Frank Pui-Ling Lai

发表

Whole-genome analysis of noncoding genetic variations identifies multiscale regulatory element perturbations associated with Hirschsprung disease

Kevin Y. Yip, Alexander Xi Fu, P. Sham, 2020, bioRxiv.

Identification of Genes Associated With Hirschsprung Disease, Based on Whole-Genome Sequence Analysis, and Potential Effects on Enteric Nervous System Development.

Kevin Y. Yip, Alexander Xi Fu, P. Sham, 2018, Gastroenterology.

Identification of GLI Mutations in Patients With Hirschsprung Disease That Disrupt Enteric Nervous System Development in Mice.

P. Tam, H. Gui, C. Hui, 2015, Gastroenterology.

Organoid cultures for cancer modeling.

S. Leung, A. S. Chan, Frank Pui-Ling Lai, 2023, Cell stem cell.

Ciliary protein Kif7 regulates Gli and Ezh2 for initiating the neuronal differentiation of enteric neural crest cells during development

P. Sham, C. Hui, Kathy Nga-Chu Lui, 2021, Science advances.

Correction of Hirschsprung-Associated Mutations in Human Induced Pluripotent Stem Cells Via Clustered Regularly Interspaced Short Palindromic Repeats/Cas9, Restores Neural Crest Cell Function.

P. Tam, H. Tse, F. P. Lai, 2017, Gastroenterology.

Organoid models of breathing disorders reveal patterning defect of hindbrain neurons caused by PHOX2B-PARMs

Kathy Nga-Chu Lui, Sin-Ting Lau, Zhixin Li, 2023, Stem cell reports.

Transcriptomics of Hirschsprung disease patient-derived enteric neural crest cells reveals a role for oxidative phosphorylation

P. Sham, C. Hui, Kathy Nga-Chu Lui, 2023, Nature communications.

Activation of Hedgehog Signaling Promotes Development of Mouse and Human Enteric Neural Crest Cells, Based on single-cell Transcriptome Analyses.

G. Pan, C. Hui, Maxime M Mahe, 2019, Gastroenterology.

Correction of Hirschsprung-Associated Mutations in Human Induced Pluripotent Stem Cells Via Clustered Regularly Interspaced Short Palindromic Repeats/Cas9, Restores Neural Crest Cell Function.

P. Tam, H. Tse, Sin-Ting Lau, 2017, Gastroenterology.