R. J. Kluin

发表

Effect of HIPEC according to HRD/BRCAwt genomic profile in stage III ovarian cancer: Results from the phase III OVHIPEC trial

H. Horlings, P. V. van Dam, P. Nederlof, 2022, International journal of cancer.

Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial

H. Horlings, L. Wessels, T. Schumacher, 2019, Nature Medicine.

Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer

R. Bernards, S. Chin, C. Caldas, 2016, Scientific Reports.

Publisher Correction: Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial

H. Horlings, T. Schumacher, L. Wessels, 2019, Nature Medicine.

Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial

H. Horlings, T. Schumacher, L. Wessels, 2019, Nature Medicine.

The impact of monosomies, trisomies and segmental aneuploidies on chromosomal stability

R. Medema, P. Lansdorp, Michael Schubert, 2022, PloS one.

High-throughput identification of antigen-specific TCRs by TCR gene capture

T. Schumacher, D. Chudakov, C. Blank, 2013, Nature Medicine.

Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers

T. Schumacher, G. Kenter, B. Nelson, 2018, Nature Medicine.

Identification of recurrent FGFR3 fusion genes in lung cancer through kinome‐centred RNA sequencing

R. Bernards, A. Brazma, H. Horlings, 2013, The Journal of pathology.

BRAFV600E Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts

D. Adams, T. Schumacher, U. McDermott, 2016, Cell reports.

BRCA1‐like signature in triple negative breast cancer: Molecular and clinical characterization reveals subgroups with therapeutic potential

Carlos Caldas, Magali Michaut, René Bernards, 2015, Molecular oncology.

Integrative Kinome Profiling Identifies mTORC1/2 Inhibition as Treatment Strategy in Ovarian Clear Cell Carcinoma

R. Bernards, J. Brenton, A. V. D. Van Der Zee, 2018, Clinical Cancer Research.

Ovarian Cancer–Specific BRCA-like Copy-Number Aberration Classifiers Detect Mutations Associated with Homologous Recombination Deficiency in the AGO-TR1 Trial

D. Dietrich, L. Wessels, P. Nederlof, 2021, Clinical Cancer Research.

A regression model for estimating DNA copy number applied to capture sequencing data

Lodewyk F. A. Wessels, Ian J. Majewski, Zheng Xue, 2012, Bioinform..

XenofilteR: computational deconvolution of mouse and human reads in tumor xenograft sequence data

D. Adams, U. McDermott, V. Iyer, 2018, BMC Bioinformatics.

Adjuvant Capecitabine-Containing Chemotherapy Benefit and Homologous Recombination Deficiency Status Among Early-Stage TNBC Patients in the FinXX trial

M. Hauptmann, P. Nederlof, S. Linn, 2020 .

Resource BRAFV 600 E Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts Graphical

D. Adams, T. Schumacher, U. McDermott, 2022 .

Adjuvant capecitabine-containing chemotherapy benefit and homologous recombination deficiency in early-stage triple-negative breast cancer patients

M. Hauptmann, P. Nederlof, S. Linn, 2022, British Journal of Cancer.

Role of variant allele fraction and rare SNP filtering to improve cellular DNA repair endpoint association

Michiel W M van den Brekel, Conchita Vens, Lodewyk F A Wessels, 2018, PloS one.

Fanconi anemia and homologous recombination gene variants are associated with functional DNA repair defects in vitro and poor outcome in patients with advanced head and neck squamous cell carcinoma

Lodewyk F.A. Wessels, Conchita Vens, Arno Velds, 2018, Oncotarget.

Endonuclease FEN1 Coregulates ERα Activity and Provides a Novel Drug Interface in Tamoxifen-Resistant Breast Cancer

David M. Wilson, Simak Ali, M. Periyasamy, 2020, Cancer Research.

Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers

T. Schumacher, G. Kenter, B. Nelson, 2018, Nature Medicine.

An α‐E‐catenin (CTNNA1) mutation in hereditary diffuse gastric cancer

R. Bernards, D. Jong, D. Huntsman, 2013, The Journal of pathology.

Kinome capture sequencing of high-grade serous ovarian carcinoma reveals novel mutations in the JAK3 gene

N. Rosenfeld, R. Bernards, M. Jimenez-Linan, 2020, PloS one.

Predictive Immune-Checkpoint Blockade Classifiers Identify Tumors Responding to Inhibition of PD-1 and/or CTLA-4

P. Ross-Macdonald, D. Adams, O. Krijgsman, 2021, Clinical Cancer Research.

PREDICTIVE IMMUNE CHECKPOINT BLOCKADE CLASSIFIERS DISTINGUISHING MONO- VERSUS COMBINATION THERAPY REQUIREMENT

P. Ross-Macdonald, D. Adams, O. Krijgsman, 2020, bioRxiv.

A chromatin-associated regulator of RNA Polymerase III assembly at tRNA genes revealed by locus-specific proteomics

Teun van den Brand, T. Lenstra, K. Verstrepen, 2023, bioRxiv.

Drug-induced epigenomic plasticity reprograms circadian rhythm regulation to drive prostate cancer towards androgen-independence

H. G. van der Poel, A. Zoubeidi, T. Severson, 2021, medRxiv.

Integrative Modeling Identifies Key Determinants of Inhibitor Sensitivity in Breast Cancer Cell Lines.

Bram Thijssen, Roderick L Beijersbergen, Lodewyk F A Wessels, 2018, Cancer research.

Role of variant allele fraction and rare SNP filtering to improve cellular DNA repair endpoint association

L. Wessels, M. Verheij, C. Vens, 2018, PloS one.

XenofilteR: computational deconvolution of mouse and human reads in tumor xenograft sequence data

David J. Adams, Jos Jonkers, Ji-Ying Song, 2018, BMC Bioinformatics.

Dynamic changes in clonal architecture during disease progression in follicular lymphoma

R. Bernards, D. de Jong, W. Alexander, 2017, bioRxiv.

Comparison of human recombinant protein coatings and fibroblast-ECM to Matrigel for induced pluripotent stem cell culture and renal podocyte differentiation.

A. Wilmes, R. Kluin, C. Murphy, 2022, ALTEX.

Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma

S. Vegna, Daan J. Kloosterman, R. J. Kluin, 2024, Nature communications.

Long-term outcomes of young, node-negative, chemotherapy-naïve, triple-negative breast cancer patients according to BRCA1 status

P. V. van Diest, A. Broeks, P. Nederlof, 2024, BMC medicine.

Locus-specific proteome decoding reveals Fpt1 as a chromatin-associated negative regulator of RNA polymerase III assembly.

T. Lenstra, K. Verstrepen, R. Beijersbergen, 2023, Molecular cell.

Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer

R. Bernards, S. Chin, C. Caldas, 2016, Scientific Reports.