Stephen W. Fesik

发表

A method of designing and manufacturing of zielmolekulbindenden ligand

Stephen W. Fesik, Philip J. Hajduk, 1996 .

The Application and Development of Software Tools for the Processing and Analysis of Heteronuclear Multi-Dimensional NMR Data

Stephen W. Fesik, Edward T. Olejniczak, Hugh L. Eaton, 1991 .

Ligand binding to domain-3 of human serum albumin: a chemometric analysis

Yvonne C. Martin, Mark G. Bures, Jeffrey R. Huth, 2003, J. Comput. Aided Mol. Des..

Abstract IA-7: Fragment‐based cancer drug discovery

Stephen W. Fesik, 2009 .

Twenty years on: the impact of fragments on drug discovery

Harren Jhoti, Wolfgang Jahnke, Daniel A. Erlanson, 2016, Nature Reviews Drug Discovery.

NMR-Based Screening of Proteins Containing 13C-Labeled Methyl Groups

Renaldo Mendoza, Stephen W. Fesik, Philip J. Hajduk, 2000 .

Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation.

Qi Sun, Stephen W. Fesik, Edward T. Olejniczak, 2012, Angewandte Chemie.

ChemInform Abstract: Discovery of Potent Nonpeptide Inhibitors of Stromelysin Using SAR by NMR.

Karl A. Walter, Jean M. Severin, Stephen W. Fesik, 1997 .

The Use of Differential Chemical Shifts for Determining the Binding Site Location and Orientation of Protein-Bound Ligands

Stephen W. Fesik, Philip J. Hajduk, P. Hajduk, 2000 .

NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain

Stephen W. Fesik, Edward T. Olejniczak, R. Meadows, 1996, Nature.

NMR structure and mutagenesis of the FADD (Mort1) death-effector domain

Stephen W. Fesik, R. Meadows, S. Fesik, 1998, Nature.

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

Stephen F. Betz, Stephen W. Fesik, Edward T. Olejniczak, 2000, Nature.

NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP

Stephen W. Fesik, A. Gunasekera, Chaohong Sun, 1999, Nature.

The BH3 Domain of Bcl-xS Is Required for Inhibition of the Antiapoptotic Function of Bcl-xL

John E. Harlan, Ameeta Kelekar, Stephen W. Fesik, 1999, Molecular and Cellular Biology.

Fragment-based drug discovery using NMR spectroscopy

Stephen W. Fesik, S. Fesik, M. Harner, 2013, Journal of biomolecular NMR.

Lithium chloride perturbation of cis-trans peptide bond equilibria: effect on conformational equilibria in cyclosporin A and on time-dependent inhibition of cyclophilin

Stephen W. Fesik, Daniel H. Rich, S. Fesik, 1992 .

NMR Structure and Mutagenesis of the Third Bir Domain of the Inhibitor of Apoptosis Protein XIAP*

Stephen W. Fesik, A. Gunasekera, Chaohong Sun, 2000, The Journal of Biological Chemistry.

Bcl-xL forms an ion channel in synthetic lipid membranes

Andy J. Minn, Steven W. Muchmore, Michael Fill, 1997, Nature.

Stereospecific assignments and χ1 rotamers for FKBP when bound to ascomycin from 3 J Hα,Hβ and 3 J N,Hβ coupling constants

Stephen W. Fesik, Edward T. Olejniczak, E. Olejniczak, 1992 .

The Bcl-2 inhibitor ABT-263 enhances the response of multiple chemotherapeutic regimens in hematologic tumors in vivo

Saul H. Rosenberg, Stephen W. Fesik, C. Tse, 2010, Cancer Chemotherapy and Pharmacology.

Discovery of a Potent Stapled Helix Peptide That Binds to the 70N Domain of Replication Protein A

Stephen W. Fesik, Walter J. Chazin, Edward T. Olejniczak, 2014, Journal of medicinal chemistry.

Determining the Structure of a Glycopeptide-Acz-Lys-D-Ala-D-Ala Complex Using NMR Parameters and Molecular Modeling.

Stephen W. Fesik, Edward T. Olejniczak, T. J. O'donnell, 1986 .

Discovery of Inhibitors of Protein–Protein Interactions Using Fragment‐Based Methods

Stephen W. Fesik, S. Fesik, Feng Wang, 2016 .

Promoting apoptosis as a strategy for cancer drug discovery

Stephen W. Fesik, S. Fesik, 2005, Nature Reviews Cancer.

A computer-based protocol for semiautomated assignments and 3D structure determination of proteins

Stephen W. Fesik, Edward T. Olejniczak, R. Meadows, 1994, Journal of biomolecular NMR.

Two-Dimensional Nuclear Magnetic Resonance Method for Identifying the H.alpha./C.alpha. Signals of Amino Acid Residues Preceding Proline

Stephen W. Fesik, Edward T. Olejniczak, E. Olejniczak, 1994 .

Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Compound 12 Using a Linked-Fragment Strategy

Gang Liu, Charles W. Hutchins, Stephen W. Fesik, 2003 .

One-Dimensional Relaxation- and Diffusion-Edited NMR Methods for Screening Compounds That Bind to Macromolecules

Stephen W. Fesik, Philip J. Hajduk, P. Hajduk, 1997 .

Stereospecific assignments of glycine in proteins by stereospecific deuteration and 15N labeling

Stephen W. Fesik, S. Fesik, Robert W. Jr. Curley, 1994, Journal of biomolecular NMR.

A model of the cyclophilin/cyclosporin A (CSA) complex from NMR and X-ray data suggests that CSA binds as a transition-state analog

Stephen W. Fesik, Edward T. Olejniczak, R. Meadows, 1992 .