J. Bartolome

发表

mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome.

C. Lindsley, P. Conn, S. Stauffer, 2016, Human molecular genetics.

N-Aryl Piperazine Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators Possess Efficacy in Preclinical Models of NMDA Hypofunction and Cognitive Enhancement

M. Caron, S. Jadhav, K. Gregory, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Microsoft Word-32670823-file00.docx

T. Daigle, C. Mackie, H. Lavreysen, 2013 .

Synthesis of novel 3-substituted-2,3-dihydro-1,4-dioxino[2,3-b]pyridines as potential new scaffolds for drug discovery: selective introduction of substituents on the pyridine ring

J. M. Alonso, J. Alcázar, L. Iturrino, 2003 .

Synthesis of Novel 3‐Substituted‐2,3‐dihydro‐1,4‐dioxino[2,3‐b]pyridines as Potential New Scaffolds for Drug Discovery: Selective Introduction of Substituents on the Pyridine Ring.

J. M. Alonso, J. Alcázar, L. Iturrino, 2004 .

Synthesis of novel aza analogues of 2-substituted-2,3-dihydro-1,4-benzodioxins as potential new scaffolds for drug discovery

J. Andrés, J. Alcázar, K. V. Emelen, 2003 .

A decade of progress in the discovery and development of 'atypical' antipsychotics.

G. Macdonald, J. Bartolomé, J. Bartolome, 2010, Progress in medicinal chemistry.

Molecular properties affecting fast dissociation from the D2 receptor.

X. Langlois, G. Macdonald, G. Tresadern, 2011, Bioorganic & medicinal chemistry.

Target 2035 – an update on private sector contributions

T. Willson, S. Knapp, U. Lessel, 2023, RSC medicinal chemistry.

Synthesis and Diels-Alder reactions of N-(tert-butoxycarbonyl)-3-p-tolylsulfinyl-1-benzoquinone-4-imine

M. C. Carreño, A. Urbano, J. Bartolome, 1996 .

Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover.

S. Jadhav, K. Gregory, G. Macdonald, 2012, Bioorganic & medicinal chemistry letters.

Ketomethylene and methyleneamino pseudopeptide analogues of insect allatostatins inhibit juvenile hormone and vitellogenin production in the cockroach Blattella germanica.

M. García-López, R. González-Muñiz, D. Andreu, 1997, Insect biochemistry and molecular biology.

Discovery and SAR of a novel series of non-MPEP site mGlu₅ PAMs based on an aryl glycine sulfonamide scaffold.

G. Macdonald, H. Lavreysen, C. Lindsley, 2012, Bioorganic & medicinal chemistry letters.

mGluR2 positive allosteric modulators: an updated patent review (2013–2018)

J. Cid, A. A. Trabanco, J. Bartolomé, 2019, Expert opinion on therapeutic patents.

Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions

Anna L. Blobaum, G. Macdonald, H. Lavreysen, 2013, Drug Metabolism and Disposition.

DMD052662 2066..2075

Anna L. Blobaum, G. Macdonald, H. Lavreysen, 2013 .

Microsoft Word-JSD_3A4_activation_mGlu5_PAM_revised_final_V4[1]

Anna L. Blobaum, G. Macdonald, H. Lavreysen, 2013 .

N-Aryl Piperazine Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators Possess Efficacy in Preclinical Models of NMDA Hypofunction and Cognitive Enhancement

S. Jadhav, H. Lavreysen, C. Lindsley, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Title: N -aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in pre-clinical models of NMDA hypofunction and cognitive enhancement

T. Daigle, C. Mackie, H. Lavreysen, 2013 .

Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions

H. Lavreysen, C. Lindsley, Margrith E. Mattmann, 2013, Drug Metabolism and Disposition.

DMD052662 2066..2075

H. Lavreysen, C. Lindsley, Margrith E. Mattmann, 2013 .

Effects of dimethyl sulfoxide on the degradation of ribonucleic acid catalyzed by alkali.

J. Bartolomé, F. Orrego, J. Bartolome, 1970, Biochemistry.