Erik A. Lachapelle

发表

Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug–Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors

J. Pandit, K. Parris, Eric F. Johnson, 2015, Journal of medicinal chemistry.

Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation.

Claude Ambroise, D. Karanian, K. Bales, 2018, Journal of medicinal chemistry.

Discovery and Lead Optimization of Atropisomer D1 Agonists with Reduced Desensitization.

R. Kozak, David L. Gray, B. Rai, 2018, Journal of medicinal chemistry.

Design and optimization of selective azaindole amide M1 positive allosteric modulators.

Gregory W. Kauffman, R. Obach, J. Edgerton, 2016, Bioorganic & medicinal chemistry letters.

The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging.

R. J. Mather, L. Chen, K. Zasadny, 2017, Journal of medicinal chemistry.

Stereoselective synthesis of spiropiperidines as BACE-1 aspartyl protease inhibitors via late stage N-arylation of a 1,8-diazaspiro[4.5]dec-3-en-2-one pharmacophore.

S. Sakya, Kevin Ogilvie, Jason K. Dutra, 2013, The Journal of organic chemistry.

Fluorophosphonates on‐Demand: A General and Simplified Approach toward Fluorophosphonate Synthesis

Timothy L. Foley, Christopher W. am Ende, Zhen Huang, 2021, Chembiochem : a European journal of chemical biology.

Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK).

J. Pandit, J. Culp, K. Parris, 2017, Journal of medicinal chemistry.

Class I HDAC inhibition is a novel pathway for regulating astrocytic apoE secretion

J. Duerr, K. Bales, Fabien Vincent, 2018, PloS one.

Strategies toward optimization of the metabolism of a series of serotonin-4 partial agonists: investigation of azetidines as piperidine isosteres

Gregory W. Kauffman, R. Obach, M. Brodney, 2016, Xenobiotica; the fate of foreign compounds in biological systems.

The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging.

R. J. Mather, L. Chen, K. Zasadny, 2017, Journal of medicinal chemistry.

Discovery of Selective M4 Muscarinic Acetylcholine Receptor Agonists with Novel Carbamate Isosteres.

R. Kozak, Qingyi Yang, C. Butler, 2019, ACS medicinal chemistry letters.

Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M4 Muscarinic Acetylcholine Receptor.

Kevin Ogilvie, M. Brodney, S. Mente, 2024, Journal of medicinal chemistry.