Robert W Harrison

发表

Sparse Representation for HIV-1 Protease Drug Resistance Prediction

Xiaxia Yu, Irene T Weber, Robert W Harrison, 2013, SDM.

Structure based drug design for HIV protease: from molecular modeling to cheminformatics.

Irene T Weber, Robert W Harrison, Patra Volarath, 2007, Current topics in medicinal chemistry.

Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease.

Irene T Weber, Robert W Harrison, Yuan-Fang Wang, 2007, Journal of medicinal chemistry.

Covalent reaction intermediate revealed in crystal structure of the Geobacillus stearothermophilus carboxylesterase Est30.

Irene T Weber, Robert W Harrison, Chung-Dar Lu, 2004, Journal of molecular biology.

Atomic resolution crystal structures of HIV‐1 protease and mutants V82A and I84V with saquinavir

Irene T Weber, Robert W Harrison, Yuan-Fang Wang, 2007, Proteins.

Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir.

Irene T Weber, Robert W Harrison, Arun K. Ghosh, 2008, Journal of molecular biology.

Effect of sequence polymorphism and drug resistance on two HIV-1 Gag processing sites.

Irene T Weber, Robert W Harrison, Péter Bagossi, 2002, European journal of biochemistry.

Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114.

Irene T Weber, Robert W Harrison, Arun K. Ghosh, 2006, Journal of molecular biology.

Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 Å resolution crystal structures of HIV‐1 protease mutants with substrate analogs

Irene T Weber, Robert W Harrison, Yuan-Fang Wang, 2005, The FEBS journal.

Mechanism of drug resistance revealed by the crystal structure of the unliganded HIV-1 protease with F53L mutation.

Irene T Weber, Robert W Harrison, Yuan-Fang Wang, 2006, Journal of molecular biology.

Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.

Irene T Weber, Robert W Harrison, Yuan-Fang Wang, 2005, Journal of molecular biology.

Geometric criteria of hydrogen bonds in proteins and identification of "bifurcated" hydrogen bonds.

Irene T Weber, Robert W Harrison, I. Weber, 2002, Protein engineering.

Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site.

Irene T Weber, Robert W Harrison, Yuan-Fang Wang, 2004, European journal of biochemistry.

Analysis of protein structures reveals regions of rare backbone conformation at functional sites

Irene T Weber, Robert W Harrison, I. Weber, 2003, Proteins.

Combining mutations in HIV‐1 protease to understand mechanisms of resistance

Irene T Weber, Robert W Harrison, Yuan-Fang Wang, 2002, Proteins.

High resolution crystal structures of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) active against multi-drug-resistant clinical strains.

Irene T Weber, Robert W Harrison, Yuan-Fang Wang, 2004, Journal of molecular biology.

Close pairs of carboxylates: a possibility of multicenter hydrogen bonds in proteins.

Irene T Weber, Robert W Harrison, I. Weber, 2003, Protein engineering.

Molecular dynamics simulations of 14 HIV protease mutants in complexes with indinavir

Irene T Weber, Robert W Harrison, I. Weber, 2004, Journal of molecular modeling.