Lixue Lu

Optimization of carbazole carboxamide RORγt agonists: Challenges in improving the metabolic stability and maintaining the agonistic activity.

Yonghui Wang, Shijie Chen, Ming-cheng Yu, 2023, European journal of medicinal chemistry.

Discovery of novel BTK PROTACs for B-Cell lymphomas.

Yonghui Wang, Zhendong Chen, Yan-Fang Bao, 2021, European journal of medicinal chemistry.

Discovery of novel triazine derivatives as potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists.

Yonghui Wang, Shijie Chen, Ming-cheng Yu, 2023, European journal of medicinal chemistry.

Development and therapeutic potential of allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists for autoimmune diseases.

Yonghui Wang, Nan-nan Sun, Lixue Lu, 2023, European journal of medicinal chemistry.

RORγt agonist synergizes with CTLA-4 antibody to inhibit tumor growth through inhibition of Treg cells via TGF-β signaling in cancer.

Di Zhu, Ming-cheng Yu, Qiong Xie, 2021, Pharmacological research.

Discovery of novel BTK PROTACs with improved metabolic stability via linker rigidification strategy.

Yonghui Wang, Xufen Yu, Zhendong Chen, 2023, European journal of medicinal chemistry.

Blockade of de novo pyrimidine biosynthesis triggers autophagic degradation of oncoprotein FLT3-ITD in acute myeloid leukemia

Yonghui Wang, Weiqiang Lu, Zehui Liu, 2023, Oncogene.

Discovery of Biaryl Amide Derivatives as Potent, Selective, and Orally Bioavailable RORγt Agonists for Cancer Immunotherapy.

Yonghui Wang, Ming-cheng Yu, Yunpeng Zhao, 2023, Journal of medicinal chemistry.