L. Deng

发表

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

Roger A. Jones, M. Ascano, T. Tuschl, 2013, Cell.

Intratumoral delivery of inactivated modified vaccinia virus Ankara (iMVA) induces systemic antitumor immunity via STING and Batf3-dependent dendritic cells

J. Wolchok, S. Shuman, T. Merghoub, 2017, Science Immunology.

An ATPase Component of the Transcription Elongation Complex Is Required for Factor-dependent Transcription Termination by Vaccinia RNA Polymerase*

S. Shuman, Liang Deng, L. Deng, 1996, The Journal of Biological Chemistry.

Factor-dependent Release of Nascent RNA by Ternary Complexes of Vaccinia RNA Polymerase*

S. Shuman, Liang Deng, J. Hagler, 1996, The Journal of Biological Chemistry.

Thalidomide inhibits tumor necrosis factor-alpha production and antigen presentation by Langerhans cells.

Liang Deng, R. Granstein, W. Ding, 2003, The Journal of investigative dermatology.

Transcription Termination by Vaccinia RNA Polymerase Entails Recognition of Specific Phosphates in the Nascent RNA*

S. Shuman, L. Deng, 1997, The Journal of Biological Chemistry.

Lung type II alveolar epithelial cells collaborate with CCR2+ inflammatory monocytes in host defense against poxvirus infection

Joseph M. Luna, P. Dai, Liang Deng, 2020, Nature Communications.

Innate Immune Response of Human Plasmacytoid Dendritic Cells to Poxvirus Infection Is Subverted by Vaccinia E3 via Its Z-DNA/RNA Binding Domain

G. McFadden, A. Houghton, Jia Liu, 2012, PloS one.

Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert microenvironment and is sensitized by immunogenic viruses

Ekta Khurana, C. Antonescu, D. Zheng, 2022, The Journal of clinical investigation.

Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert tumor microenvironment and confers resistance to immunotherapy

Ekta Khurana, C. Antonescu, D. Zheng, 2022, bioRxiv.

White paper on microbial anti-cancer therapy and prevention

Shibin Zhou, R. Vile, G. McFadden, 2018, Journal of Immunotherapy for Cancer.

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two

Manish R. Patel, Charles J. Vaske, Joe Y. Chang, 2016, Journal for Immunotherapy of Cancer.

Vaccinia Virus Infection Attenuates Innate Immune Responses and Antigen Presentation by Epidermal Dendritic Cells

S. Shuman, P. Dai, Liang Deng, 2006, Journal of Virology.

Abstract LB-306: Oncolytic vaccinia virus expressing immune checkpoint blockade antibody as cancer immunotherapeutics

J. Wolchok, S. Shuman, T. Merghoub, 2018, Immunology.

Elucidating mechanisms of antitumor immunity mediated by live oncolytic vaccinia and heat-inactivated vaccinia

J. Wolchok, T. Merghoub, P. Dai, 2021, Journal for ImmunoTherapy of Cancer.

A new checkpoint against ferroptosis

Xuejun Jiang, Deguang Liang, L. Deng, 2019, Cell Research.

In vivo tumor immune microenvironment phenotypes correlate with inflammation and vasculature to predict immunotherapy response

A. Marghoob, M. Rajadhyaksha, A. Santella, 2022, Nature Communications.

Heat-inactivated modified vaccinia virus Ankara boosts Th1 cellular and humoral immunity as a vaccine adjuvant

T. Tuschl, J. Wolchok, T. Merghoub, 2022, npj Vaccines.

Altered cutaneous immune parameters in transgenic mice overexpressing viral IL-10 in the epidermis.

J. Bluestone, S. Beissert, G. Murphy, 2003, The Journal of clinical investigation.

Modified Vaccinia Virus Ankara Triggers Type I IFN Production in Murine Conventional Dendritic Cells via a cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway

Zhijian J. Chen, S. Shuman, T. Merghoub, 2014, PLoS pathogens.

Myxoma Virus Induces Type I Interferon Production in Murine Plasmacytoid Dendritic Cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-Dependent Pathway

G. McFadden, A. Houghton, S. Shuman, 2011, Journal of Virology.

Vaccinia E5 is a major inhibitor of the DNA sensor cGAS

Zhijian J. Chen, A. Ordureau, R. Hendrickson, 2021, bioRxiv.

Myxoma Virus Induces Type I Interferon Production in Murine Plasmacytoid Dendritic Cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-Dependent Pathway

G. McFadden, A. Houghton, S. Shuman, 2011, Journal of Virology.

Identification of Novel Antipoxviral Agents: Mitoxantrone Inhibits Vaccinia Virus Replication by Blocking Virion Assembly

D. Smee, S. Shuman, Hakim Djaballah, 2007, Journal of Virology.

IL-12-expressing highly immunogenic recombinant modified vaccinia virus Ankara reprograms tumor-infiltrating myeloid cells to overcome immune resistance

J. Wolchok, Ming O. Li, T. Merghoub, 2022, bioRxiv.

Cellular-level phenotyping of tumor-immune microenvironment (TiME) in patients in vivo reveals distinct inflammation and endothelial anergy signatures

A. Marghoob, A. Halpern, M. Rajadhyaksha, 2021, bioRxiv.

Phenotyping the human tumor-immune microenvironment (TiME) in vivo by cellular-level optical imaging reveals unique combination phenotypes with variable inflammation and endothelial anergy

A. Marghoob, A. Halpern, M. Rajadhyaksha, 2021 .

Identification of novel antipoxviral agents : Mitoxantrone inhibits vaccinia virus 10 replication by blocking virion assembly 11 12 13 14

D. Smee, S. Shuman, Hakim Djaballah, 2007 .

Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA

M. Ascano, T. Tuschl, D. Patel, 2014, Cell reports.

Binding-Pocket and Lid-Regi on Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA Graphical

M. Ascano, T. Tuschl, D. Patel, 2014 .

Vaccinia Virus Subverts a Mitochondrial Antiviral Signaling Protein-Dependent Innate Immune Response in Keratinocytes through Its Double-Stranded RNA Binding Protein, E3

A. Houghton, Zhijian J. Chen, S. Shuman, 2008, Journal of Virology.

Lung type II alveolar epithelial cells collaborate with CCR2+ inflammatory monocytes in host defense against an acute vaccinia infection in the lungs

Joseph M. Luna, P. Dai, Liang Deng, 2020, bioRxiv.

Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert microenvironment and is sensitized by immunogenic therapeutic viruses

Yu Chen, Ekta Khurana, D. Zheng, 2022 .

OX40L-expressing recombinant modified vaccinia virus Ankara induces potent antitumor immunity via reprogramming Tregs.

J. Wolchok, T. Merghoub, Wei Yan, 2023, Journal of Experimental Medicine.

Intratumoral delivery of engineered recombinant modified vaccinia virus Ankara expressing Flt3L and OX40L generates potent antitumor immunity through activating the cGAS/STING pathway and depleting tumor-infiltrating regulatory T cells

J. Wolchok, A. Rossi, T. Merghoub, 2021, bioRxiv.

A novel role for the apoptosis inhibitor ARC in suppressing TNFα-induced regulated necrosis

G. Kung, R. Kitsis, P. Dai, 2014, Cell Death and Differentiation.

Heat-inactivated modified vaccinia virus Ankara boosts Th1-biased cellular and humoral immune responses as a vaccine adjuvant by activating the STING-mediated cytosolic DNA-sensing pathway

T. Tuschl, J. Wolchok, T. Merghoub, 2021, bioRxiv.

IRF5/IRF7-, and IFNAR-Dependent Pathway Dendritic Cells via a TLR9/MyD88-, Production in Murine Plasmacytoid Myxoma Virus Induces Type I Interferon

T. Merghoub, P. Pitha, P. Dai, 2011 .

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two

Charles J. Vaske, Joe Y. Chang, Scott R. Presnell, 2016, Journal for ImmunoTherapy of Cancer.

Combination of imiquimod with cryotherapy in the treatment of penile intraepithelial neoplasia

M. Lacouture, G. Nguyen, L. Deng, 2017, JAAD case reports.