M. Albarrán

发表

Induction of Lysosome Membrane Permeabilization as a Therapeutic Strategy to Target Pancreatic Cancer Stem Cells

M. Serrano, C. Blanco-Aparicio, M. I. Albarrán, 2020, Cancers.

Exome Sequencing of Plasma DNA Portrays the Mutation Landscape of Colorectal Cancer and Discovers Mutated VEGFR2 Receptors as Modulators of Antiangiogenic Therapies

T. Pons, M. Hidalgo, C. Blanco-Aparicio, 2018, Clinical Cancer Research.

Biological characterization of ETP-46321 a selective and efficacious inhibitor of phosphoinositide-3-kinases

J. Bischoff, W. Link, S. Peregrina, 2013, Investigational New Drugs.

Chemical Interrogation of FOXO3a Nuclear Translocation Identifies Potent and Selective Inhibitors of Phosphoinositide 3-Kinases*

O. Rabal, J. Oyarzábal, J. Bischoff, 2009, The Journal of Biological Chemistry.

Whole-exome sequencing of plasma cell-free DNA portrays the somatic mutation landscape of refractory metastatic colorectal cancer and enables the discovery of mutated KDR/VEGFR2 receptors as modulators of anti-angiogenic therapies

T. Pons, M. Hidalgo, C. Blanco-Aparicio, 2017, bioRxiv.

Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach.

O. Rabal, J. Oyarzábal, Manuel Urbano-Cuadrado, 2010, Journal of medicinal chemistry.

Macrocyclization as a Source of Desired Polypharmacology. Discovery of Triple PI3K/mTOR/PIM Inhibitors.

N. Ajenjo, C. Blanco-Aparicio, R. Álvarez, 2021, ACS medicinal chemistry letters.

Discovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitors.

O. Rabal, J. Oyarzábal, J. Bischoff, 2019, European journal of medicinal chemistry.

Omipalisib inspired macrocycles as dual PI3K/mTOR inhibitors.

J. Oyarzábal, C. Blanco-Aparicio, R. Álvarez, 2020, European journal of medicinal chemistry.

Identification of novel PI3K inhibitors through a scaffold hopping strategy.

J. Bischoff, C. Blanco-Aparicio, R. Álvarez, 2017, Bioorganic & medicinal chemistry letters.

Fragment-Hopping-Based Discovery of a Novel Chemical Series of Proto-Oncogene PIM-1 Kinase Inhibitors

Obdulia Rabal, Julen Oyarzabal, Joaquin Pastor, 2012, PloS one.

Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.

J. Bischoff, R. Álvarez, M. I. Albarrán, 2017, Bioorganic & medicinal chemistry letters.