J. Gu

发表

Pharmacological boosting of cGAS activation sensitizes chemotherapy by enhancing antitumor immunity.

Yiyan Fei, Haipeng Liu, Zhu Xu, 2023, Cell reports.

Biology drives the discovery of bispecific antibodies as innovative therapeutics.

Zhuozhi Wang, Jianqing Xu, Siwei Nie, 2020, Antibody therapeutics.

Functional Interaction of DFF35 and DFF45 with Caspase-activated DNA Fragmentation Nuclease DFF40*

Mei X. Wu, J. Gu, S. Schlossman, 1999, The Journal of Biological Chemistry.

Generation and characterization of ABBV642, a dual variable domain immunoglobulin molecule (DVD-Ig) that potently neutralizes VEGF and PDGF-BB and is designed for the treatment of exudative age-related macular degeneration

Anca Clabbers, T. Ghayur, L. Benatuil, 2017, mAbs.

p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

Jijie Gu, Surender Kharbanda, Zhi-Min Yuan, 1999, Nature.

Identification of p53 Sequence Elements That Are Required for MDM2-Mediated Nuclear Export

D. Wiederschain, Zhi-Min Yuan, J. Gu, 2001, Molecular and Cellular Biology.

A sequence element of p53 that determines its susceptibility to viral oncoprotein-targeted degradation

Zhi-Min Yuan, J. Gu, R. Rubin, 2001, Oncogene.

Mutual Dependence of MDM2 and MDMX in Their Functional Inactivation of p53*

A. Jochemsen, H. Kawai, D. Wiederschain, 2002, The Journal of Biological Chemistry.

Rationale and development of multispecific antibody drugs

T. Ghayur, Jijie Gu, J. Gu, 2010, Expert review of clinical pharmacology.

Mechanism of functional inactivation of a Li-Fraumeni syndrome p53 that has a mutation outside of the DNA-binding domain.

H. Kawai, D. Wiederschain, Z. Yuan, 2001, Cancer research.

Molecular Basis of p53 Functional Inactivation by the Leukemic Protein MLL-ELL

A. Shilatifard, H. Kawai, D. Wiederschain, 2003, Molecular and Cellular Biology.

Identification of a Sequence Element from p53 That Signals for Mdm2-Targeted Degradation

Zhi-Min Yuan, J. Gu, Dongli Chen, 2000, Molecular and Cellular Biology.

Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions.

G. Freeman, J. Gu, Y. Xu, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice

Mei X. Wu, R. Edwards, J. Gu, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin

Sahana Bose, Anca Clabbers, T. Ghayur, 2007, Nature Biotechnology.

ABT-165, a Dual Variable Domain Immunoglobulin (DVD-Ig) Targeting DLL4 and VEGF, Demonstrates Superior Efficacy and Favorable Safety Profiles in Preclinical Models

L. Naumovski, S. Morgan-Lappe, E. DiGiammarino, 2018, Molecular Cancer Therapeutics.

Identification of Anti-ErbB2 Dual Variable Domain Immunoglobulin (DVD-Ig™) Proteins with Unique Activities

T. Ghayur, Jieyi Wang, Xiaoqing Lu, 2014, PloS one.

erratum: p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

R. Weichselbaum, Zhi-Min Yuan, D. Kufe, 1999, Nature.

Structure reveals function of the dual variable domain immunoglobulin (DVD-Ig™) molecule

C. Jakob, T. Ghayur, R. Judge, 2013, mAbs.

Validation of a CRISPR/cas9-based technology platform for examining specific immune gene functions in an experimental murine model of IBD

Namjin Chung, E. Fiebiger, T. Ghayur, 2019, bioRxiv.

Mutual Dependence of MDM 2 and MDMX in Their Functional Inactivation of p 53 *

H. Kawai, D. Wiederschain, H. Kitao, 2002 .

The Bcl-2 Family Antagonist ABT-737 Significantly Inhibits Multiple Animal Models of Autoimmunity

Christian Goess, S. Mathieu, S. Rosenberg, 2009, The Journal of Immunology.

Potent and conditional redirected T cell killing of tumor cells using Half DVD-Ig

T. Ghayur, Jieyi Wang, Matthew M. Staron, 2017, Protein & Cell.

Generation of dual-variable-domain immunoglobulin molecules for dual-specific targeting.

T. Ghayur, J. Gu, 2012, Methods in enzymology.

Dual-Variable Domain Immunoglobulin (DVD-Ig™) Technology: A Versatile, Novel Format for the Next Generation of Dual-Targeting Biologics

Edit Tarcsa, Wolfgang Fraunhofer, Tariq Ghayur, 2011 .

Identification of Anti-EGFR and Anti-ErbB3 Dual Variable Domains Immunoglobulin (DVD-Ig) Proteins with Unique Activities

T. Ghayur, Zhihong Liu, Qing Chang, 2015, PloS one.

CRISPR/Cas9-targeting of CD40 in hematopoietic stem cells limits immune activation mediated by anti-CD40

Namjin Chung, S. Westmoreland, T. Ghayur, 2020, PloS one.

Subcellular distribution of p53 and p73 are differentially regulated by MDM2.

L. Nie, H. Kawai, Z. Yuan, 2001, Cancer research.

Evidence for a Distinct Inhibitory Factor in the Regulation of p53 Functional Activity*

D. Wiederschain, Zhi-Min Yuan, Jijie Gu, 2001, The Journal of Biological Chemistry.

Structure reveals function of the dual variable domain immunoglobulin (DVD-Ig™) molecule

C. Jakob, T. Ghayur, R. Judge, 2013, mAbs.

Rationale and development of multispecific antibody drugs

T. Ghayur, J. Gu, 2010, Expert review of clinical pharmacology.