Frank Dieterle

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New technologies around biomarkers and their interplay with drug development

Frank Dieterle, Estelle Marrer, F. Dieterle, 2008, Analytical and bioanalytical chemistry.

Chapter 2.1.8 – Biomarkers in the Context of Health Authorities and Consortia

Frank Dieterle, Estelle Marrer, Jacky Vonderscher, 2015 .

Towards consensus practices to qualify safety biomarkers for use in early drug development

Frank D Sistare, Elizabeth Walker, Peter Kasper, 2010, Nature Biotechnology.

Impact of biomarker development on drug safety assessment.

Frank Dieterle, Estelle Marrer, F. Dieterle, 2010, Toxicology and applied pharmacology.

Multi-analyte assay for triazines using cross-reactive antibodies and neural networks.

Günter Gauglitz, Frank Dieterle, Sabine Reder, 2003, Biosensors & bioelectronics.

Renal biomarker qualification submission: a dialog between the FDA-EMEA and Predictive Safety Testing Consortium

Krishna Prasad, Peter Kasper, Jonathan A Phillips, 2010, Nature Biotechnology.

Performance of novel kidney biomarkers in preclinical toxicity studies.

Philip Hewitt, Frank Staedtler, Joseph V Bonventre, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Metabolic profiling technologies for biomarker discovery in biomedicine and drug development.

Götz Schlotterbeck, Alfred Ross, Frank Dieterle, 2006, Pharmacogenomics.

Metabolite projection analysis for fast identification of metabolites in metabonomics. Application in an amiodarone study.

Götz Schlotterbeck, Alfred Ross, Frank Dieterle, 2006, Analytical chemistry.

Next-generation biomarkers for detecting kidney toxicity

Joseph V Bonventre, Frank Dieterle, J. Bonventre, 2010, Nature Biotechnology.

Different approaches to multivariate calibration of nonlinear sensor data

Günter Gauglitz, Stefan Busche, Frank Dieterle, 2004, Analytical and bioanalytical chemistry.

Genetic algorithms and neural networks for the quantitative analysis of ternary mixtures using surface plasmon resonance

Günter Gauglitz, Frank Dieterle, G. Gauglitz, 2003 .

Chapter 3 – NMR Spectroscopy Techniques for Application to Metabonomics

Alfred Ross, Frank Dieterle, H. Senn, 2007 .

Application of metabonomics in a comparative profiling study reveals N-acetylfelinine excretion as a biomarker for inhibition of the farnesyl pathway by bisphosphonates.

Götz Schlotterbeck, Alfred Ross, Frank Dieterle, 2007, Chemical research in toxicology.

Cross-study and cross-omics comparisons of three nephrotoxic compounds reveal mechanistic insights and new candidate biomarkers.

Alexander Amberg, Philip Hewitt, Hans Gmuender, 2011, Toxicology and applied pharmacology.

Growing neural networks for a multivariate calibration and variable selection of time-resolved measurements

Günter Gauglitz, Stefan Busche, Frank Dieterle, 2003 .

Application of metabonomics in a compound ranking study in early drug development revealing drug-induced excretion of choline into urine.

Götz Schlotterbeck, Alfred Ross, Urs Niederhauser, 2006, Chemical research in toxicology.

Tissue-specific, non-invasive toxicity biomarkers: translation from preclinical safety assessment to clinical safety monitoring

Frank Dieterle, Patrick Y Muller, F. Dieterle, 2009, Expert opinion on drug metabolism & toxicology.