Kamelia Behnia

发表

2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase in

Ping Chen, A. Doweyko, Derek J. Norris, 2006, Journal of medicinal chemistry.

Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.

Ping Chen, A. Doweyko, Derek J. Norris, 2004, Journal of medicinal chemistry.

Design of amidobenzimidazole STING receptor agonists with systemic activity

Joseph P. Romano, J. Bertin, J. Adams, 2018, Nature.

Design of amidobenzimidazole STING receptor agonists with systemic activity

J. Bertin, J. Adams, M. Bantscheff, 2018, Nature.

Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils.

K. Behnia, Rongan Zhang, P. Sleph, 2016, Cell Metabolism.

Discovery of Highly Potent Liver X Receptor β Agonists

A. D. Rodrigues, P. Sleph, T. Kirchgessner, 2016, ACS medicinal chemistry letters.

Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase.

David S. Taylor, Brandon L. Parkhurst, E. Liu, 2019, Bioorganic & medicinal chemistry letters.

Sulfonylated Benzothiazoles as Inhibitors of Endothelial Lipase.

David S. Taylor, Michael A. Galella, L. Abell, 2018, ACS medicinal chemistry letters.

Discovery of pyrazine carboxamide CB1 antagonists: the introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series.

Ying Wang, Samuel W Gerritz, William R Ewing, 2007, Bioorganic & medicinal chemistry letters.

Imidazoquinoxaline Src-family kinase p56Lck inhibitors: SAR, QSAR, and the discovery of (S)-N-(2-chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo- [1,5-a]pyrido[3,2-e]pyrazin-6-amine (BMS-279700) as a potent and orally active inhibitor with excellent in vivo antiinflammatory activity.

Ping Chen, A. Doweyko, Derek J. Norris, 2004, Journal of medicinal chemistry.

Benzothiazole-based compounds as potent endothelial lipase inhibitors.

David S. Taylor, R. Wexler, Xiaohong Yin, 2019, Bioorganic & medicinal chemistry letters.

Characterization of a novel and selective CB1 antagonist as a radioligand for receptor occupancy studies.

K. Behnia, N. Murugesan, Z. Gu, 2011, Bioorganic & medicinal chemistry letters.

Reductions in log P improved protein binding and clearance predictions enabling the prospective design of cannabinoid receptor (CB1) antagonists with desired pharmacokinetic properties.

K. Behnia, N. Murugesan, Z. Gu, 2013, Journal of medicinal chemistry.

Author Correction: Design of amidobenzimidazole STING receptor agonists with systemic activity

Joseph P. Romano, J. Bertin, M. Bantscheff, 2019, Nature.

Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors.

Ping Chen, A. Doweyko, Derek J. Norris, 2004, Bioorganic & medicinal chemistry letters.

Design, synthesis, and anti-inflammatory properties of orally active 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha mitogen-activated protein kinase inhibitors.

John Dodd, John S Tokarski, Arthur M Doweyko, 2008, Journal of medicinal chemistry.

Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1H-pyrazol-1-yl)methyl)phosphonate (BMS-820132).

Steven A. Spronk, K. Behnia, J. Barrish, 2022, Journal of medicinal chemistry.

Inhibition of Aldo‐keto Reductases by Phenobarbital Alters Metabolism, Pharmacokinetics and Toxicity of Doxorubicin in Rats

K. Behnia, M. Boroujerdi, Kamelia Behnia, 1999, The Journal of pharmacy and pharmacology.

Estimation of the extent of in vivo formation of a mutagenic aromatic amine from a potent thyromimetic compound: correlation of in vitro and in vivo findings.

A. D. Rodrigues, W. Humphreys, P. Marathe, 2011, Chemical research in toxicology.

Discovery and SAR of aryl hydroxy pyrimidinones as potent small molecule agonists of the GPCR APJ.

Michael C. Myers, A. Nayeem, P. Gargalovic, 2020, Bioorganic & medicinal chemistry letters.

Xenobiotic metabolism by cultured primary porcine hepatocytes.

S. Bhatia, M. Toner, M. Yarmush, 2000, Tissue engineering.

Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) which Demonstrate HDL-C Increase In Vivo.

David S. Taylor, K. Behnia, E. Liu, 2020, Journal of medicinal chemistry.

Investigation of the enterohepatic recirculation of Adriamycin and its metabolites by a linked-rat model

K. Behnia, M. Boroujerdi, Kamelia Behnia, 1998, Cancer Chemotherapy and Pharmacology.

Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils.

Rongan Zhang, P. Sleph, T. Kirchgessner, 2016, Cell metabolism.