David L. Boyle

发表

Toreforant, an orally active histamine H4-receptor antagonist, in patients with active rheumatoid arthritis despite methotrexate: mechanism of action results from a phase 2, multicenter, randomized, double-blind, placebo-controlled synovial biopsy study

R. Thurmond, G. Firestein, W. Barchuk, 2019, Inflammation Research.

Clonal associations of lymphocyte subsets and functional states revealed by single cell antigen receptor profiling of T and B cells in rheumatoid arthritis synovium

S. Raychaudhuri, A. McDavid, L. Moreland, 2023, bioRxiv.

Assessing Researcher Needs for a Virtual Biobank.

Dan Mercola, Brian Gardner, Sarah Dry, 2017, Biopreservation and biobanking.

Receptor Protein Tyrosine Phosphatase α–Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice

N. Bottini, G. Firestein, J. den Hertog, 2015, Arthritis & rheumatology.

Understanding the mechanistic basis in rheumatoid arthritis for clinical response to anti‐CD20 therapy: the B‐cell roadblock hypothesis

D. Boyle, G. Silverman, David L. Boyle, 2008, Immunological reviews.

Mode of action of abatacept in rheumatoid arthritis patients having failed tumour necrosis factor blockade: a histological, gene expression and dynamic magnetic resonance imaging pilot study

A. Radjenovic, P. Emery, G. Firestein, 2008, Annals of the rheumatic diseases.

Defining Inflammatory Cell States in Rheumatoid Arthritis Joint Synovial Tissues by Integrating Single-cell Transcriptomics and Mass Cytometry

Nir Hacohen, Kamil Slowikowski, Andrew Filer, 2018, bioRxiv.

Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis.

G. Firestein, N. Zvaifler, D. Boyle, 1994, Arthritis and rheumatism.

Apoptosis in rheumatoid arthritis: p53 overexpression in rheumatoid arthritis synovium.

G. Firestein, G. Firestein, N. Zvaifler, 1996, The American journal of pathology.

NF-kappa B regulation by I kappa B kinase in primary fibroblast-like synoviocytes.

P. Tak, A. Manning, P. Tak, 1999, Journal of immunology.

Regulation of synoviocyte proliferation, apoptosis, and invasion by the p53 tumor suppressor gene.

E. Seftor, M. Hendrix, E. Seftor, 1998, The American journal of pathology.

AP-1 and NF-kappaB regulation in rheumatoid arthritis and murine collagen-induced arthritis.

A. Manning, G. Firestein, D. Boyle, 1998, Autoimmunity.

The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis

G. Firestein, P. Mease, D. Boyle, 2013, Annals of the rheumatic diseases.

Adenosine inhibits neutrophil degranulation in activated human whole blood: involvement of adenosine A2 and A3 receptors.

D. Boyle, W. Buurman, M. Dentener, 1997, Journal of immunology.

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis.

M. Karin, A. Manning, Lufen Chang, 2001, The Journal of clinical investigation.

Jun N-terminal kinase in rheumatoid arthritis.

A. Manning, G. Firestein, D. Boyle, 1999, The Journal of pharmacology and experimental therapeutics.

Regulation of CS1 fibronectin expression and function by IL-1 in endothelial cells.

G. Firestein, Y. Shi, D. Boyle, 2000, Cellular immunology.

Mechanisms of methotrexate action in rheumatoid arthritis. Selective decrease in synovial collagenase gene expression.

G. Firestein, D. Boyle, M. M. Paine, 1994, Arthritis and rheumatism.

Early synovitis--synoviocytes and mononuclear cells.

G. Firestein, N. Zvaifler, D. Boyle, 1994, Seminars in arthritis and rheumatism.

Assessment of rituximab’s immunomodulatory synovial effects (ARISE trial). 1: clinical and synovial biomarker results

K. Kalunian, G. Firestein, D. Hammaker, 2007, Annals of the rheumatic diseases.

Posttranscriptional regulation of collagenase-1 gene expression in synoviocytes by adenosine receptor stimulation.

G. Firestein, J. Rutter, C. Brinckerhoff, 1997, Arthritis and rheumatism.

Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy

N. Bottini, T. Mustelin, J. Esko, 2015, Science Translational Medicine.

Lipomatosis-associated inflammation and excess collagen may contribute to lower relative resting energy expenditure in women with adiposis dolorosa

K. Herbst, D. Boyle, A. Coviello, 2009, International Journal of Obesity.

Inhibitor of nuclear factor kappaB kinase beta is a key regulator of synovial inflammation.

P. Tak, A. Manning, G. Firestein, 2001, Arthritis and rheumatism.

Multifaceted immune dysregulation characterizes individuals at-risk for rheumatoid arthritis

Ryan A. Peterson, Rizi Ai, G. Firestein, 2023, Nature communications.

Expression and regulation of cryopyrin and related proteins in rheumatoid arthritis synovium

W. Bugbee, D. Boyle, H. Hoffman, 2004, Annals of the rheumatic diseases.

PI3 Kinase (cid:1) Is a Key Regulator of Synoviocyte Function in Rheumatoid Arthritis

G. Firestein, B. Bartok, David L. Boyle, 2022 .

Dominant-negative p53 mutations in rheumatoid arthritis.

D. Green, G. Firestein, Y. Shi, 1999, Arthritis and rheumatism.