J. Leahy

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An end-game strategy for construction of the G-H-I rings of penitrem D, A tremorgenic indole alkaloid

Amos B. Smith, J. W. Leahy, M. Ohta, 1993 .

Structural and Mechanistic Analysis of Drosophila melanogaster Agmatine N-Acetyltransferase, an Enzyme that Catalyzes the Formation of N-Acetylagmatine

Yu Chen, D. Merkler, Xiujun Zhang, 2017, Scientific Reports.

Alkyne modified purines for assessment of activation of Plasmodium vivax hypnozoites and growth of pre-erythrocytic and erythrocytic stages in Plasmodium spp.

M. Cassera, E. F. Merino, D. Kyle, 2022, International journal for parasitology.

Targeting the FKBP51/GR/Hsp90 Complex to Identify Functionally Relevant Treatments for Depression and PTSD.

J. Buchner, D. Rutz, J. Koren, 2018, ACS chemical biology.

A Unified Total Synthesis of the Immunomodulators (−)-Rapamycin and (−)-27-Demethoxyrapamycin: Construction of the C(21−42) Perimeters

S. Condon, Amos B. Smith, J. Mccauley, 1997 .

A Unified Total Synthesis of the Immunomodulators (−)-Rapamycin and (−)-27-Demethoxyrapamycin: Assembly of the Common C(1−20) Perimeter and Final Elaboration

S. Condon, Amos B. Smith, J. Mccauley, 1997 .

Total Synthesis of Rapamycin and Demethoxyrapamycin

S. Condon, Amos B. Smith, J. Mccauley, 1995 .

Characterization of Arylalkylamine N-Acyltransferase from Tribolium castaneum: An investigation into a potential next-generation insecticide target.

Yu Chen, D. Merkler, J. W. Leahy, 2020, ACS chemical biology.

Medicinal Chemistry and Lead Optimization of Marine Natural Products

J. W. Leahy, J. Leahy, 2015 .

Discovery of a novel class of potent and orally bioavailable sphingosine 1-phosphate receptor 1 antagonists.

Aaron Shipway, L. Mattheakis, J. Nuss, 2012, Journal of medicinal chemistry.

SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors.

J. Martini, J. Nuss, Wentao Zhang, 2012, Bioorganic & medicinal chemistry letters.

Identification and Characterization of Novel Bronchodilator Agonists Acting at Human Airway Smooth Muscle Cell TAS2R5.

S. Liggett, Donghwa Kim, S. An, 2020, ACS pharmacology & translational science.

Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR).

K. Yamaguchi, J. Nuss, J. Woolfrey, 2013, Journal of medicinal chemistry.

Synthesis and Activity of a New Series of Antileishmanial Agents.

D. Kyle, Benjamin J. Eduful, A. Azhari, 2017, ACS medicinal chemistry letters.

Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba

P. Myler, D. Kyle, I. Phan, 2020, bioRxiv.

Design, synthesis and in vitro evaluation of potent, novel, small molecule inhibitors of plasminogen activator inhibitor-1.

P. Charlton, N. Vicker, J. Golec, 2002, Bioorganic & medicinal chemistry letters.

Discovery of a novel series of potent and orally bioavailable phosphoinositide 3-kinase γ inhibitors.

Charles R. Holst, J. Nuss, Xiang Wu, 2012, Journal of medicinal chemistry.

Alkyne modified purines for assessing activation of Plasmodium vivax hypnozoites and growth of pre-erythrocytic and erythrocytic stages in Plasmodium spp

M. Cassera, E. F. Merino, D. Kyle, 2021, bioRxiv.

Enantioselective Total Synthesis of Cannabinoids-A Route for Analogue Development.

J. Jacobson, J. W. Leahy, Z. Shultz, 2018, Organic letters.

The first design and synthesis of a steroidal peptidomimetic. The potential value of peptidomimetics in elucidating the bioactive conformation of peptide ligands

W. Shakespeare, R. Hirschmann, Amos B. Smith, 1992 .

The Asymmetric Baylis−Hillman Reaction

J. W. Leahy, L. Brzezinski, Sara Rafel, 1997 .

The versatile steroid nucleus: Design and synthesis of a peptidomimetic employing this novel scaffold.

W. Shakespeare, R. Hirschmann, Amos B. Smith, 1993 .

The asymmetric Baylis-Hillman reaction as a template in organic synthesis

J. W. Leahy, L. Brzezinski, Sara Rafel, 1997 .

Rapamycin synthetic studies. 1. Construction of the C(27)-C(42) subunit

S. Condon, Amos B. Smith, J. Mccauley, 1994 .

Enantioselective total synthesis of the antitumor macrolide rhizoxin D.

D. Provencal, Cristina Gardelli, J. W. Leahy, 2003, The Journal of organic chemistry.

Inactivation of peptidylglycine α-hydroxylating monooxygenase by cinnamic acid analogs

Edward W. Lowe, Neil R. McIntyre, D. Merkler, 2016, Journal of enzyme inhibition and medicinal chemistry.

Enantiospecific Total Synthesis of the Potent Antitumor Macrolides Cryptophycins 1 and 8.

J. W. Leahy, K. Gardinier, J. Leahy, 1997, The Journal of organic chemistry.

A synthetic approach to the phorboxazoles – A strategy for the synthesis of the C1–C19 polyketide fragment

D. C. Carroll, J. Leahy, K. E. McElhone, 2018 .

A synthetic approach to the phorboxazoles—synthesis of the exocyclic fragment

J. W. Leahy, L. Brzezinski, J. Leahy, 2016 .

Synthesis of the phorboxazoles—potent, architecturally novel marine natural products

Z. Shultz, J. Leahy, 2016, The Journal of Antibiotics.

Absolute Configuration of Phorboxazoles A and B from the Marine Sponge Phorbas sp. 1. Macrolide and Hemiketal Rings

T. Molinski, J. W. Leahy, P. A. Searle, 1996 .

Rhizoxin synthetic studies. 2. Synthesis of the left hand [C(10) to C(19)] and polyene fragments

D. Provencal, Cristina Gardelli, J. Lafontaine, 1995 .

Benzothiazole Substitution Analogs of Rhodacyanine Hsp70 Inhibitors Modulate Tau Accumulation.

C. Dickey, S. Hill, April L Darling, 2023, ACS chemical biology.

Structural and Mechanistic Analysis of Drosophila melanogaster Agmatine N-Acetyltransferase, an Enzyme that Catalyzes the Formation of N-Acetylagmatine

Yu Chen, D. Merkler, Xiujun Zhang, 2017, Scientific Reports.

Binding-based proteomic profiling and the fatty acid amides

D. Merkler, J. W. Leahy, J. Leahy, 2018, Trends in research.

An Unexpected Rate AccelerationPractical Improvements in the Baylis−Hillman Reaction†

J. W. Leahy, Sara Rafel, J. Leahy, 1997 .

Rhizoxin synthetic studies. 1. Synthesis of the right hand [C(1) to C(9)]portion via a “pinwheel” approach

J. W. Leahy, J. Lafontaine, J. Leahy, 1995 .

Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries.

D. Kyle, M. Giulianotti, R. Houghten, 2017, ACS medicinal chemistry letters.