David M Sabatini

发表

Minimizing the risk of reporting false positives in large-scale RNAi screens

Nir Hacohen, Jan Ellenberg, Norbert Perrimon, 2006, Nature Methods.

Single Guide RNA Library Design and Construction.

David M Sabatini, Tim Wang, Eric S Lander, 2016, Cold Spring Harbor protocols.

Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning

Polina Golland, Anne E Carpenter, David E Root, 2009, Proceedings of the National Academy of Sciences.

CellProfiler: free, versatile software for automated biological image analysis.

Anne E Carpenter, David M Sabatini, Michael R Lamprecht, 2007, BioTechniques.

CellProfiler Analyst: data exploration and analysis software for complex image-based screens

Polina Golland, Anne E Carpenter, David M Sabatini, 2008, BMC Bioinformatics.

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.

Paul Tempst, David M Sabatini, Hediye Erdjument-Bromage, 2003, Molecular cell.

Rapalogs and mTOR inhibitors as anti-aging therapeutics.

Lan Ye, David M Sabatini, Dudley Lamming, 2013, The Journal of clinical investigation.

mTOR and cancer: many loops in one pathway.

David M Sabatini, D. Sabatini, A. Efeyan, 2009, Current opinion in cell biology.

Large-Scale Single Guide RNA Library Construction and Use for CRISPR-Cas9-Based Genetic Screens.

David M Sabatini, Tim Wang, Eric S Lander, 2016, Cold Spring Harbor protocols.

Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome.

Lei Zhang, Rudolf Jaenisch, David M Sabatini, 2010, Genome research.

The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.

Steven P Gygi, David M Sabatini, S. Gygi, 2014, Cell reports.

Cell-biological applications of transfected-cell microarrays.

David M Sabatini, Randy Z. Wu, D. Sabatini, 2002, Trends in cell biology.

An expanding role for mTOR in cancer.

David M Sabatini, D. Guertin, D. Sabatini, 2005, Trends in molecular medicine.

A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors

Nir Hacohen, Nevan J Krogan, David M Sabatini, 2016, Nature Genetics.

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

Roberto Zoncu, David M Sabatini, D. Sabatini, 2011, Science.

ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP.

Gordon B Mills, David M Sabatini, G. Mills, 2016, Cancer research.

ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state.

Anne E Carpenter, Mark-Anthony Bray, Andrea Califano, 2014, Cell reports.

Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling.

Anne E Carpenter, David M Sabatini, Thouis R Jones, 2011, Genome research.

Guidelines for the use and interpretation of assays formonitoring autophagy (3rd edition)

Sangeeta Khare, Xin Qi, Ying Wang, 2016 .

Defining the role of mTOR in cancer.

David M Sabatini, D. Guertin, D. Sabatini, 2007, Cancer cell.

A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.

Andrew H. Beck, David M Sabatini, Andrew H Beck, 2014, Cancer discovery.

Applications of transfected cell microarrays in high-throughput drug discovery.

David M Sabatini, Randy Z. Wu, D. Sabatini, 2002, Drug discovery today.

Amino acids and mTORC1: from lysosomes to disease.

Roberto Zoncu, David M Sabatini, D. Sabatini, 2012, Trends in molecular medicine.

Lentivirus-delivered stable gene silencing by RNAi in primary cells.

William C Hahn, David M Sabatini, Phillip A Sharp, 2003, RNA.

TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.

Kira Glover-Cutter, David M Sabatini, Dudley Lamming, 2012, Cell metabolism.

Genome-scale loss-of-function screening with a lentiviral RNAi library

Nir Hacohen, William C Hahn, David E Root, 2006, Nature Methods.