Jose A. Fernández

发表

Anticoagulant Responses to Thrombin Are Enhanced During Regression of Atherosclerosis in Monkeys

José A Fernández, J. Griffin, D. Heistad, 2002, Circulation.

Activated Protein C Resistance: Molecular Mechanisms

J. Griffin, J. A. Fernandez, T. Hackeng, 1995, Thrombosis and Haemostasis.

Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice.

José A Fernández, J. Griffin, M. Hessner, 2010, The Journal of clinical investigation.

Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway

José A Fernández, J. Griffin, B. Zlokovic, 2011, Molecular Neurodegeneration.

Species-specific anticoagulant and mitogenic activities of murine protein S

José A Fernández, J. Griffin, B. Zlokovic, 2009, Haematologica.

Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality.

José A Fernández, J. Griffin, F. Castellino, 2009, Blood.

3K3A-Activated Protein C Prevents Microglia Activation, Inhibits NLRP3 Inflammasome and Limits Ocular Inflammation

José A Fernández, D. Weinberger, J. Griffin, 2022, International journal of molecular sciences.

The Apolipoprotein C-I Content of Very-Low-Density Lipoproteins Is Associated with Fasting Triglycerides, Postprandial Lipemia, and Carotid Atherosclerosis

José A Fernández, J. Björkegren, J. Hansen, 2011, Journal of lipids.

Role of protein C inhibitor and tissue factor in fertilization.

José A Fernández, José A. Fernández, M. J. Heeb, 2007, Seminars in thrombosis and hemostasis.

Soluble thrombomodulin is antithrombotic in the presence of neutralising antibodies to protein C and reduces circulating activated protein C levels in primates

José A Fernández, J. Griffin, A. Gruber, 2006, British journal of haematology.

Dermatan Sulfate and LMW Heparin Enhance the Anticoagulant Action of Activated Protein C

José A Fernández, J. Griffin, J. A. Fernandez, 1999, Thrombosis and Haemostasis.

Human Thrombomodulin Knock-In Mice Reveal Differential Effects of Human Thrombomodulin on Thrombosis and Atherosclerosis

José A Fernández, D. Dwyre, J. Griffin, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

José A Fernández, Dong Liu, J. Griffin, 2003, Nature Medicine.

Prothrombin Residues 473–487 Contribute to Factor Va Binding in the Prothrombinase Complex*

José A Fernández, J. Griffin, R. Mesters, 2004, Journal of Biological Chemistry.

Targeting anticoagulant protein S to improve hemostasis in hemophilia.

José A Fernández, J. Griffin, H. Simon, 2018, Blood.

Generation and phenotypic analysis of protein S-deficient mice.

José A Fernández, J. Griffin, R. Chrast, 2009, Blood.

Plasma Lipoproteins, Hemostasis and Thrombosis

José A Fernández, J. Griffin, J H Griffin, 2001, Thrombosis and Haemostasis.

Plasma protein S residues 37–50 mediate its binding to factor Va and inhibition of blood coagulation

José A Fernández, J. Griffin, R. Mesters, 2013, Thrombosis and Haemostasis.

Factor Va increases the affinity of factor Xa for prothrombin: a binding study using a novel photoactivable thiol-specific fluorescent probe.

José A Fernández, J. Griffin, P. Dawson, 2002, Chemistry & biology.

Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model.

José A Fernández, J. Griffin, B. Zlokovic, 2003, Blood cells, molecules & diseases.

Protein S Confers Neuronal Protection During Ischemic/Hypoxic Injury in Mice

José A Fernández, J. Griffin, B. Zlokovic, 2003, Circulation.

Activated protein C and ischemic stroke

José A Fernández, J. Griffin, B. Zlokovic, 2004, Critical care medicine.

Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C

José A Fernández, Dong Liu, J. Griffin, 2004, Nature Medicine.

Activated Protein C Attenuates Experimental Autoimmune Encephalomyelitis Progression by Enhancing Vascular Integrity and Suppressing Microglial Activation

José A Fernández, J. Griffin, R. Milner, 2020, Frontiers in Neuroscience.

2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis: Thrombotic Stroke: Neuroprotective Therapy by Recombinant-Activated Protein C.

José A Fernández, J. Griffin, B. Zlokovic, 2016, Arteriosclerosis, thrombosis, and vascular biology.

Physiological cerebrovascular remodeling in response to chronic mild hypoxia: A role for activated protein C

José A Fernández, J. Griffin, R. Milner, 2016, Experimental Neurology.

Thrombotic Stroke : Neuroprotective Therapy by Recombinant-Activated Protein C

José A Fernández, J. Griffin, B. Zlokovic, 2016 .

Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells

Hiroshi Deguchi, John H. Griffin, José A Fernández, 2009, Proceedings of the National Academy of Sciences.

Endotoxemia and sepsis mortality reduction by non-anticoagulant–activated protein C

Nigel Mackman, Edward J. Kerschen, John H. Griffin, 2007, The Journal of experimental medicine.

Activated Protein C Prevents Neuronal Apoptosis via Protease Activated Receptors 1 and 3

José A Fernández, J. Griffin, B. Zlokovic, 2004, Neuron.

Prognostic value of protein C concentrations in neutropenic patients at high risk of severe septic complications

José A Fernández, J. Helterbrand, J. Griffin, 2000, Critical care medicine.

Activation of protein C and hemodynamic recovery after coronary artery bypass surgery.

José A Fernández, J. Griffin, R. Lassila, 2007, The Journal of thoracic and cardiovascular surgery.

Activated protein C plasma levels in the fasting and postprandial states among patients with previous unprovoked venous thromboembolism.

José A Fernández, J. Hansen, S. Braekkan, 2012, Thrombosis research.

Lyso-Sulfatide Binds Factor Xa and Inhibits Thrombin Generation by the Prothrombinase Complex

José A Fernández, J. Griffin, Yajnavalka Banerjee, 2015, PloS one.

3K3A-Activated Protein C Protects the Blood-Brain Barrier and Neurons From Accelerated Ischemic Injury Caused by Pericyte Deficiency in Mice

José A Fernández, J. Griffin, B. Zlokovic, 2022, Frontiers in Neuroscience.

Acylcarnitines are anticoagulants that inhibit factor Xa and are reduced in venous thrombosis, based on metabolomics data.

José A Fernández, G. Siuzdak, J. Griffin, 2015, Blood.

Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity

José A Fernández, R. Deane, J. Griffin, 2009, The European journal of neuroscience.

Activated protein C inhibits tissue plasminogen activator–induced brain hemorrhage

José A Fernández, Dong Liu, M. Chopp, 2006, Nature Medicine.

Cytoprotective-selective activated protein C attenuates Pseudomonas aeruginosa-induced lung injury in mice.

José A Fernández, M. Cohen, J. Griffin, 2011, American journal of respiratory cell and molecular biology.

Apolipoprotein E Receptor 2 Mediates Activated Protein C–Induced Endothelial Akt Activation and Endothelial Barrier Stabilization

José A Fernández, J. Griffin, Xia V. Yang, 2016, Arteriosclerosis, thrombosis, and vascular biology.

Re-Evaluation of the Anticoagulant Properties of High-Density Lipoprotein—Brief Report

José A Fernández, J. Griffin, J. Witztum, 2015, Arteriosclerosis, thrombosis, and vascular biology.

Platelet protein S limits venous but not arterial thrombosis propensity by controlling coagulation in the thrombus.

José A Fernández, J. Griffin, Y. Matsumura, 2020, Blood.

Activated Protein C in the Cardioplegic Solution on a Porcine Model of Coronary Ischemia-Reperfusion has Deleterious Hemodynamic Effects

José A Fernández, J. Griffin, H. Repo, 2006, Cardiovascular Drugs and Therapy.

Human plasma phospholipid transfer protein specific activity is correlated with HDL size: implications for lipoprotein physiology.

José A Fernández, J. Griffin, J. Albers, 2009, Biochimica et biophysica acta.

Protein S Protects Neurons from Excitotoxic Injury by Activating the TAM Receptor Tyro3–Phosphatidylinositol 3-Kinase–Akt Pathway through Its Sex Hormone-Binding Globulin-Like Region

José A Fernández, J. Griffin, B. Zlokovic, 2010, The Journal of Neuroscience.

Activation of protein C during reperfusion in clinical liver transplantation

José A Fernández, J. Griffin, H. Repo, 2003, Transplantation.

Activated protein C preserves functional islet mass after intraportal transplantation: a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death.

José A Fernández, J. Contreras, J. Thompson, 2004, Diabetes.

PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke.

José A Fernández, J. Griffin, B. Zlokovic, 2018, Blood.

Serum amyloid A4 is a procoagulant apolipoprotein that it is elevated in venous thrombosis patients

José A Fernández, J. Griffin, H. Deguchi, 2019, Research and practice in thrombosis and haemostasis.

Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke.

José A Fernández, J. Griffin, José A. Fernández, 2002, Seminars in hematology.

Activated Protein C (APC) and 3K3A-APC-Induced Regression of Choroidal Neovascularization (CNV) Is Accompanied by Vascular Endothelial Growth Factor (VEGF) Reduction

José A Fernández, D. Weinberger, J. Griffin, 2021, Biomolecules.

Pharmacological targeting of the thrombomodulin–protein C pathway mitigates radiation toxicity

José A Fernández, A. Schambach, L. Fink, 2012, Nature Medicine.

Pharmacological targeting of the thrombomodulin – activated protein C pathway mitigates radiation toxicity

José A Fernández, A. Schambach, L. Fink, 2022 .

Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant.

José A Fernández, J. Griffin, Xia V. Yang, 2009, Blood.

Platelet factor 4 enhances generation of activated protein C in vitro and in vivo.

José A Fernández, J. Griffin, N. Key, 2003, Blood.

Oral anticoagulation reduces activated protein C less than protein C and other vitamin K-dependent clotting factors.

José A Fernández, J. Griffin, P. D. de Groot, 2002, Blood.

CSP ctivation of protein C and hemodynamic recovery after oronary artery bypass surgery

José A Fernández, J. Griffin, José A. Fernández, 2006 .

Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1

José A Fernández, J. Griffin, R. Schuepbach, 2009, Thrombosis and Haemostasis.

Activated Protein C Promotes Neovascularization and Neurogenesis in Postischemic Brain via Protease-Activated Receptor 1

José A Fernández, J. Griffin, B. Zlokovic, 2008, The Journal of Neuroscience.

Activated protein C promotes neuroprotection: mechanisms and translation to the clinic.

José A Fernández, J. Griffin, B. Zlokovic, 2016, Thrombosis research.

Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells.

Lee D. Hallagan, José A Fernández, R. Deane, 2009, The Journal of clinical investigation.

Functional recovery after embolic stroke in rodents by activated protein C

José A Fernández, M. Chopp, J. Griffin, 2005, Annals of neurology.

Anti-Inflammatory, Antithrombotic, and Neuroprotective Effects of Activated Protein C in a Murine Model of Focal Ischemic Stroke

Berislav V. Zlokovic, John H. Griffin, José A Fernández, 2001, Circulation.

Activated protein C and PAR1‐derived and PAR3‐derived peptides are anti‐inflammatory by suppressing macrophage NLRP3 inflammasomes

Laura D. Healy, José A Fernández, J. Griffin, 2020, Journal of thrombosis and haemostasis : JTH.

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Extensive Venous and Arterial Thrombosis Associated With an Inhibitor to Activated Protein C

H. Halkin, J. Griffin, U. Martinowitz, 2016 .

Graft protein C entrapment is associated with reduced phagocyte activation during reperfusion in human liver transplantation

José A Fernández, J. Griffin, K. Höckerstedt, 2006, Critical care medicine.

Activated protein C and inflammation in human myocardium after heart surgery

José A Fernández, J. Griffin, J. A. Fernandez, 2001, American journal of hematology.

Analysis of the urinary metabolic profiles in irradiated rats treated with Activated Protein C (APC), a potential mitigator of radiation toxicity

José A Fernández, M. Boerma, J. Griffin, 2023, International journal of radiation biology.

Activated protein C anticoagulant activity is enhanced by skeletal muscle myosin

José A Fernández, J. Griffin, H. Deguchi, 2019, Haematologica.

Exacerbated venous thromboembolism in mice carrying a protein S K196E mutation.

José A Fernández, J. Griffin, T. Miyata, 2015, Blood.

Protein C pathway impairment in nonsymptomatic cigarette smokers.

José A Fernández, J. Griffin, A. Gruber, 2002, Blood cells, molecules & diseases.

An optimized method for the isolation of urinary extracellular vesicles for molecular phenotyping: detection of biomarkers for radiation exposure

José A Fernández, M. Boerma, J. Griffin, 2022, bioRxiv.

Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C

Mikko T. Huuskonen, José A Fernández, J. Griffin, 2021, The Journal of experimental medicine.

The promise of protein C.

José A Fernández, J. Griffin, B. Zlokovic, 2006, Blood cells, molecules & diseases.

Inhibition of thrombin generation in human plasma by phospholipid transfer protein

José A Fernández, J. Griffin, J. Albers, 2015, Thrombosis Journal.