Yamamura, 2010, Journal of medicinal chemistry.

Novel bifunctional peptides as opioid agonists and NK-1 antagonists.

V. Hruby, E. Navratilova, H. Yamamura, 2009, Advances in experimental medicine and biology.

Design of novel peptide ligands which have opioid agonist activity and CCK antagonist activity for the treatment of pain.

V. Hruby, T. Vanderah, F. Porreca, 2003, Life sciences.