William C Hahn

发表

Minimizing the risk of reporting false positives in large-scale RNAi screens

Nir Hacohen, Jan Ellenberg, Norbert Perrimon, 2006, Nature Methods.

Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration

Aviad Tsherniak, Joshua M. Dempster, William C Hahn, 2018, Nature Communications.

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.

Yiling Lu, Gordon B Mills, Bhaskar Dutta, 2009, Cancer cell.

Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers.

William C Hahn, David E Root, Matthew Meyerson, 2011, Cancer discovery.

The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors.

William C Hahn, David H Rowitch, W. Hahn, 2005, Developmental cell.

Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles.

Pablo Tamayo, Heiko Horn, Ted Natoli, 2016, Cancer discovery.

RNF43 is frequently mutated in colorectal and endometrial cancers

Kristian Cibulskis, Joseph Rosenbluh, Gad Getz, 2014, Nature Genetics.

ATARiS: Computational quantification of gene suppression phenotypes from multisample RNAi screens

Pablo Tamayo, Aviad Tsherniak, Rameen Beroukhim, 2013, Genome research.

Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling.

Nikhil Wagle, Levi A Garraway, William C Hahn, 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma.

Juergen Kast, William C Hahn, Kaisa Teittinen, 2009, Cancer research.

Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1

Liliana Goumnerova, Gad Getz, Rameen Beroukhim, 2013, Proceedings of the National Academy of Sciences.

Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens.

Aviad Tsherniak, Joseph A Marsh, William C Hahn, 2018, Cell systems.

Genomic insights into WNT/β-catenin signaling.

Joseph Rosenbluh, William C Hahn, W. Hahn, 2014, Trends in pharmacological sciences.

Mutational processes shape the landscape of TP53 mutations in human cancer

Aviad Tsherniak, Gad Getz, Ted Sharpe, 2018, Nature Genetics.

MYC activity mitigates response to rapamycin in prostate cancer through eukaryotic initiation factor 4E-binding protein 1-mediated inhibition of autophagy.

William C Hahn, Wayne Glover, Massimo Loda, 2009, Cancer research.

High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing.

Nikhil Wagle, Levi A Garraway, William C Hahn, 2012, Cancer discovery.

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells.

William C Hahn, Brent R Stockwell, Sonam Dolma, 2003, Cancer cell.

Role of telomeres and telomerase in the pathogenesis of human cancer.

William C Hahn, W. Hahn, 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Tyrosine kinase pathways modulate tumor susceptibility to natural killer cells.

Stefan Heinrichs, Roberto Bellucci, William C Hahn, 2012, The Journal of clinical investigation.

Requirement for CDK6 in MLL-rearranged acute myeloid leukemia.

Stefan Fröhling, William C Hahn, David E Root, 2013, Blood.

Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase.

William C Hahn, David E Root, Kornelia Polyak, 2009, Cancer cell.

Institutional implementation of clinical tumor profiling on an unselected cancer population.

Marian Harris, Ethan Cerami, Frank C Kuo, 2016, JCI insight.

ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state.

Anne E Carpenter, Mark-Anthony Bray, Andrea Califano, 2014, Cell reports.

Somatic Superenhancer Duplications and Hotspot Mutations Lead to Oncogenic Activation of the KLF5 Transcription Factor.

Aviad Tsherniak, Gavin Ha, William C Hahn, 2017, Cancer discovery.

Sound credit scores and financial decisions despite cognitive aging

Rameen Beroukhim, William C Hahn, Pratiti Bandopadhayay, 2014, Proceedings of the National Academy of Sciences.

Rules for making human tumor cells.

William C Hahn, W. Hahn, R. Weinberg, 2002, The New England journal of medicine.

Proteomic and genetic approaches identify Syk as an AML target.

Tina N. Davis, Steven A Carr, William C Hahn, 2009, Cancer cell.

Oncogenic transformation and experimental models of human cancer.

William C Hahn, W. Hahn, A. Schinzel, 2008, Frontiers in bioscience : a journal and virtual library.

An oncogene–tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-κB

Rameen Beroukhim, William C Hahn, Giuseppe Fedele, 2010, Nature Medicine.

Functional genomics and cancer drug target discovery.

William C Hahn, Jesse S Boehm, W. Hahn, 2010, Current opinion in molecular therapeutics.

The intersection of genetic and chemical genomic screens identifies GSK-3α as a target in human acute myeloid leukemia.

Gabriela Alexe, Giovanni Roti, Nicola Tolliday, 2012, The Journal of clinical investigation.

Towards patient-based cancer therapeutics

Benito Munoz, Michelle Palmer, Paul A Clemons, 2010, Nature Biotechnology.

Oncogenic Transformation by Inhibitor-Sensitive and -Resistant EGFR Mutants

William C Hahn, Matthew Meyerson, William R Sellers, 2005, PLoS medicine.

Emerging insights into the molecular and cellular basis of glioblastoma.

Lynda Chin, William C Hahn, Gavin P Dunn, 2012, Genes & development.

Characterizing genomic alterations in cancer by complementary functional associations

Gabriela Alexe, Chiara Romualdi, Pablo Tamayo, 2016, Nature Biotechnology.

Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target.

William C Hahn, Matthew Meyerson, Shouyong Peng, 2013, Genes & development.

Regulation of in situ to invasive breast carcinoma transition.

Jun Yao, Tatiana Nikolskaya, Yuri Nikolsky, 2008, Cancer cell.

Establishment : adaptation to culture and immortalization

William C Hahn, W. Hahn, 2002 .

The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors.

Mithat Gönen, Tatiana Nikolskaya, Yuri Nikolsky, 2011, The Journal of clinical investigation.

Functional genetics and experimental models of human cancer.

William C Hahn, W. Hahn, T. Roberts, 2004, Trends in molecular medicine.

Lentivirus-delivered stable gene silencing by RNAi in primary cells.

William C Hahn, David M Sabatini, Phillip A Sharp, 2003, RNA.

Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2

Wendy Winckler, Gad Getz, Steven A Carr, 2012, Proceedings of the National Academy of Sciences.

Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion

Kristian Cibulskis, Gad Getz, Shuji Ogino, 2011, Nature Genetics.

Genome-scale loss-of-function screening with a lentiviral RNAi library

Nir Hacohen, William C Hahn, David E Root, 2006, Nature Methods.