B. Nuesslein‐Hildesheim

发表

FTY720 reactivates cryptococcal granulomas in mice through S1P receptor 3 on macrophages.

M. Del Poeta, B. Nuesslein-Hildesheim, Arielle M. Bryan, 2020, The Journal of clinical investigation.

Leptin does not reduce body fat content but augments cold defense abilities in thermoneutrally reared rat pups

B. Nuesslein-Hildesheim, O. Stehling, I. Schmidt, 1997, Pflügers Archiv.

Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.

E. G. Funhoff, A. Vulpetti, B. Nuesslein-Hildesheim, 2020, Journal of medicinal chemistry.

The selective sphingosine 1-phosphate receptor modulator BAF312 redirects lymphocyte distribution and has species-specific effects on heart rate

N. Gray, T. Sing, B. Nuesslein-Hildesheim, 2012, British journal of pharmacology.

MSG lesions decrease body mass of suckling-age rats by attenuating circadian decreases of energy expenditure.

B. Nuesslein-Hildesheim, T. Hübschle, C. Schoelch, 2002, American journal of physiology. Endocrinology and metabolism.

Monosodium-glutamate lesions decrease body mass of suckling-age rats by attenuating the circadian decreases of energy expenditure

B. Nuesslein-Hildesheim, T. Hübschle, C. Schoelch, 2002 .

Siponimod therapy implicates Th17 cells in a preclinical model of subpial cortical injury.

J. Gommerman, B. Nuesslein-Hildesheim, L. Ward, 2019, JCI insight.

Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator.

N. Gray, S. Lefebvre, Jianwei Che, 2013, ACS medicinal chemistry letters.

A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model.

N. Gray, S. Lefebvre, B. Nuesslein-Hildesheim, 2006, Chemistry & biology.

Pyrazole derived from (+)-3-carene; a novel potent, selective scaffold for sphingosine-1-phosphate (S1P(1)) receptor agonists.

B. Nuesslein-Hildesheim, M. Streiff, F. Zécri, 2010, Bioorganic & medicinal chemistry letters.

Discovery and SAR of potent, orally available and brain-penetrable 5,6-dihydro-4H-3-thia-1-aza-benzo[e]azulen- and 4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen derivatives as neuropeptide Y Y5 receptor antagonists.

S. Whitebread, B. Nuesslein-Hildesheim, M. Gerspacher, 2004, Bioorganic & medicinal chemistry letters.

Pronounced juvenile circadian core temperature rhythms exist in several strains of rats but not in rabbits

B. Nuesslein-Hildesheim, K. Imai-Matsumura, I. Schmidt, 2004, Journal of Comparative Physiology B.

Combination of non-hypotensive doses of valsartan and enalapril improves survival of spontaneously hypertensive rats with endothelial dysfunction

P. Bruneval, B. Nuesslein-Hildesheim, J. Clozel, 2000, Journal of the renin-angiotensin-aldosterone system : JRAAS.

Leptin selectively increases energy expenditure of food-restricted lean mice

I. Schmidt, K. Schwarzer, H. Döring, 1998, International Journal of Obesity.

Strongly reduced alloreactivity and long‐term survival times of cardiac allografts in Vav1‐ and Vav1/Vav2‐knockout mice

B. Nuesslein-Hildesheim, R. Morris, G. Wieczorek, 2007, Transplant international : official journal of the European Society for Organ Transplantation.

AUY954, a selective S1P1 modulator, prevents experimental autoimmune neuritis

B. Nuesslein-Hildesheim, H. Schluesener, D. Leppert, 2009, Journal of Neuroimmunology.

The leptin receptor mediates apparent autocrine regulation of leptin gene expression.

T. Kowalski, M. Nicolson, R. Leibel, 1997, Biochemical and biophysical research communications.

Preclinical characterization of the Toll-like receptor 7/8 antagonist MHV370 for lupus therapy

T. Junt, P. Loetscher, E. Ferrero, 2023, Cell reports. Medicine.

Deficiency of MALT1 Paracaspase Activity Results in Unbalanced Regulatory and Effector T and B Cell Responses Leading to Multiorgan Inflammation

T. Mak, K. McCoy, D. Patel, 2015, The Journal of Immunology.

Effector T and B Cell Responses Leading to Results in Unbalanced Regulatory and Deficiency of MALT1 Paracaspase Activity

T. Mak, K. McCoy, D. Patel, 2015 .

Modulation of T cell homeostasis and alloreactivity under continuous FTY720 exposure.

Matthias Mueller, B. Nuesslein-Hildesheim, V. Brinkmann, 2008, International immunology.

The circadian cycle of mPER clock gene products in the suprachiasmatic nucleus of the Siberian hamster encodes both daily and seasonal time

E. Maywood, M. Hastings, J. O'Brien, 2000, The European journal of neuroscience.

Norepinephrine-Induced Phase Shifts of the Juvenile Circadian Core Temperature Rhythm in Rat Pups

B. Nuesslein-Hildesheim, I. Schmidt, B. Nuesslein‐Hildesheim, 1994 .

Leptin responsiveness and gene dosage for leptin receptor mutation (fa) in newborn rats.

B. Nuesslein-Hildesheim, G. Preibisch, I. Schmidt, 1999, The American journal of physiology.

A Sphingosine-1-Phosphate Receptor 1-Directed Agonist Reduces Central Nervous System Inflammation in a Plasmacytoid Dendritic Cell-Dependent Manner

M. Ostrowski, J. Schwartz, J. Gommerman, 2012, The Journal of Immunology.

Mutation in the leptin receptor (Leprfa) causes fat-storage-independent hyperleptinaemia in neonatal rats

R. Leibel, I. Schmidt, Y. Zhang, 1999, Pflügers Archiv.

Partial Deficiency of Sphingosine-1-Phosphate Lyase Confers Protection in Experimental Autoimmune Encephalomyelitis

Matthias Mueller, B. Nuesslein-Hildesheim, C. Beerli, 2013, PloS one.

Remibrutinib (LOU064) inhibits neuroinflammation driven by B cells and myeloid cells in preclinical models of multiple sclerosis

E. Ferrero, B. Cenni, Joëlle Rubert, 2023, Journal of Neuroinflammation.

Dendritic Cell-Dependent Manner System Inflammation in a Plasmacytoid 1-Directed Agonist Reduces Central Nervous A Sphingosine-1-Phosphate Receptor

J. Schwartz, J. Gommerman, O. Rojas, 2012 .