C. O'connor

发表

Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors.

C. Dann, G. Garcia, X. Bao, 2021, Bioorganic & medicinal chemistry.

Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment

L. Matherly, Z. Hou, L. Polin, 2022, Scientific Reports.

Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier.

L. Matherly, F. Islam, Z. Hou, 2020, Bioorganic & medicinal chemistry.

Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism

L. Matherly, M. Hüttemann, Z. Hou, 2019, Molecular Pharmacology.

Folate transporter dynamics and therapy with classic and tumor-targeted antifolates

L. Matherly, Z. Hou, A. Gangjee, 2021, Scientific Reports.

Design, synthesis and evaluation of a potent substrate analog inhibitor identified by scanning Ala/Phe mutagenesis, mimicking substrate co-evolution, against multidrug-resistant HIV-1 protease.

M. Spaller, Zhigang Liu, I. Kovari, 2013, Biochemical and biophysical research communications.

Design , synthesis and evaluation of a potent substrate-analog peptide-inhibitor identified by scanning Ala / Phe chemical mutagenesis

M. Spaller, Zhigang Liu, I. Kovari, 2013 .

Novel Pyrrolo[3,2-d]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy

J. Rabinowitz, C. Dann, X. Bao, 2019, Molecular Cancer Therapeutics.

Dual Targeting of Epithelial Ovarian Cancer Via Folate Receptor α and the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]pyrimidine Antifolates

L. Matherly, Z. Hou, L. Polin, 2017, Molecular Cancer Therapeutics.

Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.

C. Dann, H. Xu, L. Matherly, 2016, Journal of medicinal chemistry.

6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors.

C. Dann, L. Matherly, Z. Hou, 2015, Journal of medicinal chemistry.

Microsoft Word-SHMT2 Pharmacodynamics Manuscript final 10-7-19 FINAL

L. Matherly, M. Hüttemann, Z. Hou, 2019 .

Fluorine-Substituted Pyrrolo[2,3- d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.

L. Matherly, Z. Hou, L. Polin, 2018, Journal of medicinal chemistry.

Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3- d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis.

L. Matherly, Z. Hou, L. Polin, 2018, Journal of medicinal chemistry.

Generation and characterization of the protein-induced pluripotent stem (piPS) cells

C. O'connor, 2012 .

Discovery of amide-bridged pyrrolo[2,3-d]pyrimidines as tumor targeted classical antifolates with selective uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis.

L. Matherly, Z. Hou, A. Gangjee, 2019, Bioorganic & medicinal chemistry.

Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria

L. Matherly, Z. Hou, A. Gangjee, 2023, Journal of medicinal chemistry.

Regulation of differential proton-coupled folate transporter gene expression in human tumors: transactivation by KLF15 with NRF-1 and the role of Sp1.

L. Matherly, Z. Hou, A. Gangjee, 2019, The Biochemical journal.