Shou-wu Ma

发表

Development of potent μ and δ opioid agonists with high lipophilicity.

V. Hruby, T. Vanderah, F. Porreca, 2011, Journal of medicinal chemistry.

Synthesis and biological evaluation of new biphalin analogues with non-hydrazine linkers.

V. Hruby, A. Mollica, F. Porreca, 2005, Bioorganic & medicinal chemistry letters.

An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons

F. Porreca, J. Lai, S. Shuster, 2005, Molecular pain.

Dynorphin A activates bradykinin receptors to maintain neuropathic pain

Qingmin Chen, F. Porreca, M. Ossipov, 2006, Nature Neuroscience.

Opioid and melanocortin receptors: Do they have overlapping pharmacophores?

James P. Cain, V. Hruby, M. Cai, 2008, Biopolymers.

New potent biphalin analogues containing p-fluoro-l-phenylalanine at the 4,4′ positions and non-hydrazine linkers

V. Hruby, A. Mollica, A. Stefanucci, 2011, Amino Acids.

Synthesis of Stable and Potent δ/μ Opioid Peptides: Analogues of H-Tyr-c[d-Cys-Gly-Phe-d-Cys]-OH by Ring-Closing Metathesis

V. Hruby, A. Mollica, L. Mannina, 2007 .

Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists.

V. Hruby, E. Navratilova, H. Yamamura, 2009, Journal of medicinal chemistry.

Synthesis and evaluation of new endomorphin analogues modified at the Pro(2) residue.

V. Hruby, A. Mollica, D. Torino, 2009, Bioorganic & medicinal chemistry letters.

Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain.

R. Gillies, V. Hruby, F. Porreca, 2010, Bioorganic & medicinal chemistry letters.

Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors.

V. Hruby, F. Porreca, J. Lai, 2007, Journal of medicinal chemistry.

Design and Synthesis of Novel Hydrazide-Linked Bifunctional Peptides as δ/μ Opioid Receptor Agonists and CCK-1/CCK-2 Receptor Antagonists

V. Hruby, F. Porreca, J. Lai, 2006 .

Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at μ and δ opioid receptors

V. Hruby, F. Porreca, J. Lai, 2007 .

Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at mu and delta opioid receptors.

V. Hruby, F. Porreca, J. Lai, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity.

V. Hruby, F. Porreca, J. Lai, 2006, Bioorganic & medicinal chemistry letters.

Chiral Effect of a Phe Residue in Position 3 of the Dmt1-L(or D)-Tic2 Analogues on Opioid Functional Activities.

V. Hruby, F. Porreca, Hongchang Qu, 2013, ACS Medicinal Chemistry Letters.

Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activities.

V. Hruby, E. Navratilova, T. Vanderah, 2013, Bioorganic & medicinal chemistry letters.

Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.

V. Hruby, H. Yamamura, T. Vanderah, 2011, Journal of medicinal chemistry.

Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines.

V. Hruby, E. Navratilova, H. Yamamura, 2010, Journal of medicinal chemistry.

The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety.

V. Hruby, H. Yamamura, T. Vanderah, 2009, Bioorganic & medicinal chemistry.

Design, Synthesis, and Biological Evaluation of Novel Bifunctional C-Terminal-Modified Peptides for δ/μ Opioid Receptor Agonists and Neurokinin-1 Receptor Antagonists

V. Hruby, E. Navratilova, H. Yamamura, 2007 .

Effect of anchoring 4-anilidopiperidines to opioid peptides.

V. Hruby, T. Vanderah, F. Porreca, 2013, Bioorganic & medicinal chemistry letters.

Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain

Isuru R. Kumarasinghe, V. Hruby, T. Vanderah, 2011, Brain Research.

Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2.

V. Hruby, A. Mollica, A. Masi, 2010, European journal of medicinal chemistry.

Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-alpha,beta-didehydrophenylalanine (Delta(Z)Phe) residues.

V. Hruby, A. Mollica, D. Torino, 2010, Journal of medicinal chemistry.

Pharmacological characterization of the cloned kappa opioid receptor as a kappa1b subtype

R. Rothman, F. Porreca, J. Lai, 1994, Neuroreport.

‘Knock-down’ of spinal CB1 receptors produces abnormal pain and elevates spinal dynorphin content in mice

F. Porreca, M. Ossipov, J. Lai, 2002, Pain.

The cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues.

V. Hruby, A. Mollica, Cristina Campestre, 2012, Journal of medicinal chemistry.

The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.

V. Hruby, E. Navratilova, H. Yamamura, 2008, Journal of medicinal chemistry.

A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.

V. Hruby, E. Navratilova, H. Yamamura, 2008, Journal of medicinal chemistry.

Synthesis and biological activity of the first cyclic biphalin analogues.

V. Hruby, A. Mollica, F. Porreca, 2006, Bioorganic & medicinal chemistry letters.

Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors.

V. Hruby, F. Porreca, J. Lai, 2006, Journal of medicinal chemistry.

Design of novel peptide ligands which have opioid agonist activity and CCK antagonist activity for the treatment of pain.

V. Hruby, T. Vanderah, F. Porreca, 2003, Life sciences.

Synthesis of constrained analogues of cholecystokinin/opioid chimeric peptides.

James P. Cain, J. Ndungu, V. Hruby, 2006, Tetrahedron letters.

cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues: part 2.

V. Hruby, A. Mollica, L. Mannina, 2012, Journal of medicinal chemistry.

Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis.

V. Hruby, A. Mollica, L. Mannina, 2007, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists.

V. Hruby, E. Navratilova, H. Yamamura, 2007, Journal of medicinal chemistry.

Development of Novel Enkephalin Analogues that Have Enhanced Opioid Activities at Both μ and δ Opioid Receptors

V. Hruby, Chad K. Park, F. Porreca, 2007 .

Structure–activity relationships of bifunctional cyclic disulfide peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors

Jinfa Ying, V. Hruby, K. Kövér, 2008, Peptides.