M. Brown

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Atherosclerosis: the low-density lipoprotein receptor hypothesis.

M. Brown, J. Goldstein, M. Brown, 1977, Metabolism: clinical and experimental.

Familial hypercholesterolemia: A genetic defect in the low-density lipoprotein receptor.

M. Brown, J. Goldstein, Michael S. Brown, 1976, The New England journal of medicine.

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.

R. Hammer, I. Shimomura, M. Brown, 1996, The Journal of clinical investigation.

Mutant clone of Chinese hamster ovary cells lacking 3-hydroxy-3 -methylglutaryl coenzyme A reductase.

M. Brown, J. Goldstein, R. G. Anderson, 1983, The Journal of biological chemistry.

Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys.

T. Südhof, M. Brown, J. Goldstein, 1992, The Journal of biological chemistry.

Preparation of recombinant Rab geranylgeranyltransferase and Rab escort proteins.

S. Armstrong, M. Brown, J. Goldstein, 1995, Methods in enzymology.

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells.

A. Levinson, M. Brown, J. Goldstein, 1993, Science.

Retinal degeneration in choroideremia: deficiency of rab geranylgeranyl transferase.

M. Brown, J. Goldstein, Michael S. Brown, 1993, Science.

Degradation of low density lipoprotein . dextran sulfate complexes associated with deposition of cholesteryl esters in mouse macrophages.

M. Brown, J. Goldstein, Y. Ho, 1979, The Journal of biological chemistry.

Receptor-mediated endocytosis of low-density lipoprotein in cultured cells.

M. Brown, J. Goldstein, Michael S. Brown, 1983, Methods in enzymology.

The LDL receptor defect in familial hypercholesterolemia. Implications for pathogenesis and therapy.

M. Brown, J. Goldstein, Michael S. Brown, 1982, The Medical clinics of North America.

Cholesteryl ester synthesis in macrophages: stimulation by beta-very low density lipoproteins from cholesterol-fed animals of several species.

R. Mahley, M. Brown, J. Goldstein, 1980, Journal of lipid research.

Hydrolysis and excretion of cytoplasmic cholesteryl esters by macrophages: stimulation by high density lipoprotein and other agents.

M. Brown, J. Goldstein, Michael S. Brown, 1980, Journal of lipid research.

The scavenger cell pathway for lipoprotein degradation: specificity of the binding site that mediates the uptake of negatively-charged LDL by macrophages.

M. Brown, J. Falck, J. Goldstein, 1980, Journal of supramolecular structure.

SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation.

R. Hammer, M. Matsuda, I. Shimomura, 2001, Genes & development.

Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice.

R. Hammer, M. Matsuda, I. Shimomura, 2000, Molecular cell.

Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes.

I. Shimomura, M. Brown, J. Horton, 1999, Proceedings of the National Academy of Sciences of the United States of America.

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood.

M. Brown, J. Goldstein, Michael S. Brown, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL.

M. Brown, H. Shimano, J. Horton, 1999, The Journal of clinical investigation.

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

R. Hammer, I. Shimomura, M. Brown, 1998, The Journal of clinical investigation.

Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic.

M. Brown, J. Goldstein, M. Brown, 1983, The Journal of clinical investigation.

Sterol regulatory element binding proteins (SREBPs): controllers of lipid synthesis and cellular uptake.

M. Brown, J. Goldstein, Michael S. Brown, 2009, Nutrition reviews.

Surface Spreading and Immunostaining of Yeast Chromosomes.

M. Brown, D. K. Bishop, M. Brown, 2015, Journal of visualized experiments : JoVE.

The Lebanese allele at the low density lipoprotein receptor locus. Nonsense mutation produces truncated receptor that is retained in endoplasmic reticulum.

D. Russell, M. Brown, J. Goldstein, 1987, The Journal of biological chemistry.

A receptor-mediated pathway for cholesterol homeostasis.

M. Brown, J. Goldstein, M. Brown, 1986, Science.

Assignment of the human gene for the low density lipoprotein receptor to chromosome 19: synteny of a receptor, a ligand, and a genetic disease.

U. Francke, M. Brown, J. Goldstein, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Reduction in cholesterol and low density lipoprotein synthesis after portacaval shunt surgery in a patient with homozygous familial hypercholesterolemia.

S. Grundy, D. Bilheimer, M. Brown, 1975, The Journal of clinical investigation.

Biochemical and genetic studies of the apoprotein E secreted by mouse macrophages and human monocytes.

M. Brown, J. Goldstein, R. G. Anderson, 1982, The Journal of biological chemistry.

The low-density lipoprotein pathway and its relation to atherosclerosis.

M. Brown, J. Goldstein, M. Brown, 1977, Annual review of biochemistry.

Alu-Alu recombination deletes splice acceptor sites and produces secreted low density lipoprotein receptor in a subject with familial hypercholesterolemia.

D. Russell, M. Brown, J. Goldstein, 1987, The Journal of biological chemistry.

Defective lipoprotein receptors and atherosclerosis. Lessons from an animal counterpart of familial hypercholesterolemia.

T. Kita, M. Brown, J. Goldstein, 1983, The New England journal of medicine.

Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis.

M. Brown, J. Goldstein, M. Brown, 1983, Annual review of biochemistry.

Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins.

M. Brown, J. Goldstein, Michael S. Brown, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells.

P. Espenshade, M. Brown, J. Goldstein, 1998, Molecular cell.

Overloading human aortic smooth muscle cells with low density lipoprotein-cholesteryl esters reproduces features of atherosclerosis in vitro.

M. Brown, J. Goldstein, R. G. Anderson, 1977, The Journal of clinical investigation.

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by lipoproteins.

M. Brown, J. Goldstein, Michael S. Brown, 1973, Proceedings of the National Academy of Sciences of the United States of America.

Identification of four novel human G protein-coupled receptors expressed in the brain.

B. O'dowd, S. George, M. Brown, 2001, Brain research. Molecular brain research.

Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.

R. Hammer, M. Brown, J. Goldstein, 1993, The Journal of clinical investigation.

Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition.

M. Brown, J. Goldstein, Michael S. Brown, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Active and inactive forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the liver of the rat. Comparison with the rate of cholesterol synthesis in different physiological states.

M. Brown, J. Goldstein, J. Dietschy, 1979, The Journal of biological chemistry.

The cholesteryl ester cycle in macrophage foam cells. Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters.

M. Brown, J. Goldstein, Michael S. Brown, 1980, The Journal of biological chemistry.

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs.

X. Chen, M. Brown, R. Prywes, 2000, Molecular cell.

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy.

R. Hammer, I. Shimomura, J. Richardson, 1998, Genes & development.

Stimulation of the synthesis of very low density lipoproteins in rooster liver by estradiol.

M. Brown, J. Goldstein, K. Luskey, 1974, The Journal of biological chemistry.

Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence.

M. Brown, J. Goldstein, Michael S. Brown, 1993, The Journal of biological chemistry.

Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1.

T. Südhof, P. Dawson, M. Brown, 1988, The Journal of biological chemistry.

Three direct repeats and a TATA-like sequence are required for regulated expression of the human low density lipoprotein receptor gene.

T. Südhof, D. Russell, M. Brown, 1987, The Journal of biological chemistry.

Binding and degradation of low density lipoproteins by cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia.

M. Brown, J. Goldstein, J L Goldstein, 1974, The Journal of biological chemistry.

The LDL receptor locus and the genetics of familial hypercholesterolemia.

M. Brown, J. Goldstein, J L Goldstein, 1979, Annual review of genetics.

Surface distribution and recycling of the low density lipoprotein receptor as visualized with antireceptor antibodies

Richard G. W. Anderson, M. Brown, J. Goldstein, 1982, The Journal of cell biology.

Reversible accumulation of cholesteryl esters in macrophages incubated with acetylated lipoproteins

Richard G. W. Anderson, M. Krieger, M. Brown, 1979, The Journal of cell biology.

Reconstituted low density lipoprotein: a vehicle for the delivery of hydrophobic fluorescent probes to cells.

M. Krieger, A. Gotto, H. Pownall, 1979, Journal of supramolecular structure.

Low-density lipoprotein (LDL) receptor activity in human acute myelogenous leukemia cells.

M. Brown, J. Goldstein, Y. Ho, 1978, Blood.

Receptor-mediated control of cholesterol metabolism.

M. Brown, J. Goldstein, M. Brown, 1976, Science.

Familial hypercholesterolemia: genetic, biochemical and pathophysiologic considerations.

M. Brown, J. Goldstein, M. Brown, 1975, Advances in internal medicine.

Effect of alterations of the specific activity of the intracellular acetyl CoA pool on apparent rates of hepatic cholesterogenesis.

M. Brown, J. Dietschy, M. Brown, 1974, Journal of lipid research.

Deletion in the gene for the low-density-lipoprotein receptor in a majority of French Canadians with familial hypercholesterolemia.

H. Hobbs, D. Russell, M. Brown, 1987, The New England journal of medicine.

Familial hypercholesterolemia: pathogenesis of a receptor disease.

M. Brown, J. Goldstein, M. Brown, 1978, The Johns Hopkins medical journal.

Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol.

M. Brown, J. Goldstein, Michael S. Brown, 1973, Proceedings of the National Academy of Sciences of the United States of America.

Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase.

L. Gierasch, Y. Reiss, M. Brown, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Replacement of endogenous cholesteryl esters of low density lipoprotein with exogenous cholesteryl linoleate. Reconstitution of a biologically active lipoprotein particle.

M. Krieger, M. Brown, J. Goldstein, 1978, The Journal of biological chemistry.

Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors.

R. Hammer, M. Brown, J. Goldstein, 1990, Science.

Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes.

R J Havel, R. Mahley, R. Havel, 1982, Journal of lipid research.

Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit.

P. Casey, Y. Reiss, M. Brown, 1991, Cell.

Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts.

M. Brown, J. Goldstein, Michael S. Brown, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Increased binding of low density lipoprotein to liver membranes from rats treated with 17 alpha-ethinyl estradiol.

M. Brown, P. Kovanen, J. Goldstein, 1979, The Journal of biological chemistry.

Inefficient internalization of receptor-bound low density lipoprotein in human carcinoma A-431 cells

M. Brown, J. Goldstein, Michael S. Brown, 1981, The Journal of cell biology.

DNA strand exchange and RecA homologs in meiosis.

M. Brown, D. K. Bishop, M. Brown, 2014, Cold Spring Harbor perspectives in biology.

Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice.

D K Burns, D. Burns, M. Brown, 1994, The Journal of clinical investigation.

Mutations affecting the binding, internalization, and lysosomal hydrolysis of low density lipoprotein in cultured human fibroblasts, lymphocytes, and aortic smooth muscle cells.

M. Brown, J. Goldstein, R. G. Anderson, 1977, Journal of supramolecular structure.

The LDL pathway in human fibroblasts: a receptor-mediated mechanism for the regulation of cholesterol metabolism.

M. Brown, J. Goldstein, Michael S. Brown, 1976, Current topics in cellular regulation.

Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit.

D. Russell, M. Brown, J. Goldstein, 1986, Science.

Liver transplantation to provide low-density-lipoprotein receptors and lower plasma cholesterol in a child with homozygous familial hypercholesterolemia.

S. Grundy, T. Starzl, D. Bilheimer, 1984, The New England journal of medicine.

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its mRNA in rat liver as studied with a monoclonal antibody and a cDNA probe.

M. Brown, J. Goldstein, D. Chin, 1983, The Journal of biological chemistry.

Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth.

M. Brown, J. Goldstein, M. Brown, 1980, Journal of lipid research.

Receptor-mediated endocytosis: concepts emerging from the LDL receptor system.

D. Russell, M. Brown, J. Goldstein, 1985, Annual review of cell biology.

Co-localization of 125I-epidermal growth factor and ferritin-low density lipoprotein in coated pits: a quantitative electron microscopic study in normal and mutant human fibroblasts

L. Orci, M. Brown, S. Cohen, 1982, The Journal of cell biology.

Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-Ras-transformed Rat-1 cells, but not in untransformed cells.

M. Cobb, M. Brown, J. Goldstein, 1994, The Journal of biological chemistry.

Esterification of low density lipoprotein cholesterol in human fibroblasts and its absence in homozygous familial hypercholesterolemia.

M. Brown, J. Goldstein, Michael S. Brown, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi.

M. S. Brown, M. Brown, J. Goldstein, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N.

M. Brown, J. Goldstein, Michael S. Brown, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Sterol-resistant transcription in CHO cells caused by gene rearrangement that truncates SREBP-2.

J. Goldstein, Michael S. Brown, R. Sato, 1994, Genes & development.

Cholesterol ester formation in cultured human fibroblasts. Stimulation by oxygenated sterols.

M. Brown, J. Goldstein, S. E. Dana, 1975, The Journal of biological chemistry.

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.

M. Brown, J. Goldstein, Michael S. Brown, 1990, The Journal of biological chemistry.

The clinical investigator: bewitched, bothered, and bewildered--but still beloved.

M. Brown, J. Goldstein, J L Goldstein, 1997, The Journal of clinical investigation.

Apolipoprotein C-I modulates the interaction of apolipoprotein E with beta-migrating very low density lipoproteins (beta-VLDL) and inhibits binding of beta-VLDL to low density lipoprotein receptor-related protein.

R. Mahley, K. Weisgraber, M. Brown, 1990, The Journal of biological chemistry.

Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein.

R. Mahley, K. Weisgraber, M. Brown, 1990, The Journal of biological chemistry.

The estradiol-stimulated lipoprotein receptor of rat liver. A binding site that membrane mediates the uptake of rat lipoproteins containing apoproteins B and E.

Y. Chao, R. Havel, M. Brown, 1980, The Journal of biological chemistry.

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta.

I. Shimomura, D. Mangelsdorf, J. Repa, 2000, Genes & development.

Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog.

D. Bilheimer, M. Brown, P. Kovanen, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase.

M. Brown, J. Goldstein, I. Kaneko, 1978, The Journal of biological chemistry.

Inhibition of proteolytic degradation of low density lipoprotein in human fibroblasts by chloroquine, concanavalin A, and Triton WR 1339.

M. Brown, J. Goldstein, G. Y. Brunschede, 1975, The Journal of biological chemistry.

Multiple mRNAs for 3-hydroxy-3-methylglutaryl coenzyme A reductase determined by multiple transcription initiation sites and intron splicing sites in the 5'-untranslated region.

M. Brown, J. Goldstein, Michael S. Brown, 1985, The Journal of biological chemistry.

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.

R. Hammer, I. Shimomura, M. Brown, 1997, The Journal of clinical investigation.

Inactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in vitro. An adenine nucleotide-dependent reaction catalyzed by a factor in human fibroblasts.

M. Brown, J. Goldstein, G. Y. Brunschede, 1975, The Journal of biological chemistry.

Overexpression of human low density lipoprotein receptors leads to accelerated catabolism of Lp(a) lipoprotein in transgenic mice.

R. Hammer, M. Brown, J. Goldstein, 1990, The Journal of clinical investigation.

Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.

S M Grundy, S. Grundy, D. Bilheimer, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Plasma lipoproteins: teaching old dogmas new tricks.

M. Brown, J. Goldstein, M. Brown, 1987, Nature.

Regulation of plasma cholesterol by lipoprotein receptors.

M. Brown, P. Kovanen, J. Goldstein, 1981, Science.

Cloning and expression of a cDNA encoding the alpha subunit of rat p21ras protein farnesyltransferase.

M. Brown, D. Andres, J. Goldstein, 1991, Proceedings of the National Academy of Sciences of the United States of America.

How LDL receptors influence cholesterol and atherosclerosis.

M. Brown, J. Goldstein, J L Goldstein, 1984, Scientific American.

Progress in understanding the LDL receptor and HMG-CoA reductase, two membrane proteins that regulate the plasma cholesterol.

M. Brown, J. Goldstein, M. Brown, 1984, Journal of lipid research.

Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).

R. Hammer, I. Shimomura, M. Brown, 1998, The Journal of clinical investigation.

Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs.

M. T. Hasan, J. Ye, M. Brown, 1997, Molecular cell.

Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver.

I. Shimomura, M. Brown, H. Shimano, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.

R. Hammer, I. Shimomura, M. Brown, 1997, The Journal of clinical investigation.

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.

I. Shimomura, M. Brown, H. Shimano, 1997, The Journal of clinical investigation.

Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver.

M. Brown, H. Otani, J. Goldstein, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13.

H. Hobbs, M. Brown, X. Hua, 1995, Genomics.

Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1).

M. Brown, M. Evans, J. Goldstein, 1994, The Journal of biological chemistry.

SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.

M. Brown, X. Hua, J. Wu, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization.

X. Wang, M. Brown, X. Hua, 1993, The Journal of biological chemistry.

Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice.

R. Hammer, D. Russell, M. Brown, 1988, Science.

Cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase from the hamster. I. Isolation and sequencing of a full-length cDNA.

C. Slaughter, M. Brown, J. Goldstein, 1986, The Journal of biological chemistry.

Monoclonal antibodies to the low density lipoprotein receptor as probes for study of receptor-mediated endocytosis and the genetics of familial hypercholesterolemia.

M. Brown, J. Goldstein, U. Beisiegel, 1981, The Journal of biological chemistry.

Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands.

M. Brown, J. Goldstein, Michael S. Brown, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of SREBP Processing and Membrane Lipid Production by Phospholipids in Drosophila

M. Brown, J. Goldstein, Michael S. Brown, 2002, Science.

Sphingomyelin depletion in cultured cells blocks proteolysis of sterol regulatory element binding proteins at site 1.

M. Brown, J. Goldstein, Michael S. Brown, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines.

M. Brown, X. Hua, J. Goldstein, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis.

X. Wang, M. Brown, J. Goldstein, 1996, The EMBO journal.

Purification of an Interleukin-1 Converting Enzyme-related Cysteine Protease That Cleaves Sterol Regulatory Element-binding Proteins between the Leucine Zipper and Transmembrane Domains (*)

C. Slaughter, X. Wang, M. Brown, 1995, The Journal of Biological Chemistry.

Translocation of oxysterol binding protein to Golgi apparatus triggered by ligand binding

P. Dawson, N. Ridgway, M. Brown, 1992, The Journal of cell biology.

Loss of transcriptional repression of three sterol-regulated genes in mutant hamster cells.

M. Brown, J. Goldstein, K. Luskey, 1989, The Journal of biological chemistry.

Multiple sterol regulatory elements in promoter for hamster 3-hydroxy-3-methylglutaryl-coenzyme A synthase.

J. R. Smith, T. Osborne, M. Brown, 1988, The Journal of biological chemistry.

Optional exon in the 5'-untranslated region of 3-hydroxy-3-methylglutaryl coenzyme A synthase gene: conserved sequence and splicing pattern in humans and hamsters.

J. R. Smith, M. Brown, J. Goldstein, 1987, Proceedings of the National Academy of Sciences of the United States of America.

cDNA cloning of human oxysterol-binding protein and localization of the gene to human chromosome 11 and mouse chromosome 19.

U. Francke, P. Dawson, C. Hsieh, 1990, Genomics.

The low density lipoprotein receptor in Xenopus laevis. I. Five domains that resemble the human receptor.

M. Brown, K. Mehta, J. Goldstein, 1991, The Journal of biological chemistry.

The LDL receptor gene: a mosaic of exons shared with different proteins.

T. Südhof, D. Russell, M. Brown, 1985, Science.

Cassette of eight exons shared by genes for LDL receptor and EGF precursor.

T. Südhof, D. Russell, G. Bell, 1985, Science.

Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease.

M. S. Brown, N. Grishin, J. Goldstein, 2000, Proceedings of the National Academy of Sciences of the United States of America.

The low density lipoprotein receptor. Identification of amino acids in cytoplasmic domain required for rapid endocytosis.

D. Russell, M. Brown, J. Goldstein, 1987, The Journal of biological chemistry.

Use of antipeptide antibodies to demonstrate external orientation of the NH2-terminus of the low density lipoprotein receptor in the plasma membrane of fibroblasts

J. D. Capra, C. Slaughter, M. Brown, 1983, The Journal of cell biology.

Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor.

M. S. Brown, M. Brown, J. Goldstein, 1995, Proceedings of the National Academy of Sciences of the United States of America.

First cysteine-rich repeat in ligand-binding domain of low density lipoprotein receptor binds Ca2+ and monoclonal antibodies, but not lipoproteins.

T. Südhof, M. Brown, J. Goldstein, 1987, The Journal of biological chemistry.

Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase.

M. Brown, J. Goldstein, Michael S. Brown, 1980, The Journal of clinical investigation.

Cholesteryl ester accumulation in macrophages resulting from receptor-mediated uptake and degradation of hypercholesterolemic canine beta-very low density lipoproteins.

R. Mahley, M. Brown, J. Goldstein, 1980, The Journal of biological chemistry.

Nonfarnesylated tetrapeptide inhibitors of protein farnesyltransferase.

L. Gierasch, Y. Reiss, M. Brown, 1991, Journal of Biological Chemistry.

Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows.

R. Mahley, R. Havel, J. Kane, 1981, The Journal of clinical investigation.

Inhibition of cholesteryl ester formation in human fibroblasts by an analogue of 7-ketocholesterol and by progesterone.

M. Brown, J. Goldstein, J. Faust, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Role of the low density lipoprotein receptor in regulating the content of free and esterified cholesterol in human fibroblasts.

M. Brown, J. Goldstein, J. Faust, 1975, The Journal of clinical investigation.

Visualization of lipoprotein receptors by ligand blotting.

M. Brown, J. Goldstein, W. Schneider, 1983, The Journal of biological chemistry.

Independent pathways for secretion of cholesterol and apolipoprotein E by macrophages.

M. Brown, J. Goldstein, Michael S. Brown, 1983, Science.

Mouse macrophages synthesize and secrete a protein resembling apolipoprotein E.

R. Havel, M. Brown, J. Goldstein, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Immunoblot analysis of low density lipoprotein receptors in fibroblasts from subjects with familial hypercholesterolemia.

M. Brown, J. Goldstein, U. Beisiegel, 1982, The Journal of biological chemistry.

Imaging of hepatic low density lipoprotein receptors by radionuclide scintiscanning in vivo.

J. Corbett, M. Brown, J. Goldstein, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Use of monoclonal anti-receptor antibodies to probe the expression of the low density lipoprotein receptor in tissues of normal and Watanabe heritable hyperlipidemic rabbits.

M. Brown, J. Goldstein, Michael S. Brown, 1984, The Journal of clinical investigation.

Partial deletion of membrane-bound domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase eliminates sterol-enhanced degradation and prevents formation of crystalloid endoplasmic reticulum

M. Brown, J. Goldstein, Michael S. Brown, 1987, The Journal of cell biology.

Multivalent control of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Mevalonate-derived product inhibits translation of mRNA and accelerates degradation of enzyme.

M. Nakanishi, M. Brown, J. Goldstein, 1988, The Journal of biological chemistry.

Geranylgeranylated Rab proteins terminating in Cys-Ala-Cys, but not Cys-Cys, are carboxyl-methylated by bovine brain membranes in vitro.

M. Brown, J. Goldstein, M. Seabra, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins.

M. Brown, J. Goldstein, Michael S. Brown, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Squalene synthetase activity in human fibroblasts: regulation via the low density lipoprotein receptor.

M. Brown, J. Goldstein, J. Faust, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of cholesterol synthesis with compactin renders growth of cultured cells dependent on the low density lipoprotein receptor.

M. Brown, J. Goldstein, Michael S. Brown, 1979, The Journal of biological chemistry.

Synthesis of ubiquinone and cholesterol in human fibroblasts: regulation of a branched pathway.

M. Brown, J. Goldstein, Michael S. Brown, 1979, Archives of biochemistry and biophysics.

Localization of low density lipoprotein receptors on plasma membrane of normal human fibroblasts and their absence in cells from a familial hypercholesterolemia homozygote.

M. Brown, J. Goldstein, Michael S. Brown, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Binding, internalization, and hydrolysis of low density lipoprotein in long-term lymphoid cell lines from a normal subject and a patient with homozygous familial hypercholesterolemia

M. Brown, J. Goldstein, Y. Ho, 1976, The Journal of experimental medicine.

The LDL receptor and HMG-CoA reductase--two membrane molecules that regulate cholesterol homeostasis.

M. Brown, J. Goldstein, M. Brown, 1985, Current topics in cellular regulation.

Receptor-mediated endocytosis and the cellular uptake of low density lipoprotein.

M. Brown, J. Goldstein, R. G. Anderson, 1982, Ciba Foundation symposium.

Fluorescence visualization of receptor-bound low density lipoprotein in human fibroblasts.

M. Brown, J. Goldstein, R. G. Anderson, 1980, Journal of receptor research.

Receptor-mediated uptake of lipoprotein-cholesterol and its utilization for steroid synthesis in the adrenal cortex.

M. Brown, P. Kovanen, J. Goldstein, 1979, Recent progress in hormone research.

The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins.

N. Maeda, M. Brown, J. Goldstein, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene.

J. R. Smith, T. Osborne, M. Brown, 1990, The Journal of biological chemistry.

Characterization of the low density lipoprotein receptor in membranes prepared from human fibroblasts.

M. Brown, J. Goldstein, Michael S. Brown, 1978, The Journal of biological chemistry.

Saturation and suppression of hepatic lipoprotein receptors: a mechanism for the hypercholesterolemia of cholesterol-fed rabbits.

M. Brown, P. Kovanen, J. Goldstein, 1981, Proceedings of the National Academy of Sciences of the United States of America.

The Third Exon of the Budding Yeast Meiotic Recombination Gene HOP2 Is Required for Calcium-dependent and Recombinase Dmc1-specific Stimulation of Homologous Strand Assimilation*

Y. Chan, M. Brown, D. K. Bishop, 2014, The Journal of Biological Chemistry.

Homologous Strand Assimilation Recombinase Dmc 1-specific Stimulation of Required for Calcium-dependent and Is HOP 2 Meiotic Recombination Gene The Third Exon of the Budding Yeast DNA and Chromosomes :

Y. Chan, M. Brown, D. K. Bishop, 2014 .

Homologous Strand Assimilation Recombinase Dmc1-specific Stimulation of Required for Calcium-dependent and Is HOP2 Meiotic Recombination Gene The Third Exon of the Budding Yeast

Y. Chan, M. Brown, D. K. Bishop, 2014 .

Operator constitutive mutation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter abolishes protein binding to sterol regulatory element.

T. Osborne, M. Brown, J. Goldstein, 1988, The Journal of biological chemistry.

39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.

M. Brown, D. Strickland, J. Goldstein, 1991, The Journal of biological chemistry.

Partial purification and characterization of the low density lipoprotein receptor from bovine adrenal cortex.

M. Brown, J. Goldstein, W. Schneider, 1980, The Journal of biological chemistry.

Biosynthesis of N- and O-linked oligosaccharides of the low density lipoprotein receptor.

R. Cummings, S. Kornfeld, M. Brown, 1983, The Journal of biological chemistry.

Amplification of the gene for 3-hydroxy-3-methylglutaryl coenzyme A reductase, but not for the 53-kDa protein, in UT-1 cells.

M. Brown, J. Goldstein, D. Chin, 1983, The Journal of biological chemistry.

Molecular cloning of 3-hydroxy-3-methylglutaryl coenzyme a reductase and evidence for regulation of its mRNA.

M. Brown, J. Goldstein, D. Chin, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Appearance of crystalloid endoplasmic reticulum in compactin-resistant Chinese hamster cells with a 500-fold increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

M. Brown, J. Goldstein, Michael S. Brown, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Receptor-mediated endocytosis: insights from the lipoprotein receptor system.

M. Brown, J. Goldstein, J L Goldstein, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of cholesterol synthesis in rat adrenal gland through coordinate control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase activities.

M. Brown, J. Goldstein, S. Balasubramaniam, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Evidence for regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in nonhepatic tissues of rat.

M. Brown, J. Goldstein, J. Faust, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Restoration of a regulatory response to low density lipoprotein in acid lipase-deficient human fibroblasts.

M. Brown, J. Goldstein, G. Y. Brunschede, 1976, The Journal of biological chemistry.

Role of lysosomal acid lipase in the metabolism of plasma low density lipoprotein. Observations in cultured fibroblasts from a patient with cholesteryl ester storage disease.

A. Beaudet, M. Brown, J. Goldstein, 1975, The Journal of biological chemistry.

Receptor-dependent hydrolysis of cholesteryl esters contained in plasma low density lipoprotein.

M. Brown, J. Goldstein, S. E. Dana, 1975, Proceedings of the National Academy of Sciences of the United States of America.

Genetic heterogeneity in familial hypercholesterolemia: evidence for two different mutations affecting functions of low-density lipoprotein receptor.

M. Brown, J. Goldstein, G. Y. Brunschede, 1975, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia.

M. Brown, J. Goldstein, Michael S. Brown, 1974, The Journal of biological chemistry.

Recycling of cell-surface receptors: observations from the LDL receptor system.

M. Brown, J. Goldstein, Michael S. Brown, 1982, Cold Spring Harbor symposia on quantitative biology.

Mutation in LDL receptor: Alu-Alu recombination deletes exons encoding transmembrane and cytoplasmic domains.

T. Südhof, D. Russell, M. Brown, 1985, Science.

A common mitochondrial DNA variant is associated with insulin resistance in adult life

J. Poulton, D. Phillips, D. Marchington, 1998, Diabetologia.

Suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and inhibition of growth of human fibroblasts by 7-ketocholesterol.

M. Brown, J. Goldstein, M. Brown, 1974, The Journal of biological chemistry.

The LDL receptor locus in familial hypercholesterolemia: mutational analysis of a membrane protein.

H. Hobbs, D. Russell, M. Brown, 1990, Annual review of genetics.

cDNA Cloning of MCT2, a Second Monocarboxylate Transporter Expressed in Different Cells than MCT1 (*)

M. Brown, J. Goldstein, Ravindra Kumar Pathak, 1995, The Journal of Biological Chemistry.

PCR analysis of the immunoglobulin heavy chain gene in polyclonal processes can yield pseudoclonal bands as an artifact of low B cell number.

K. Elenitoba-Johnson, M. Brown, R. Mitchell, 2000, The Journal of molecular diagnostics : JMD.

Localization of mRNA for low density lipoprotein receptor and a cholesterol synthetic enzyme in rabbit nervous system by in situ hybridization.

L. Swanson, J. Goldstein, D. Simmons, 1988, Proceedings of the National Academy of Sciences of the United States of America.

mRNA for low density lipoprotein receptor in brain and spinal cord of immature and mature rabbits.

D. Russell, M. Brown, J. Goldstein, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Multiple genes encode nuclear factor 1-like proteins that bind to the promoter for 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

J. R. Smith, C. Slaughter, T. Osborne, 1988, Proceedings of the National Academy of Sciences of the United States of America.

cDNA cloning and expression of oxysterol-binding protein, an oligomer with a potential leucine zipper.

C. Slaughter, P. Dawson, N. Ridgway, 1989, The Journal of biological chemistry.

Purification of oxysterol binding protein from hamster liver cytosol.

P. Dawson, M. Brown, J. Goldstein, 1989, The Journal of biological chemistry.

PxF, a prenylated protein of peroxisomes.

M. Brown, J. Goldstein, R. G. Anderson, 1994, The Journal of biological chemistry.

Increased mRNA for low density lipoprotein receptor in livers of rabbits treated with 17 alpha-ethinyl estradiol.

M. Brown, J. Goldstein, T. Yamamoto, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Lipoprotein receptors and the control of plasma LDL cholesterol levels.

M. Brown, J. Goldstein, M. Brown, 1992, European heart journal.

Genetics of the low density lipoprotein receptor. Diminished receptor activity in lymphocytes from heterozygotes with familial hypercholesterolemia.

K., D. Bilheimer, M. Brown, 1978, The Journal of clinical investigation.

Atherosclerosis. Scavenging for receptors.

M. Brown, J. Goldstein, M. Brown, 1990, Nature.

Cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase from the hamster. II. Isolation of the gene and characterization of the 5' flanking region.

M. Brown, J. Goldstein, Michael S. Brown, 1986, The Journal of biological chemistry.

Hepatic uptake of chylomicron remnants in WHHL rabbits: a mechanism genetically distinct from the low density lipoprotein receptor.

R. Havel, T. Kita, C. Hornick, 1982, Proceedings of the National Academy of Sciences of the United States of America.

cDNA cloning of MEV, a mutant protein that facilitates cellular uptake of mevalonate, and identification of the point mutation responsible for its gain of function.

M. Brown, J. Goldstein, C. M. Kim, 1992, The Journal of biological chemistry.

Identification of promoter elements required for in vitro transcription of hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase gene.

T. Osborne, J. Goldstein, G. Gil, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum.

R. Stroud, J. Finer-Moore, M. Brown, 1985, The Journal of biological chemistry.

Small Rad51 and Dmc1 Complexes Often Co-occupy Both Ends of a Meiotic DNA Double Strand Break

Michael J Rust, M. Brown, D. K. Bishop, 2015, PLoS genetics.

Gradual implementation of the meiotic recombination program via checkpoint pathways controlled by global DSB levels.

Neeraj K. Joshi, M. Brown, D. K. Bishop, 2015, Molecular cell.

Purification of the low density lipoprotein receptor, an acidic glycoprotein of 164,000 molecular weight.

M. Brown, J. Goldstein, U. Beisiegel, 1982, The Journal of biological chemistry.

Sterols accelerate degradation of hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase encoded by a constitutively expressed cDNA.

M. Brown, J. Goldstein, Michael S. Brown, 1985, Molecular and cellular biology.

Sterols accelerate degradation of hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase encoded by a constitutively expressed cDNA

M. Brown, J. Goldstein, D. Chin, 1985 .

Isolation of Chinese hamster cell mutants defective in the receptor-mediated endocytosis of low density lipoprotein.

M. Krieger, M. Brown, J. Goldstein, 1981, Journal of molecular biology.

Immunologic cross-reactivity of the low density lipoprotein receptor from bovine adrenal cortex, human fibroblasts, canine liver and adrenal gland, and rat liver.

M. Brown, J. Goldstein, U. Beisiegel, 1981, The Journal of biological chemistry.

Receptor-mediated uptake of low density lipoprotein and utilization of its cholesterol for steroid synthesis in cultured mouse adrenal cells.

M. Brown, J. Goldstein, Michael S. Brown, 1977, The Journal of biological chemistry.

Inhibition of the binding of low-density lipoprotein to its cell surface receptor in human fibroblasts by positively charged proteins.

M. Brown, J. Goldstein, Michael S. Brown, 1978, Journal of supramolecular structure.

Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits.

T. Südhof, D. Bilheimer, M. Brown, 1986, Proceedings of the National Academy of Sciences of the United States of America.

REP-2, a Rab escort protein encoded by the choroideremia-like gene.

S. Armstrong, F. Cremers, J. Goldstein, 1994, The Journal of biological chemistry.

Evidence for a dominant gene that suppresses hypercholesterolemia in a family with defective low density lipoprotein receptors.

H. Hobbs, M. Brown, J. Goldstein, 1989, The Journal of clinical investigation.

Different combinations of cysteine-rich repeats mediate binding of low density lipoprotein receptor to two different proteins.

D. Russell, M. Brown, J. Goldstein, 1989, The Journal of biological chemistry.

Solubilization of the low density lipoprotein receptor.

M. Brown, J. Goldstein, Michael S. Brown, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Low density lipoprotein receptor-related protein mediates endocytosis of monoclonal antibodies in cultured cells and rabbit liver.

M. Brown, J. Goldstein, Michael S. Brown, 1990, The Journal of biological chemistry.

Regulation of low-density lipoprotein receptors: implications for pathogenesis and therapy of hypercholesterolemia and atherosclerosis.

M. Brown, J. Goldstein, J L Goldstein, 1987, Circulation.

3-Hydroxy-3-methylglutaryl-CoA reductase: a transmembrane glycoprotein of the endoplasmic reticulum with N-linked "high-mannose" oligosaccharides.

R. Cummings, J. Goldstein, R. G. Anderson, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Familial hypercholesterolemia. A genetic regulatory defect in cholesterol metabolism.

M. Brown, J. Goldstein, Michael S. Brown, 1975, The American journal of medicine.

Heart Attacks: Gone with the Century?

M. Brown, J. Goldstein, M. Brown, 1996, Science.

Assays for inhibitors of CAAX farnesyltransferase in vitro and in intact cells.

M. Brown, J. Goldstein, Michael S. Brown, 1995, Methods in enzymology.

Purification of acetokinase from Desulfovibrio desulfuricans

J. Akagi, M. Brown, 1966, Journal of bacteriology.

Regulation of synthesis and degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by low density lipoprotein and 25-hydroxycholesterol in UT-1 cells.

M. Brown, J. Goldstein, D. Chin, 1982, Proceedings of the National Academy of Sciences of the United States of America.

SREBPs: transcriptional mediators of lipid homeostasis.

J. Horton, J. Goldstein, Michael S. Brown, 2002, Cold Spring Harbor symposia on quantitative biology.

Familial hypercholesterolemia: a genetic receptor disease.

M. Brown, J. Goldstein, M. Brown, 1985, Hospital practice.

Cytoplasmic sequence required for basolateral targeting of LDL receptor in livers of transgenic mice

R. Hammer, M. Brown, J. Goldstein, 1992, The Journal of cell biology.

Cholesterol synthesis in vivo and in vitro in the WHHL rabbit, an animal with defective low density lipoprotein receptors.

M. Brown, J. Goldstein, Michael S. Brown, 1983, Journal of lipid research.

Biologically active low density lipoprotein in human peripheral lymph.

M. Brown, J. Goldstein, N. B. Myant, 1978, The Journal of clinical investigation.

Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance.

M. Brown, K. Orth, T. Willnow, 1992, The Journal of biological chemistry.

M. Brown, J. Goldstein, R. Bradley, 1978, Journal of lipid research.

MLK4β functions as a negative regulator of MAPK signaling and cell invasion

M. Brown, D. N. Chadee, W. A. Abi Saab, 2012, Oncogenesis.

Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity.

M. Brown, J. Goldstein, Michael S. Brown, 2009, Proceedings of the National Academy of Sciences of the United States of America.

The LDL receptor in familial hypercholesterolemia: use of human mutations to dissect a membrane protein.

T. Südhof, H. Hobbs, D. Russell, 1986, Cold Spring Harbor symposia on quantitative biology.

Deletion of exon encoding cysteine-rich repeat of low density lipoprotein receptor alters its binding specificity in a subject with familial hypercholesterolemia.

H. Hobbs, D. Russell, M. Brown, 1986, The Journal of biological chemistry.

Deletion of clustered O-linked carbohydrates does not impair function of low density lipoprotein receptor in transfected fibroblasts.

D. Russell, S. Kornfeld, M. Brown, 1986, The Journal of biological chemistry.

Regulation of low density lipoprotein receptors by adrenocorticotropin in the adrenal gland of mice and rats in vivo.

M. Brown, P. Kovanen, J. Goldstein, 1980, The Journal of biological chemistry.

Separate mechanisms for the uptake of high and low density lipoproteins by mouse adrenal gland in vivo.

M. Brown, P. Kovanen, J. Goldstein, 1979, The Journal of biological chemistry.

Lipoprotein-mediated regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesteryl ester metabolism in the adrenal gland of the rat.

M. Brown, J. Goldstein, G. Y. Brunschede, 1977, The Journal of biological chemistry.

Deficiency of low density lipoprotein receptors in liver and adrenal gland of the WHHL rabbit, an animal model of familial hypercholesterolemia.

T. Kita, M. Brown, J. Goldstein, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Mutational analysis of the ligand binding domain of the low density lipoprotein receptor.

D. Russell, M. Brown, J. Goldstein, 1988, The Journal of biological chemistry.

Visualization of acidic organelles in intact cells by electron microscopy.

M. Brown, J. Falck, J. Goldstein, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Divalent cation and prenyl pyrophosphate specificities of the protein farnesyltransferase from rat brain, a zinc metalloenzyme.

Y. Reiss, M. Brown, J. Goldstein, 1992, The Journal of biological chemistry.

Binding and internalization of 125I-LDL in normal and mutant human fibroblasts. A quantitative autoradiographic study.

L. Orci, M. Brown, J. Carpentier, 1979, Experimental cell research.

Hyperlipidemia in coronary heart disease: a biochemical genetic approach.

M. Brown, J. Goldstein, M. Brown, 1975, The Journal of laboratory and clinical medicine.

Delayed clearance of very low density and intermediate density lipoproteins with enhanced conversion to low density lipoprotein in WHHL rabbits.

D. Bilheimer, T. Kita, M. Brown, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Receptor-mediated uptake of low density lipoprotein reconstituted with 25-hydroxycholesteryl oleate suppresses 3-hydroxy-3-methylglutaryl-coenzyme A reductase and inhibits growth of human fibroblasts.

M. Krieger, M. Brown, J. Goldstein, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Occurrence of low density lipoprotein receptors within large pits on the surface of human fibroblasts as demonstrated by freeze-etching.

L Orci, L. Orci, M. Brown, 1978, Experimental cell research.

Molecular cloning of a histidine-rich Ca2+-binding protein of sarcoplasmic reticulum that contains highly conserved repeated elements.

C. Slaughter, M. Brown, K. Orth, 1989, The Journal of biological chemistry.

Low density lipoprotein receptors in bovine adrenal cortex. II. Low density lipoprotein binding to membranes prepared from fresh tissue.

M. Brown, P. Kovanen, J. Goldstein, 1979, Endocrinology.

Antibody against low density lipoprotein receptor blocks uptake of low density lipoprotein (but not high density lipoprotein) by the adrenal gland of the mouse in vivo.

J. Goldstein, U. Beisiegel, W. Schneider, 1981, The Journal of biological chemistry.

cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences.

U. Francke, T. Ozcelik, M. Brown, 1993, Genomics.

Molecular size of recombinant alpha1beta1 and alpha1beta1gamma2 GABAA receptors expressed in Sf9 cells.

J. Tallman, A. R. Knight, T. V. Ramabhadran, 1998, Receptors and Channels.

beta-Carotene as a probe of lipid domains of reconstituted human plasma low-density lipoprotein: induced circular dichroism.

M. Krieger, J. Kane, M. Brown, 1980, Biochemistry.

Purification of the LDL receptor.

M. Brown, J. Goldstein, W. Schneider, 1985, Methods in enzymology.

Purification of a protein doublet that binds to six TGG-containing sequences in the promoter for hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

T. Osborne, M. Brown, J. Goldstein, 1988, The Journal of biological chemistry.

Self-association of the low density lipoprotein receptor mediated by the cytoplasmic domain.

M. Brown, J. Goldstein, I. V. van Driel, 1987, The Journal of biological chemistry.

Immunocytochemical localization of mutant low density lipoprotein receptors that fail to reach the Golgi complex

R. Cummings, M. Brown, J. Goldstein, 1988, The Journal of cell biology.

A 25-hydroxycholesterol-resistant cell line deficient in acyl-CoA: cholesterol acyltransferase.

P. Dawson, N. Ridgway, M. Brown, 1991, The Journal of biological chemistry.

Modulation of glutamine synthetase adenylylation and deadenylylation is mediated by metabolic transformation of the P II -regulatory protein.

E. Stadtman, M. Brown, A. Segal, 1971, Proceedings of the National Academy of Sciences of the United States of America.

Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells.

M. Brown, J. Goldstein, Michael S. Brown, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Nonidentical subunits of p21H-ras farnesyltransferase. Peptide binding and farnesyl pyrophosphate carrier functions.

S. Armstrong, C. Slaughter, Y. Reiss, 1991, The Journal of biological chemistry.

Receptor-mediated endocytosis: concepts emerging from the LDL receptor system.

D. Russell, J. Goldstein, R. G. Anderson, 1985, Annual review of cell biology.

Tissue-specific sorting of the human LDL receptor in polarized epithelia of transgenic mice

R. Hammer, M. Brown, J. Goldstein, 1990, The Journal of cell biology.

cDNA cloning of the bovine low density lipoprotein receptor: feedback regulation of a receptor mRNA.

D. Russell, C. Slaughter, M. Brown, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Kinetic defects in the processing of the low density lipoprotein receptor in fibroblasts from WHHL rabbits and a family with familial hypercholesterolemia.

M. Brown, J. Goldstein, W. Schneider, 1983, Molecular biology & medicine.

Biochemical genetics of LDL receptor mutations in familial hypercholesterolemia.

M. Brown, J. Goldstein, B. Kottke, 1982, Progress in clinical and biological research.

3-Hydroxy-3-methylglutaryl-CoA reductase: a transmembrane glycoprotein of the endoplasmic reticulum with N-linked "high-mannose" oligosaccharides.

R. Cummings, J. Goldstein, R. G. Anderson, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Ultrastructural analysis of crystalloid endoplasmic reticulum in UT-1 cells and its disappearance in response to cholesterol.

L. Orci, L. Garcia-Segura, M. Brown, 1983, Journal of cell science.

Exon-Alu recombination deletes 5 kilobases from the low density lipoprotein receptor gene, producing a null phenotype in familial hypercholesterolemia.

D. Russell, M. Brown, J. Goldstein, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Homocystinuria due to cystathionine synthase deficiency: the effect of pyridoxine.

W. A. Edwards, M. Brown, L. Laster, 1970, The Journal of clinical investigation.

Low density lipoprotein receptors in bovine adrenal cortex. I. Receptor-mediated uptake of low density lipoprotein and utilization of its cholesterol for steroid synthesis in cultured adrenocortical cells.

M. Brown, P. Kovanen, J. Goldstein, 1979, Endocrinology.

Scavenger cell receptor shared.

J. Goldstein, M. Brown, 1985, Nature.

Molecular medicine. The cholesterol quartet.

M. Brown, J. Goldstein, M. Brown, 2001, Science.

Multiple crm- mutations in familial hypercholesterolemia. Evidence for 13 alleles, including four deletions.

H. Hobbs, D. Russell, M. Brown, 1988, The Journal of clinical investigation.

Structure and expression of two nuclear receptor genes in marsupials: insights into the evolution of the antisense overlap between the α-thyroid hormone receptor and Rev-erbα

M. Brown, J. VandeBerg, S. H. Munroe, 2010, BMC Molecular Biology.

Stimulation of Cholesteryl Ester Synthesis in Macrophages by Extracts of Atherosclerotic Human Aortas and Complexes of Albumin/Cholesteryl Esters

M. Brown, J. Goldstein, Michael S. Brown, 1981, Arteriosclerosis.

Interaction of swine lipoproteins with the low density lipoprotein receptor in human fibroblasts.

R. Mahley, M. Brown, J. Goldstein, 1976, The Journal of biological chemistry.

Lowering plasma cholesterol by raising LDL receptors.

M. Brown, J. Goldstein, Michael S. Brown, 1981, The New England journal of medicine.

cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase.

S. Armstrong, T. Südhof, M. Brown, 1993, The Journal of biological chemistry.

Mevinolin stimulates receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.

S. Grundy, D. Bilheimer, M. Brown, 1983, Transactions of the Association of American Physicians.

Protein prenylation. Mad bet for Rab.

M. Brown, J. Goldstein, M. Brown, 1993, Nature.

Purification of a sarcoplasmic reticulum protein that binds Ca2+ and plasma lipoproteins.

J. Goldstein, R. G. Anderson, Ravindra Kumar Pathak, 1989, The Journal of biological chemistry.

Stoichiometric binding of low density lipoprotein (LDL) and monoclonal antibodies to LDL receptors in a solid phase assay.

M. Brown, J. Goldstein, I. V. van Driel, 1989, The Journal of biological chemistry.

Demonstration of low density lipoprotein receptors in mouse teratocarcinoma stem cells and description of a method for producing receptor-deficient mutant mice.

M. Krieger, M. Brown, J. Goldstein, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Specific, saturable, and high affinity binding of 125I-low density lipoprotein to glass beads.

M. Brown, J. Goldstein, S. E. Dana, 1977, Biochemical and biophysical research communications.

Lipoprotein receptors and the genetic control of cholesterol metabolism in cultured human cells

M. Brown, J. Goldstein, M. Brown, 1975, Naturwissenschaften.

Steroid requirements for suppression of HMG CoA reductase activity in cultured human fibroblasts.

M. Brown, J. Goldstein, G. Y. Brunschede, 1975, Advances in experimental medicine and biology.

Lipoprotein receptors, cholesterol metabolism, and atherosclerosis.

M. Brown, J. Goldstein, M. Brown, 1975, Archives of pathology.

3-Hydroxy-3-methylglutaryl coenzyme A reductase. Solubilization and purification of a cold-sensitive microsomal enzyme.

M. Brown, J. Dietschy, S. E. Dana, 1973, The Journal of biological chemistry.

Targeted killing of cultured cells by receptor-dependent photosensitization.

M. Brown, J. Falck, J. Goldstein, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Gradual implementation of the meiotic recombination program via checkpoint pathways controlled by global DSB levels.

Neeraj K. Joshi, D. K. Bishop, G. Börner, 2015, Molecular cell.

Human low density lipoprotein receptor expressed in Xenopus oocytes. Conserved signals for O-linked glycosylation and receptor-mediated endocytosis.

D. Russell, M. Brown, J. Goldstein, 1988, The Journal of biological chemistry.

Lowering plasma cholesterol by raising ldl receptors. 1981.

J. Goldstein, J L Goldstein, M S Brown, 2004, Atherosclerosis. Supplements.

On the Mechanism of Action and Metabolic Control of the Multifunctional Enzyme Complex that Catalyzes Adenylylation and Deadenylylation of Escherichia coli Glutamine Synthetase

E. Stadtman, A. Segal, J. Mangum, 1972 .

Presentation of the Kober Medal for 1999 to Jean D. Wilson physician-scientist exemplar.

M. Brown, J. Goldstein, M. Brown, 1999, Proceedings of the Association of American Physicians.

3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human hair roots.

M. Brown, J. Goldstein, P. Brannan, 1975, Journal of lipid research.

New directions in human biochemical genetics: understanding the manifestations of receptor deficiency states.

J. Goldstein, M. Brown, 1976, Progress in medical genetics.

Identification of a cholesterol-regulated 53,000-dalton cytosolic protein in UT-1 cells and cloning of its cDNA.

J. Goldstein, D. Chin, L. Liscum, 1982, Proceedings of the National Academy of Sciences of the United States of America.

High levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in the ovary of the pregnant rabbit.

M. Brown, P. Kovanen, J. Goldstein, 1978, The Journal of biological chemistry.

Synthesis of delta 2-isopentenyl tRNA from mevalonate in cultured human fibroblasts.

M. Brown, J. Goldstein, J. Faust, 1980, The Journal of biological chemistry.